Population-based screening for colorectal cancer (Book, 2010) [WorldCat.org]
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Population-based screening for colorectal cancer

Author: Lieke Hol
Publisher: Erasmus University Rotterdam 2010-04-16
Edition/Format: Book Book : English
Summary:
textabstractThe incidence of colorectal cancer (CRC) shows considerable geographical differences aroundthe world. The highest incidence rates are mainly seen in the Western world including NorthAmerica, Australia/New Zealand, Western Europe, and Japan. Development countries reportthe lowest incidence rates. In Europe, CRC is the second most common diagnosed cancer inwomen and third in men (13% of all cancer cases in  Read more...
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Details

Document Type: Book
All Authors / Contributors: Lieke Hol
ISBN: 978-90-8559-950-0
Language Note: English
Unique Identifier: 6892891628
Awards:

Abstract:

textabstractThe incidence of colorectal cancer (CRC) shows considerable geographical differences aroundthe world. The highest incidence rates are mainly seen in the Western world including NorthAmerica, Australia/New Zealand, Western Europe, and Japan. Development countries reportthe lowest incidence rates. In Europe, CRC is the second most common diagnosed cancer inwomen and third in men (13% of all cancer cases in both women and men). Incidence ratesare somewhat higher in men (1.2:1.0). The lifetime incidence of CRC in patients at average riskis approximately five percent. Incidence rates show demographic disparities over the lastdecades, with a gradual increase in South/Eastern Europe, stabilising numbers in North andWest Europe, and a declining trend in the United States. Age is a major risk factor for thedevelopment of CRC. CRC rarely develops before the age of 40 (IKC), except in patients with agenetic predisposition. Incidence rates rapidly increase beyond the age of 50.In Europe, CRC ranked second (12% of all cancer related mortality) in terms of cancer relatedmortality 1, despite the significant increase in five-year survival in the last two decades. Thisimprovement was in particular due to resection of rectal cancer with sharp dissection of themesorectum en bloc with the rectum (total mesorectal excision) combined with pre-operativeradiotherapy, and usage of new chemotherapeutic agents in various combinations. Additionally,improvement in outcome can be attributed to detection of the disease at an earlierstage due to screening and surveillance programmes.

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