skip to content
Phosphodiesterase inhibitors Preview this item
ClosePreview this item
Checking...

Phosphodiesterase inhibitors

Author: Christian Schudt; Gordon Dent; Klaus F Rabe
Publisher: San Diego : Academic Press, 1996.
Series: Handbook of immunopharmacology., Drugs.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Non-selective inhibitors of cyclic nucleotide phosphodiesterase (PDE), such as theophylline, have been used extensively since 1958. In the decade of the '70s, various PDE isoenzymes were defined which led to the development of the second generation of PDE inhibitors. Currently a variety of these new inhibitors are under test as potential anti-inflammatory drugs. During the past five years, molecular biology has  Read more...
Rating:

(not yet rated) 0 with reviews - Be the first.

Subjects
More like this

Find a copy in the library

&AllPage.SpinnerRetrieving; Finding libraries that hold this item...

Details

Genre/Form: Electronic books
Additional Physical Format: Print version:
Phosphodiesterase inhibitors.
San Diego : Academic Press, 1996
(OCoLC)35682108
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Christian Schudt; Gordon Dent; Klaus F Rabe
ISBN: 9780122107207 0122107209 9780080538815 0080538819 1281058971 9781281058973
OCLC Number: 162129160
Reproduction Notes: Electronic reproduction. [S.l.] : HathiTrust Digital Library, 2010. MiAaHDL
Description: 1 online resource (xvi, 228 pages, [2] pages of plates) : illustrations (some color).
Details: Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002.
Contents: K.M. Ferguson and K. Loughney, Identification and Quantification of PDE Isoenzymes and Subtypes by Molecular Biological Methods. --
H. Tenor and C. Schudt, Analysis of PDE Isoenzyme Profiles in Cells and Tissues by Pharmacological Methods. --
K.F. Rabe, Effects of Theophylline and Nonselective Xanthine Derivatives on PDE Isoenzymes and Cellular Function. --
R.K. Sharma, Interaction of PDE I Inhibitors with Isoenzymes and Cell Functions. --
R. Fischmeister, EHNA as an Inhibitor of PDE II. --
V.C. Manganiello, PDE II Inhibitors as Therapeutic Agents. --
M.A. Giembycz, Interaction of PDE IV Inhibitors with Enzymes and Cell Functions and their Therapeutic Potential. --
P.J. Silver, Inhibition of PDE Isoenzymes and Cell Function by Selective PDE V Inhibitors. --
J.D. Corbin, Design and Synthesis of Xanthines and Cyclic GMP Analogues as Potent Inhibitors of PDE V and PDE I. --
A. Hatzelmann, Enzymatic and Functional Inhibition of Dual-Selective Inhibitors. --
R. Alvarez, Subtype Selectivity, Inhibition of Cell Function and Therapeutic Potential of RS 25344. --
J.E. Souness, Characterization of Different States of PDE IV by Rolipram and RP 73401. --
T.J. Torphy, Functional Significance of Two Sites for Inhibitors at PDE IV. --
Subject Index. Identification and quantification of PDE isoenzymes and subtypes by molecular biological methods --
Analysis of PDE isoenzyme profiles in cells and tissues by pharmacological methods --
Effects of theophylline and non-selective xanthine derivatives on PDE isoenzymes nad cellular function --
Ca2+/calmodulin-dependent cyclic nucleotide phosphodiesterase (PDEI) --
EHNA as an inhibitor of PDE2; a pharmacological and biochemical study in cardiac myocytes --
cGMP-inhibited phosphodiesterases (PDE3) --
Interaction of PDE4 inhibitors with enzymes and cell functions --
Inhibition of phosphodiesterase isoenzymes and cell function by selective PDE5 inhibitors --
Design and synthesis of xanthines and cyclic GMP analogues as potent inhibitors of PDE5 --
Enzymatic and functional aspects of dual-selective PDE3/4 inhibitors --
An isoform-selective inhibitor of cyclic AMP-specific phosphodiesterase (PDE4) with anti-inflammatory properties --
Characterization of different states of PDE4 by rolipram and RP 73041 --
Molecular aspects of inhibitor interaction with PDE4.
Series Title: Handbook of immunopharmacology., Drugs.
Responsibility: edited by Christian Schudt, Gordon Dent and Klaus F. Rabe.

Abstract:

Non-selective inhibitors of cyclic nucleotide phosphodiesterase (PDE), such as theophylline, have been in use since 1958. A variety of these inhibitors are under test as potential anti-inflammatory  Read more...

Reviews

User-contributed reviews
Retrieving GoodReads reviews...
Retrieving DOGObooks reviews...

Tags

Be the first.
Confirm this request

You may have already requested this item. Please select Ok if you would like to proceed with this request anyway.

Linked Data


Primary Entity

<http://www.worldcat.org/oclc/162129160> # Phosphodiesterase inhibitors
    a schema:Book, schema:MediaObject, schema:CreativeWork ;
    library:oclcnum "162129160" ;
    library:placeOfPublication <http://experiment.worldcat.org/entity/work/data/909304404#Place/san_diego> ; # San Diego
    library:placeOfPublication <http://id.loc.gov/vocabulary/countries/cau> ;
    schema:about <http://dewey.info/class/612.01513/e22/> ;
    schema:about <http://experiment.worldcat.org/entity/work/data/909304404#Topic/phosphodiesterases_inhibitors_therapeutic_use> ; # Phosphodiesterases--Inhibitors--Therapeutic use
    schema:about <http://experiment.worldcat.org/entity/work/data/909304404#Topic/phosphodiesterasen> ; # Phosphodiesterasen
    schema:about <http://experiment.worldcat.org/entity/work/data/909304404#Topic/medical_pharmacology> ; # MEDICAL--Pharmacology
    schema:about <http://experiment.worldcat.org/entity/work/data/909304404#Topic/phosphodiesterase_inhibitors_therapeutic_use> ; # Phosphodiesterase Inhibitors--therapeutic use
    schema:about <http://experiment.worldcat.org/entity/work/data/909304404#Topic/aufsatzsammlung> ; # Aufsatzsammlung
    schema:about <http://experiment.worldcat.org/entity/work/data/909304404#Topic/phosphodiesterase_inhibitors_pharmacology> ; # Phosphodiesterase Inhibitors--pharmacology
    schema:about <http://experiment.worldcat.org/entity/work/data/909304404#Topic/medical_biochemistry> ; # MEDICAL--Biochemistry
    schema:about <http://experiment.worldcat.org/entity/work/data/909304404#Topic/phosphodiesterases_inhibitors> ; # Phosphodiesterases--Inhibitors
    schema:about <http://experiment.worldcat.org/entity/work/data/909304404#Topic/immunpharmakologie> ; # Immunpharmakologie
    schema:about <http://experiment.worldcat.org/entity/work/data/909304404#Topic/inhibitor> ; # Inhibitor
    schema:bookFormat schema:EBook ;
    schema:contributor <http://viaf.org/viaf/120509369> ; # Gordon Dent
    schema:contributor <http://viaf.org/viaf/120509353> ; # Christian Schudt
    schema:contributor <http://viaf.org/viaf/120509382> ; # Klaus F. Rabe
    schema:datePublished "1996" ;
    schema:description "K.M. Ferguson and K. Loughney, Identification and Quantification of PDE Isoenzymes and Subtypes by Molecular Biological Methods. -- H. Tenor and C. Schudt, Analysis of PDE Isoenzyme Profiles in Cells and Tissues by Pharmacological Methods. -- K.F. Rabe, Effects of Theophylline and Nonselective Xanthine Derivatives on PDE Isoenzymes and Cellular Function. -- R.K. Sharma, Interaction of PDE I Inhibitors with Isoenzymes and Cell Functions. -- R. Fischmeister, EHNA as an Inhibitor of PDE II. -- V.C. Manganiello, PDE II Inhibitors as Therapeutic Agents. -- M.A. Giembycz, Interaction of PDE IV Inhibitors with Enzymes and Cell Functions and their Therapeutic Potential. -- P.J. Silver, Inhibition of PDE Isoenzymes and Cell Function by Selective PDE V Inhibitors. -- J.D. Corbin, Design and Synthesis of Xanthines and Cyclic GMP Analogues as Potent Inhibitors of PDE V and PDE I. -- A. Hatzelmann, Enzymatic and Functional Inhibition of Dual-Selective Inhibitors. -- R. Alvarez, Subtype Selectivity, Inhibition of Cell Function and Therapeutic Potential of RS 25344. -- J.E. Souness, Characterization of Different States of PDE IV by Rolipram and RP 73401. -- T.J. Torphy, Functional Significance of Two Sites for Inhibitors at PDE IV. -- Subject Index."@en ;
    schema:description "Identification and quantification of PDE isoenzymes and subtypes by molecular biological methods -- Analysis of PDE isoenzyme profiles in cells and tissues by pharmacological methods -- Effects of theophylline and non-selective xanthine derivatives on PDE isoenzymes nad cellular function -- Ca2+/calmodulin-dependent cyclic nucleotide phosphodiesterase (PDEI) -- EHNA as an inhibitor of PDE2; a pharmacological and biochemical study in cardiac myocytes -- cGMP-inhibited phosphodiesterases (PDE3) -- Interaction of PDE4 inhibitors with enzymes and cell functions -- Inhibition of phosphodiesterase isoenzymes and cell function by selective PDE5 inhibitors -- Design and synthesis of xanthines and cyclic GMP analogues as potent inhibitors of PDE5 -- Enzymatic and functional aspects of dual-selective PDE3/4 inhibitors -- An isoform-selective inhibitor of cyclic AMP-specific phosphodiesterase (PDE4) with anti-inflammatory properties -- Characterization of different states of PDE4 by rolipram and RP 73041 -- Molecular aspects of inhibitor interaction with PDE4."@en ;
    schema:description "Non-selective inhibitors of cyclic nucleotide phosphodiesterase (PDE), such as theophylline, have been used extensively since 1958. In the decade of the '70s, various PDE isoenzymes were defined which led to the development of the second generation of PDE inhibitors. Currently a variety of these new inhibitors are under test as potential anti-inflammatory drugs. During the past five years, molecular biology has revealed a superfamily of these phosphodiesterase isoenzymes. This book summarizes the present state of knowledge, as well as giving a comprehensive description of the compounds available. It will be invaluable for everyone who wants to choose the most suitable PDE inhibitor for their research or who is dealing with such drugs in a clinical setting. Key Features * Utilizes actual testing and research of new PDE inhibitors * Valuable for researchers and students alike."@en ;
    schema:exampleOfWork <http://worldcat.org/entity/work/id/909304404> ;
    schema:genre "Electronic books"@en ;
    schema:inLanguage "en" ;
    schema:isPartOf <http://experiment.worldcat.org/entity/work/data/909304404#Series/handbook_of_immunopharmacology> ; # Handbook of immunopharmacology.
    schema:isPartOf <http://experiment.worldcat.org/entity/work/data/909304404#Series/the_handbook_of_immunopharmacology_drugs> ; # The Handbook of immunopharmacology. Drugs
    schema:isSimilarTo <http://www.worldcat.org/oclc/35682108> ;
    schema:name "Phosphodiesterase inhibitors"@en ;
    schema:productID "162129160" ;
    schema:publication <http://www.worldcat.org/title/-/oclc/162129160#PublicationEvent/san_diego_academic_press_1996> ;
    schema:publisher <http://experiment.worldcat.org/entity/work/data/909304404#Agent/academic_press> ; # Academic Press
    schema:url <http://www.sciencedirect.com/science/book/9780122107207> ;
    schema:url <http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=210369> ;
    schema:url <http://catalog.hathitrust.org/api/volumes/oclc/35682108.html> ;
    schema:url <http://public.ebookcentral.proquest.com/choice/publicfullrecord.aspx?p=318135> ;
    schema:url <http://site.ebrary.com/id/10203646> ;
    schema:url <http://www.myilibrary.com?id=105897> ;
    schema:url <http://dproxy.library.dc-uoit.ca/login?url=https://www.sciencedirect.com/science/book/9780122107207> ;
    schema:url <http://www.myilibrary.com?id=105897&ref=toc> ;
    schema:workExample <http://worldcat.org/isbn/9781281058973> ;
    schema:workExample <http://worldcat.org/isbn/9780080538815> ;
    schema:workExample <http://worldcat.org/isbn/9780122107207> ;
    wdrs:describedby <http://www.worldcat.org/title/-/oclc/162129160> ;
    .


Related Entities

<http://experiment.worldcat.org/entity/work/data/909304404#Agent/academic_press> # Academic Press
    a bgn:Agent ;
    schema:name "Academic Press" ;
    .

<http://experiment.worldcat.org/entity/work/data/909304404#Series/handbook_of_immunopharmacology> # Handbook of immunopharmacology.
    a bgn:PublicationSeries ;
    schema:hasPart <http://www.worldcat.org/oclc/162129160> ; # Phosphodiesterase inhibitors
    schema:name "Handbook of immunopharmacology." ;
    .

<http://experiment.worldcat.org/entity/work/data/909304404#Series/the_handbook_of_immunopharmacology_drugs> # The Handbook of immunopharmacology. Drugs
    a bgn:PublicationSeries ;
    schema:hasPart <http://www.worldcat.org/oclc/162129160> ; # Phosphodiesterase inhibitors
    schema:name "The Handbook of immunopharmacology. Drugs" ;
    .

<http://experiment.worldcat.org/entity/work/data/909304404#Topic/immunpharmakologie> # Immunpharmakologie
    a schema:Intangible ;
    schema:name "Immunpharmakologie"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/909304404#Topic/medical_biochemistry> # MEDICAL--Biochemistry
    a schema:Intangible ;
    schema:name "MEDICAL--Biochemistry"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/909304404#Topic/medical_pharmacology> # MEDICAL--Pharmacology
    a schema:Intangible ;
    schema:name "MEDICAL--Pharmacology"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/909304404#Topic/phosphodiesterase_inhibitors_pharmacology> # Phosphodiesterase Inhibitors--pharmacology
    a schema:Intangible ;
    schema:name "Phosphodiesterase Inhibitors--pharmacology"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/909304404#Topic/phosphodiesterase_inhibitors_therapeutic_use> # Phosphodiesterase Inhibitors--therapeutic use
    a schema:Intangible ;
    schema:name "Phosphodiesterase Inhibitors--therapeutic use"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/909304404#Topic/phosphodiesterasen> # Phosphodiesterasen
    a schema:Intangible ;
    schema:name "Phosphodiesterasen"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/909304404#Topic/phosphodiesterases_inhibitors_therapeutic_use> # Phosphodiesterases--Inhibitors--Therapeutic use
    a schema:Intangible ;
    schema:hasPart <http://id.loc.gov/authorities/subjects/sh90000407> ;
    schema:name "Phosphodiesterases--Inhibitors--Therapeutic use"@en ;
    .

<http://viaf.org/viaf/120509353> # Christian Schudt
    a schema:Person ;
    schema:familyName "Schudt" ;
    schema:givenName "Christian" ;
    schema:name "Christian Schudt" ;
    .

<http://viaf.org/viaf/120509369> # Gordon Dent
    a schema:Person ;
    schema:familyName "Dent" ;
    schema:givenName "Gordon" ;
    schema:name "Gordon Dent" ;
    .

<http://viaf.org/viaf/120509382> # Klaus F. Rabe
    a schema:Person ;
    schema:familyName "Rabe" ;
    schema:givenName "Klaus F." ;
    schema:name "Klaus F. Rabe" ;
    .

<http://worldcat.org/isbn/9780080538815>
    a schema:ProductModel ;
    schema:isbn "0080538819" ;
    schema:isbn "9780080538815" ;
    .

<http://worldcat.org/isbn/9780122107207>
    a schema:ProductModel ;
    schema:isbn "0122107209" ;
    schema:isbn "9780122107207" ;
    .

<http://worldcat.org/isbn/9781281058973>
    a schema:ProductModel ;
    schema:isbn "1281058971" ;
    schema:isbn "9781281058973" ;
    .

<http://www.worldcat.org/oclc/35682108>
    a schema:CreativeWork ;
    rdfs:label "Phosphodiesterase inhibitors." ;
    schema:description "Print version:" ;
    schema:isSimilarTo <http://www.worldcat.org/oclc/162129160> ; # Phosphodiesterase inhibitors
    .


Content-negotiable representations

Close Window

Please sign in to WorldCat 

Don't have an account? You can easily create a free account.