skip to content
Population genetic history and patterns of admixture Examples from northeastern and southern Africa. Preview this item
ClosePreview this item
Checking...

Population genetic history and patterns of admixture Examples from northeastern and southern Africa.

Author: Nina Hollfelder; Mattias Jakobsson; Michele Ramsay; Uppsala universitet Teknisk-naturvetenskapliga vetenskapsområdet.
Publisher: Uppsala Acta Universitatis Upsaliensis 2018.
Dissertation: Diss. (sammanfattning) Uppsala : Uppsala universitet, 2018.
Series: Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology.
Edition/Format:   Thesis/dissertation : Document : Thesis/dissertation : eBook   Computer File : EnglishView all editions and formats
Summary:
The origin of humans lies in Africa, as has been shown by archaeology, paleontology and genetics. Here, we can find the largest genetic diversity and the deepest split among human populations. African genetic diversity has been shaped by a long and complex history. In this thesis, I applied population genomic methods to investigate different aspects of the demographic history of Africa, specifically northeast and  Read more...
Rating:

(not yet rated) 0 with reviews - Be the first.

Subjects
More like this

Find a copy online

Links to this item

Find a copy in the library

&AllPage.SpinnerRetrieving; Finding libraries that hold this item...

Details

Additional Physical Format: Annat format
Material Type: Document, Thesis/dissertation, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Nina Hollfelder; Mattias Jakobsson; Michele Ramsay; Uppsala universitet Teknisk-naturvetenskapliga vetenskapsområdet.
OCLC Number: 1027085967
Notes: Härtill 4 uppsatser.
Doctor philosophiae.
Docteur èn technologie.
teknologie doktorsexamen.
degree of Doctor of Philosophy.
Description: 1 online resource (57)
Series Title: Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology.

Abstract:

The origin of humans lies in Africa, as has been shown by archaeology, paleontology and genetics. Here, we can find the largest genetic diversity and the deepest split among human populations. African genetic diversity has been shaped by a long and complex history. In this thesis, I applied population genomic methods to investigate different aspects of the demographic history of Africa, specifically northeast and southern Africa. Both of these regions are population melting-pots, with many historically known major migrations. In northeast African populations, Eurasian admixture in central, northern, and eastern Sudanese populations was identified to be of Middle Eastern origin and the admixture time coincides with the Arab expansion. In northeast Africa I also studied alleles associated with lactase persistence, the ability to digest milk at an adult age. A wide diversity of these alleles was detected in Sudan, most commonly among pastoralists. The presence of a Middle Eastern LP-allele and absence of a European LP-allele is consistent with the admixture pattern observed in the first paper. I deciphered the patterns of genetic admixture in the Afrikaner population of South Africa and compared admixture patterns of the X-chromosome and autosomes to disentangle sex-biased admixture in southern African populations. The Afrikaner were shown to carry on average 5% non-European admixture, mostly from Khoe-San, East and South Asian sources. The admixture was sex-biased, with larger contributions from European males and admixture with Africans can be dated to 9-10 generations ago – fitting previous genealogical estimates of the age and the history of the population. Bantu-speaker/Khoe-San contact shows a pattern of female Bantu-speaker bias, which is conflicting with previous mtDNA and Y-chromosome studies. A change in mate-choice over time could explain this discrepancy. This thesis contributes to a deeper understanding of African demographic history in general and of some previously understudied populations and geographic areas in particular.

Reviews

User-contributed reviews
Retrieving GoodReads reviews...
Retrieving DOGObooks reviews...

Tags

Be the first.
Confirm this request

You may have already requested this item. Please select Ok if you would like to proceed with this request anyway.

Linked Data


Primary Entity

<http://www.worldcat.org/oclc/1027085967> # Population genetic history and patterns of admixture Examples from northeastern and southern Africa.
    a bgn:Thesis, schema:CreativeWork, schema:MediaObject, schema:Book ;
   bgn:inSupportOf "Diss. (sammanfattning) Uppsala : Uppsala universitet, 2018." ;
   library:oclcnum "1027085967" ;
   library:placeOfPublication <http://experiment.worldcat.org/entity/work/data/4837148870#Place/uppsala> ; # Uppsala
   library:placeOfPublication <http://id.loc.gov/vocabulary/countries/sw> ;
   schema:about <http://experiment.worldcat.org/entity/work/data/4837148870#Thing/population_structure> ; # population structure
   schema:about <http://experiment.worldcat.org/entity/work/data/4837148870#Topic/genetik> ; # Genetik
   schema:about <http://experiment.worldcat.org/entity/work/data/4837148870#Topic/evolutionsbiologi> ; # Evolutionsbiologi
   schema:about <http://experiment.worldcat.org/entity/work/data/4837148870#Thing/genetic_admixture> ; # genetic admixture
   schema:about <http://experiment.worldcat.org/entity/work/data/4837148870#Topic/biological_sciences> ; # Biological Sciences
   schema:about <http://experiment.worldcat.org/entity/work/data/4837148870#Topic/biology_with_specialization_in_evolutionary_organismal_biology> ; # Biology with specialization in Evolutionary Organismal Biology
   schema:about <http://experiment.worldcat.org/entity/work/data/4837148870#Topic/biologi_med_inriktning_mot_evolutionar_organismbiologi> ; # Biologi med inriktning mot evolutionär organismbiologi
   schema:about <http://experiment.worldcat.org/entity/work/data/4837148870#Topic/natural_sciences> ; # Natural Sciences
   schema:about <http://experiment.worldcat.org/entity/work/data/4837148870#Thing/lactase_persistence> ; # lactase persistence
   schema:about <http://experiment.worldcat.org/entity/work/data/4837148870#Topic/bioinformatics_computational_biology> ; # Bioinformatics (Computational Biology)
   schema:about <http://experiment.worldcat.org/entity/work/data/4837148870#Topic/data_och_informationsvetenskap> ; # Data- och informationsvetenskap
   schema:about <http://experiment.worldcat.org/entity/work/data/4837148870#Topic/bioinformatik_berakningsbiologi> ; # Bioinformatik (beräkningsbiologi)
   schema:about <http://experiment.worldcat.org/entity/work/data/4837148870#Topic/naturvetenskap> ; # Naturvetenskap
   schema:about <http://experiment.worldcat.org/entity/work/data/4837148870#Topic/biologiska_vetenskaper> ; # Biologiska vetenskaper
   schema:about <http://experiment.worldcat.org/entity/work/data/4837148870#Thing/africa> ; # Africa
   schema:about <http://experiment.worldcat.org/entity/work/data/4837148870#Topic/evolutionary_biology> ; # Evolutionary Biology
   schema:about <http://experiment.worldcat.org/entity/work/data/4837148870#Thing/sex_biased_admixture> ; # sex-biased admixture
   schema:about <http://experiment.worldcat.org/entity/work/data/4837148870#Topic/genetics> ; # Genetics
   schema:about <http://experiment.worldcat.org/entity/work/data/4837148870#Topic/computer_and_information_science> ; # Computer and Information Science
   schema:about <http://experiment.worldcat.org/entity/work/data/4837148870#Thing/genomic_variation> ; # genomic variation
   schema:about <http://experiment.worldcat.org/entity/work/data/4837148870#Thing/population_genomics> ; # population genomics
   schema:about <http://experiment.worldcat.org/entity/work/data/4837148870#Thing/human_evolutionary_genetics> ; # human evolutionary genetics
   schema:author <http://experiment.worldcat.org/entity/work/data/4837148870#Person/hollfelder_nina_1985> ; # Nina Hollfelder
   schema:contributor <http://experiment.worldcat.org/entity/work/data/4837148870#Person/jakobsson_mattias> ; # Mattias Jakobsson
   schema:contributor <http://experiment.worldcat.org/entity/work/data/4837148870#Person/ramsay_michele> ; # Michele Ramsay
   schema:datePublished "2018" ;
   schema:description "The origin of humans lies in Africa, as has been shown by archaeology, paleontology and genetics. Here, we can find the largest genetic diversity and the deepest split among human populations. African genetic diversity has been shaped by a long and complex history. In this thesis, I applied population genomic methods to investigate different aspects of the demographic history of Africa, specifically northeast and southern Africa. Both of these regions are population melting-pots, with many historically known major migrations. In northeast African populations, Eurasian admixture in central, northern, and eastern Sudanese populations was identified to be of Middle Eastern origin and the admixture time coincides with the Arab expansion. In northeast Africa I also studied alleles associated with lactase persistence, the ability to digest milk at an adult age. A wide diversity of these alleles was detected in Sudan, most commonly among pastoralists. The presence of a Middle Eastern LP-allele and absence of a European LP-allele is consistent with the admixture pattern observed in the first paper. I deciphered the patterns of genetic admixture in the Afrikaner population of South Africa and compared admixture patterns of the X-chromosome and autosomes to disentangle sex-biased admixture in southern African populations. The Afrikaner were shown to carry on average 5% non-European admixture, mostly from Khoe-San, East and South Asian sources. The admixture was sex-biased, with larger contributions from European males and admixture with Africans can be dated to 9-10 generations ago – fitting previous genealogical estimates of the age and the history of the population. Bantu-speaker/Khoe-San contact shows a pattern of female Bantu-speaker bias, which is conflicting with previous mtDNA and Y-chromosome studies. A change in mate-choice over time could explain this discrepancy. This thesis contributes to a deeper understanding of African demographic history in general and of some previously understudied populations and geographic areas in particular." ;
   schema:exampleOfWork <http://worldcat.org/entity/work/id/4837148870> ;
   schema:inLanguage "en" ;
   schema:isPartOf <http://worldcat.org/issn/1651-6214> ; # Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology.
   schema:isSimilarTo <http://worldcat.org/entity/work/data/4837148870#CreativeWork/> ;
   schema:name "Population genetic history and patterns of admixture Examples from northeastern and southern Africa." ;
   schema:productID "1027085967" ;
   schema:publication <http://www.worldcat.org/title/-/oclc/1027085967#PublicationEvent/uppsalaacta_universitatis_upsaliensis2018> ;
   schema:publisher <http://experiment.worldcat.org/entity/work/data/4837148870#Organization/uppsala_universitet_teknisk_naturvetenskapliga_vetenskapsomradet> ; # Uppsala universitet Teknisk-naturvetenskapliga vetenskapsområdet.
   schema:publisher <http://experiment.worldcat.org/entity/work/data/4837148870#Agent/acta_universitatis_upsaliensis> ; # Acta Universitatis Upsaliensis
   schema:url <http://uu.diva-portal.org/smash/get/diva2:1165836/FULLTEXT01> ;
   schema:url <http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-335214> ;
   wdrs:describedby <http://www.worldcat.org/title/-/oclc/1027085967> ;
    .


Related Entities

<http://experiment.worldcat.org/entity/work/data/4837148870#Agent/acta_universitatis_upsaliensis> # Acta Universitatis Upsaliensis
    a bgn:Agent ;
   schema:name "Acta Universitatis Upsaliensis" ;
    .

<http://experiment.worldcat.org/entity/work/data/4837148870#Organization/uppsala_universitet_teknisk_naturvetenskapliga_vetenskapsomradet> # Uppsala universitet Teknisk-naturvetenskapliga vetenskapsområdet.
    a schema:Organization ;
   schema:name "Uppsala universitet Teknisk-naturvetenskapliga vetenskapsområdet." ;
    .

<http://experiment.worldcat.org/entity/work/data/4837148870#Person/hollfelder_nina_1985> # Nina Hollfelder
    a schema:Person ;
   schema:birthDate "1985" ;
   schema:familyName "Hollfelder" ;
   schema:givenName "Nina" ;
   schema:name "Nina Hollfelder" ;
    .

<http://experiment.worldcat.org/entity/work/data/4837148870#Person/jakobsson_mattias> # Mattias Jakobsson
    a schema:Person ;
   schema:familyName "Jakobsson" ;
   schema:givenName "Mattias" ;
   schema:name "Mattias Jakobsson" ;
    .

<http://experiment.worldcat.org/entity/work/data/4837148870#Person/ramsay_michele> # Michele Ramsay
    a schema:Person ;
   schema:familyName "Ramsay" ;
   schema:givenName "Michele" ;
   schema:name "Michele Ramsay" ;
    .

<http://experiment.worldcat.org/entity/work/data/4837148870#Thing/genetic_admixture> # genetic admixture
    a schema:Thing ;
   schema:name "genetic admixture" ;
    .

<http://experiment.worldcat.org/entity/work/data/4837148870#Thing/genomic_variation> # genomic variation
    a schema:Thing ;
   schema:name "genomic variation" ;
    .

<http://experiment.worldcat.org/entity/work/data/4837148870#Thing/human_evolutionary_genetics> # human evolutionary genetics
    a schema:Thing ;
   schema:name "human evolutionary genetics" ;
    .

<http://experiment.worldcat.org/entity/work/data/4837148870#Thing/lactase_persistence> # lactase persistence
    a schema:Thing ;
   schema:name "lactase persistence" ;
    .

<http://experiment.worldcat.org/entity/work/data/4837148870#Thing/population_genomics> # population genomics
    a schema:Thing ;
   schema:name "population genomics" ;
    .

<http://experiment.worldcat.org/entity/work/data/4837148870#Thing/population_structure> # population structure
    a schema:Thing ;
   schema:name "population structure" ;
    .

<http://experiment.worldcat.org/entity/work/data/4837148870#Thing/sex_biased_admixture> # sex-biased admixture
    a schema:Thing ;
   schema:name "sex-biased admixture" ;
    .

<http://experiment.worldcat.org/entity/work/data/4837148870#Topic/bioinformatics_computational_biology> # Bioinformatics (Computational Biology)
    a schema:Intangible ;
   schema:name "Bioinformatics (Computational Biology)" ;
    .

<http://experiment.worldcat.org/entity/work/data/4837148870#Topic/bioinformatik_berakningsbiologi> # Bioinformatik (beräkningsbiologi)
    a schema:Intangible ;
   schema:name "Bioinformatik (beräkningsbiologi)" ;
    .

<http://experiment.worldcat.org/entity/work/data/4837148870#Topic/biologi_med_inriktning_mot_evolutionar_organismbiologi> # Biologi med inriktning mot evolutionär organismbiologi
    a schema:Intangible ;
   schema:name "Biologi med inriktning mot evolutionär organismbiologi" ;
    .

<http://experiment.worldcat.org/entity/work/data/4837148870#Topic/biological_sciences> # Biological Sciences
    a schema:Intangible ;
   schema:name "Biological Sciences" ;
    .

<http://experiment.worldcat.org/entity/work/data/4837148870#Topic/biologiska_vetenskaper> # Biologiska vetenskaper
    a schema:Intangible ;
   schema:name "Biologiska vetenskaper" ;
    .

<http://experiment.worldcat.org/entity/work/data/4837148870#Topic/biology_with_specialization_in_evolutionary_organismal_biology> # Biology with specialization in Evolutionary Organismal Biology
    a schema:Intangible ;
   schema:name "Biology with specialization in Evolutionary Organismal Biology" ;
    .

<http://experiment.worldcat.org/entity/work/data/4837148870#Topic/computer_and_information_science> # Computer and Information Science
    a schema:Intangible ;
   schema:name "Computer and Information Science" ;
    .

<http://experiment.worldcat.org/entity/work/data/4837148870#Topic/data_och_informationsvetenskap> # Data- och informationsvetenskap
    a schema:Intangible ;
   schema:name "Data- och informationsvetenskap" ;
    .

<http://experiment.worldcat.org/entity/work/data/4837148870#Topic/evolutionary_biology> # Evolutionary Biology
    a schema:Intangible ;
   schema:name "Evolutionary Biology" ;
    .

<http://worldcat.org/entity/work/data/4837148870#CreativeWork/>
    a schema:CreativeWork ;
   schema:description "Annat format" ;
   schema:isSimilarTo <http://www.worldcat.org/oclc/1027085967> ; # Population genetic history and patterns of admixture Examples from northeastern and southern Africa.
    .

<http://worldcat.org/issn/1651-6214> # Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology.
    a bgn:PublicationSeries ;
   schema:hasPart <http://www.worldcat.org/oclc/1027085967> ; # Population genetic history and patterns of admixture Examples from northeastern and southern Africa.
   schema:issn "1651-6214" ;
   schema:name "Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology." ;
   schema:name "Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology" ;
    .

<http://www.worldcat.org/title/-/oclc/1027085967>
    a genont:InformationResource, genont:ContentTypeGenericResource ;
   schema:about <http://www.worldcat.org/oclc/1027085967> ; # Population genetic history and patterns of admixture Examples from northeastern and southern Africa.
   schema:dateModified "2018-11-10" ;
   void:inDataset <http://purl.oclc.org/dataset/WorldCat> ;
    .


Content-negotiable representations

Close Window

Please sign in to WorldCat 

Don't have an account? You can easily create a free account.