skip to content
Phosphodiesterases : CNS functions and diseases Preview this item
ClosePreview this item
Checking...

Phosphodiesterases : CNS functions and diseases

Author: Han-Ting Zhang; Ying Xu; James M O'Donnell
Publisher: Cham : Springer, 2017.
Series: Advances in neurobiology, v. 17.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
PDEs are a family of enzymes that catalyze the hydrolysis of intracellular cyclic neucleotides. They are implicated in a number of disorders and dysfunctions and PDE inhibitors have already proven to be effective therapies for erectile dysfunction, COPD, and psoriatic arthiritis. This family of enzymes also plays a role in diseases and disorders of the CNS such as depression, anxiety, schizophrenia, and Alzheimer's  Read more...
Rating:

(not yet rated) 0 with reviews - Be the first.

Subjects
More like this

Find a copy in the library

&AllPage.SpinnerRetrieving; Finding libraries that hold this item...

Details

Genre/Form: Electronic books
Additional Physical Format: Printed edition:
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Han-Ting Zhang; Ying Xu; James M O'Donnell
ISBN: 9783319588117 3319588117
OCLC Number: 1005191724
Description: 1 online resource.
Contents: Part I. PDEs and Signaling, Circuitry, and Implications of CNS Functions and Disorders --
1. Phosphodiesterase Diversity and Signal Processing within cAMP Signaling Networks --
2. Current Understanding of PDE10A in the Modulation of Basal Ganglia Circuitry --
3. Interaction of Cdk5 and cAMP/PKA Signaling in the Mediation of Neuropsychiatric and Neurodegenerative Diseases --
4. The PDE4 cAMP-specific Phosphodiesterases: Targets for Drugs with Antidepressant and Memory-enhancing Action --
5. Phosphodiesterase-4B as a Therapeutic Target for Cognitive Impairment and Obesity-related Metabolic Diseases --
Part II. PDEs in Cognition of Aging and Alzheimer's Disease --
6. From age-related Cognitive Decline to Alzheimer's Disease: A Translational Overview of the Potential role for Phosphodiesterases --
7. The Past, Present, and Future of Phosphodiesterase-4 Modulation for age-induced Memory Loss --
8. A Role for Phosphodiesterase 11A (PDE11A) in the Formation of Social Memories and the Stabilization of Mood --
9. Role of PDE9 in Cognition --
Part III. PDEs in Parkinson's and Huntington's Diseases --
10. Regulation of Striatal Neuron Activity by Cyclic Nucleotide Signaling and Phosphodiesterase Inhibition: Implications for the Treatment of Parkinson's Disease --
11. Role of Phosphodiesterases in Huntington's Disease --
Part IV. PDEs and Psychiatric Disorders --
12. The role of Phosphodiesterase-2 in Psychiatric and Neurodegenerative Disorders --
13. Phosphodiesterase 1: A Unique Drug Target for Degenerative Diseases and Cognitive Dysfunction --
14. PDE Inhibitors for the Treatment of Schizophrenia --
Part V. PDEs and Others --
15. Targeting Phosphodiesterases in Pharmacotherapy for Substance Dependence --
16. Genetic Understanding of Stroke Treatment: Potential role for Phosphodiesterase Inhibitors --
17. A unique sub-pocket for Improvement of Selectivity of Phosphodiesterase Inhibitors in CNS.
Series Title: Advances in neurobiology, v. 17.
Responsibility: Han-Ting Zhang, Ying Xu, James M. O'Donnell, editors.

Abstract:

PDEs are a family of enzymes that catalyze the hydrolysis of intracellular cyclic neucleotides. They are implicated in a number of disorders and dysfunctions and PDE inhibitors have already proven to be effective therapies for erectile dysfunction, COPD, and psoriatic arthiritis. This family of enzymes also plays a role in diseases and disorders of the CNS such as depression, anxiety, schizophrenia, and Alzheimer's Disease. Unfortunately no effective PDE inhibitors have been developed for the treatment of these diseases. The proposed book will be a comprehensive overview of the current state of basic and translational research on PDE inhibitors written by internationally recognized experts. Authors will also discuss potential PDE subtypes and splice variants in the hopes that this will spur more creative approaches to PDE targeting drugs.

Reviews

User-contributed reviews
Retrieving GoodReads reviews...
Retrieving DOGObooks reviews...

Tags

Be the first.
Confirm this request

You may have already requested this item. Please select Ok if you would like to proceed with this request anyway.

Linked Data


Primary Entity

<http://www.worldcat.org/oclc/1005191724> # Phosphodiesterases : CNS functions and diseases
    a schema:CreativeWork, schema:MediaObject, schema:Book ;
    library:oclcnum "1005191724" ;
    library:placeOfPublication <http://experiment.worldcat.org/entity/work/data/4565161189#Place/cham> ; # Cham
    library:placeOfPublication <http://id.loc.gov/vocabulary/countries/sz> ;
    schema:about <http://experiment.worldcat.org/entity/work/data/4565161189#Topic/nervous_system_diseases_molecular_aspects> ; # Nervous system--Diseases--Molecular aspects
    schema:about <http://experiment.worldcat.org/entity/work/data/4565161189#Topic/phosphoric_diester_hydrolases> ; # Phosphoric Diester Hydrolases
    schema:about <http://dewey.info/class/572.7553/e23/> ;
    schema:about <http://experiment.worldcat.org/entity/work/data/4565161189#Topic/biomedicine> ; # Biomedicine
    schema:about <http://experiment.worldcat.org/entity/work/data/4565161189#Topic/phosphodiesterases> ; # Phosphodiesterases
    schema:about <http://experiment.worldcat.org/entity/work/data/4565161189#Topic/science_life_sciences_biochemistry> ; # SCIENCE--Life Sciences--Biochemistry
    schema:about <http://experiment.worldcat.org/entity/work/data/4565161189#Topic/neurosciences> ; # Neurosciences
    schema:bookFormat schema:EBook ;
    schema:contributor <http://experiment.worldcat.org/entity/work/data/4565161189#Person/zhang_han_ting> ; # Han-Ting Zhang
    schema:contributor <http://experiment.worldcat.org/entity/work/data/4565161189#Person/xu_ying> ; # Ying Xu
    schema:contributor <http://experiment.worldcat.org/entity/work/data/4565161189#Person/o_donnell_james_m> ; # James M. O'Donnell
    schema:datePublished "2017" ;
    schema:description "Part I. PDEs and Signaling, Circuitry, and Implications of CNS Functions and Disorders -- 1. Phosphodiesterase Diversity and Signal Processing within cAMP Signaling Networks -- 2. Current Understanding of PDE10A in the Modulation of Basal Ganglia Circuitry -- 3. Interaction of Cdk5 and cAMP/PKA Signaling in the Mediation of Neuropsychiatric and Neurodegenerative Diseases -- 4. The PDE4 cAMP-specific Phosphodiesterases: Targets for Drugs with Antidepressant and Memory-enhancing Action -- 5. Phosphodiesterase-4B as a Therapeutic Target for Cognitive Impairment and Obesity-related Metabolic Diseases -- Part II. PDEs in Cognition of Aging and Alzheimer's Disease -- 6. From age-related Cognitive Decline to Alzheimer's Disease: A Translational Overview of the Potential role for Phosphodiesterases -- 7. The Past, Present, and Future of Phosphodiesterase-4 Modulation for age-induced Memory Loss -- 8. A Role for Phosphodiesterase 11A (PDE11A) in the Formation of Social Memories and the Stabilization of Mood -- 9. Role of PDE9 in Cognition -- Part III. PDEs in Parkinson's and Huntington's Diseases -- 10. Regulation of Striatal Neuron Activity by Cyclic Nucleotide Signaling and Phosphodiesterase Inhibition: Implications for the Treatment of Parkinson's Disease -- 11. Role of Phosphodiesterases in Huntington's Disease -- Part IV. PDEs and Psychiatric Disorders -- 12. The role of Phosphodiesterase-2 in Psychiatric and Neurodegenerative Disorders -- 13. Phosphodiesterase 1: A Unique Drug Target for Degenerative Diseases and Cognitive Dysfunction -- 14. PDE Inhibitors for the Treatment of Schizophrenia -- Part V. PDEs and Others -- 15. Targeting Phosphodiesterases in Pharmacotherapy for Substance Dependence -- 16. Genetic Understanding of Stroke Treatment: Potential role for Phosphodiesterase Inhibitors -- 17. A unique sub-pocket for Improvement of Selectivity of Phosphodiesterase Inhibitors in CNS."@en ;
    schema:description "PDEs are a family of enzymes that catalyze the hydrolysis of intracellular cyclic neucleotides. They are implicated in a number of disorders and dysfunctions and PDE inhibitors have already proven to be effective therapies for erectile dysfunction, COPD, and psoriatic arthiritis. This family of enzymes also plays a role in diseases and disorders of the CNS such as depression, anxiety, schizophrenia, and Alzheimer's Disease. Unfortunately no effective PDE inhibitors have been developed for the treatment of these diseases. The proposed book will be a comprehensive overview of the current state of basic and translational research on PDE inhibitors written by internationally recognized experts. Authors will also discuss potential PDE subtypes and splice variants in the hopes that this will spur more creative approaches to PDE targeting drugs."@en ;
    schema:exampleOfWork <http://worldcat.org/entity/work/id/4565161189> ;
    schema:genre "Electronic books"@en ;
    schema:inLanguage "en" ;
    schema:isPartOf <http://experiment.worldcat.org/entity/work/data/4565161189#Series/advances_in_neurobiology> ; # Advances in neurobiology ;
    schema:isSimilarTo <http://worldcat.org/entity/work/data/4565161189#CreativeWork/> ;
    schema:name "Phosphodiesterases : CNS functions and diseases"@en ;
    schema:productID "1005191724" ;
    schema:publication <http://www.worldcat.org/title/-/oclc/1005191724#PublicationEvent/cham_springer_2017> ;
    schema:publisher <http://experiment.worldcat.org/entity/work/data/4565161189#Agent/springer> ; # Springer
    schema:url <http://www.vlebooks.com/vleweb/product/openreader?id=none&isbn=9783319588117> ;
    schema:url <http://link.springer.com/10.1007/978-3-319-58811-7> ;
    schema:url <https://link.springer.com/openurl?genre=book&isbn=978-3-319-58809-4> ;
    schema:url <http://rave.ohiolink.edu/ebooks/ebc/9783319588117> ;
    schema:url <https://0-link-springer-com.pugwash.lib.warwick.ac.uk/10.1007/978-3-319-58811-7> ;
    schema:url <http://VH7QX3XE2P.search.serialssolutions.com/?V=1.0&L=VH7QX3XE2P&S=JCs&C=TC0001875621&T=marc&tab=BOOKS> ;
    schema:url <http://public.eblib.com/choice/publicfullrecord.aspx?p=5061480> ;
    schema:url <https://link.springer.com/10.1007/978-3-319-58811-7> ;
    schema:url <http://link.springer.com/book/10.1007/978-3-319-58811-7> ;
    schema:url <http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=1608181> ;
    schema:url <https://0-link-springer-com.pugwash.lib.warwick.ac.uk/book/10.1007/978-3-319-58811-7> ;
    schema:url <http://public.ebookcentral.proquest.com/choice/publicfullrecord.aspx?p=5061480> ;
    schema:url <http://dx.doi.org/10.1007/978-3-319-58811-7> ;
    schema:workExample <http://worldcat.org/isbn/9783319588117> ;
    schema:workExample <http://dx.doi.org/10.1007/978-3-319-58811-7> ;
    umbel:isLike <http://bnb.data.bl.uk/id/resource/GBB972833> ;
    wdrs:describedby <http://www.worldcat.org/title/-/oclc/1005191724> ;
    .


Related Entities

<http://experiment.worldcat.org/entity/work/data/4565161189#Person/o_donnell_james_m> # James M. O'Donnell
    a schema:Person ;
    schema:familyName "O'Donnell" ;
    schema:givenName "James M." ;
    schema:name "James M. O'Donnell" ;
    .

<http://experiment.worldcat.org/entity/work/data/4565161189#Person/zhang_han_ting> # Han-Ting Zhang
    a schema:Person ;
    schema:familyName "Zhang" ;
    schema:givenName "Han-Ting" ;
    schema:name "Han-Ting Zhang" ;
    .

<http://experiment.worldcat.org/entity/work/data/4565161189#Series/advances_in_neurobiology> # Advances in neurobiology ;
    a bgn:PublicationSeries ;
    schema:hasPart <http://www.worldcat.org/oclc/1005191724> ; # Phosphodiesterases : CNS functions and diseases
    schema:name "Advances in neurobiology ;" ;
    schema:name "Advances in Neurobiology ;" ;
    .

<http://experiment.worldcat.org/entity/work/data/4565161189#Topic/nervous_system_diseases_molecular_aspects> # Nervous system--Diseases--Molecular aspects
    a schema:Intangible ;
    schema:name "Nervous system--Diseases--Molecular aspects"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/4565161189#Topic/phosphodiesterases> # Phosphodiesterases
    a schema:Intangible ;
    schema:name "Phosphodiesterases"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/4565161189#Topic/phosphoric_diester_hydrolases> # Phosphoric Diester Hydrolases
    a schema:Intangible ;
    schema:name "Phosphoric Diester Hydrolases"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/4565161189#Topic/science_life_sciences_biochemistry> # SCIENCE--Life Sciences--Biochemistry
    a schema:Intangible ;
    schema:name "SCIENCE--Life Sciences--Biochemistry"@en ;
    .

<http://worldcat.org/entity/work/data/4565161189#CreativeWork/>
    a schema:CreativeWork ;
    schema:description "Printed edition:" ;
    schema:isSimilarTo <http://www.worldcat.org/oclc/1005191724> ; # Phosphodiesterases : CNS functions and diseases
    .

<http://worldcat.org/isbn/9783319588117>
    a schema:ProductModel ;
    schema:isbn "3319588117" ;
    schema:isbn "9783319588117" ;
    .


Content-negotiable representations

Close Window

Please sign in to WorldCat 

Don't have an account? You can easily create a free account.