skip to content
Practical radiobiology for proton therapy planning Preview this item
ClosePreview this item
Checking...

Practical radiobiology for proton therapy planning

Author: Bleddyn Jones; Institute of Physics (Great Britain),
Publisher: Bristol [England] (Temple Circus, Temple Way, Bristol BS1 6HG, UK) : IOP Publishing, [2017]
Series: IOP expanding physics.; Series in physics and engineering in medicine and biology.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Practical Radiobiology for Proton Therapy Planning covers the principles, advantages and potential pitfalls that occur in proton therapy, especially its radiobiological modelling applications. This book is intended to educate, inform and to stimulate further research questions. Additionally, it will help proton therapy centres when designing new treatments or when unintended errors or delays occur. The clear  Read more...
Rating:

(not yet rated) 0 with reviews - Be the first.

Subjects
More like this

Find a copy online

Links to this item

Find a copy in the library

&AllPage.SpinnerRetrieving; Finding libraries that hold this item...

Details

Genre/Form: Electronic books
Additional Physical Format: Print version:
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Bleddyn Jones; Institute of Physics (Great Britain),
ISBN: 9780750313384 0750313382 9780750313407 0750313404 9780750319232 0750319232
OCLC Number: 1019445699
Notes: "Version: 20171201"--Title page verso.
Title from PDF title page (viewed on January 11, 2018).
Description: 1 online resource : illustrations (some color)
Contents: 1. Particle physics for biological interactions --
1.1. Physical beam parameters, essential dosimetry and reference (or control) radiation requirements for RBE studies --
1.2. Physics interacting with biology 2. The essential radiobiology background --
2.1. Introduction --
2.2. Background and models --
2.3. The [alpha]/[beta] ratio and its choice for modelling particle therapies 3. Some important medical and surgical considerations, including clinical trials --
3.1. Introduction --
3.2. Surgery --
3.3. Cytotoxic chemotherapies --
3.4. Age and other medical conditions --
3.5. Interpretation of the case histories and literature --
3.6. Clinical trials --
3.7. Ethical issues --
3.8. Mixed endpoints --
3.9. The importance of follow-up --
3.10. Publication bias --
3.11. Some future prospects 4. Treatment planning and further medical perspectives --
4.1. Introduction --
4.2. Treatment planning processes --
4.3. The important interaction of RBE issues with the marginal target volumes --
4.4. Comparative planning studies --
4.5. Trade-off situations in comparative treatment planning --
4.5.1 Changes in the treatment plan --
4.6. How to accommodate assumed errors in the RBE --
4.7. The product of LET and dose 5. Historical development of radiotherapy including what was learned from fast neutrons --
5.1. Introduction --
5.2. A brief synopsis --
5.3. Neutron therapy --
5.4. More recent developments based on neutron studies --
5.5. Some important conclusions 6. Fractionation --
6.1. Introduction and background radiobiology --
6.2. A brief history of fractionation --
6.3. Modelling of fractionation --
6.4. RBE and dose per fraction --
6.5. Effects of regions of higher and lower dose per fraction relative to the prescribed dose for different fractionation patterns --
6.6. Taking RBE uncertainty into account in fractionation --
6.7. The use of the LQ model with large fraction sizes --
6.8. Optimisation of fractionation using calculus methods --
6.9. Other contributions to fractionation --
6.10. Summary 7. The case for using a variable proton RBE --
7.1. Introduction --
7.2. Arguments to preserve the status quo or avoid using RBE --
7.3. Justification of a variable RBE --
7.4. Further considerations 8. A general RBE simple efficiency model for protons and light ions --
8.1. Introduction --
8.2. The experimental data and its limitations --
8.3. Description of the Z-specific model --
8.4. The graphical results --
8.5. Conclusions and what remains to be done 9. Inclusion of the energy-efficiency LET and RBE model in proton therapy --
9.1. Introduction --
9.2. RBE uncertainties --
9.3. Description of the quantitative model --
9.4. Some comparisons with experimental data sets --
9.5. Two clinical examples where PBT could be suboptimal --
9.6. Prediction of tumour response from the RBE increment --
9.7. Concluding discussion 10. Compensating for elapsed time : unintended treatment interruptions and re-treatments --
10.1. Introduction --
10.2. Unintended treatment interruptions --
10.3. Summary for unintended treatment gap corrections --
10.4. Re-treatments 11. Errors of Bragg peak positioning and their radiobiological correction --
11.1. Introduction --
11.2. Brief description of methods --
11.3. Description of the model --
11.4. General discussion --
11.5. Conclusions 12. Additional considerations and conclusions --
12.1. Introduction --
12.2. Dose escalation where circumstances permit --
12.3. Simultaneous 'sensitisation' effects by new therapies --
12.4. Sensitivity analysis of the energy efficiency model --
12.5. What could be achieved in a single international laboratory dedicated to high LET radiobiology --
12.6. Conclusions.
Series Title: IOP expanding physics.; Series in physics and engineering in medicine and biology.
Responsibility: Bleddyn Jones.

Abstract:

Practical Radiobiology for Proton Therapy Planning covers the principles, advantages and potential pitfalls that occur in proton therapy, especially its radiobiological modelling applications. This book is intended to educate, inform and to stimulate further research questions. Additionally, it will help proton therapy centres when designing new treatments or when unintended errors or delays occur. The clear descriptions of useful equations for high LET particle beam applications, worked examples of many important clinical situations, and discussion of how proton therapy may be optimized are all important features of the text. This important book blends the relevant physics, biology and medical aspects of this multidisciplinary subject.

Reviews

User-contributed reviews
Retrieving GoodReads reviews...
Retrieving DOGObooks reviews...

Tags

Be the first.
Confirm this request

You may have already requested this item. Please select Ok if you would like to proceed with this request anyway.

Linked Data


Primary Entity

<http://www.worldcat.org/oclc/1019445699> # Practical radiobiology for proton therapy planning
    a schema:MediaObject, schema:Book, schema:CreativeWork ;
    library:oclcnum "1019445699" ;
    library:placeOfPublication <http://id.loc.gov/vocabulary/countries/enk> ;
    schema:about <http://experiment.worldcat.org/entity/work/data/4710877471#Topic/medical_radiology_radiotherapy_&_nuclear_medicine> ; # MEDICAL--Radiology, Radiotherapy & Nuclear Medicine
    schema:about <http://experiment.worldcat.org/entity/work/data/4710877471#Topic/radiobiology> ; # Radiobiology
    schema:about <http://experiment.worldcat.org/entity/work/data/4710877471#Topic/proton_therapy> ; # Proton Therapy
    schema:about <http://experiment.worldcat.org/entity/work/data/4710877471#Topic/radiotherapy> ; # Radiotherapy
    schema:about <http://experiment.worldcat.org/entity/work/data/4710877471#Topic/medical_physics> ; # Medical physics
    schema:about <http://experiment.worldcat.org/entity/work/data/4710877471#Topic/protons_therapeutic_use> ; # Protons--Therapeutic use
    schema:about <http://experiment.worldcat.org/entity/work/data/4710877471#Topic/radiotherapy_methods> ; # Radiotherapy--methods
    schema:about <http://dewey.info/class/616.9940642/e23/> ;
    schema:author <http://experiment.worldcat.org/entity/work/data/4710877471#Person/jones_bleddyn> ; # Bleddyn Jones
    schema:bookFormat schema:EBook ;
    schema:datePublished "2017" ;
    schema:description "Practical Radiobiology for Proton Therapy Planning covers the principles, advantages and potential pitfalls that occur in proton therapy, especially its radiobiological modelling applications. This book is intended to educate, inform and to stimulate further research questions. Additionally, it will help proton therapy centres when designing new treatments or when unintended errors or delays occur. The clear descriptions of useful equations for high LET particle beam applications, worked examples of many important clinical situations, and discussion of how proton therapy may be optimized are all important features of the text. This important book blends the relevant physics, biology and medical aspects of this multidisciplinary subject."@en ;
    schema:description "1. Particle physics for biological interactions -- 1.1. Physical beam parameters, essential dosimetry and reference (or control) radiation requirements for RBE studies -- 1.2. Physics interacting with biology"@en ;
    schema:exampleOfWork <http://worldcat.org/entity/work/id/4710877471> ;
    schema:genre "Electronic books"@en ;
    schema:inLanguage "en" ;
    schema:isPartOf <http://experiment.worldcat.org/entity/work/data/4710877471#Series/iop_expanding_physics> ; # IOP expanding physics.
    schema:isPartOf <http://experiment.worldcat.org/entity/work/data/4710877471#Series/series_in_physics_and_engineering_in_medicine_and_biology> ; # Series in physics and engineering in medicine and biology.
    schema:isPartOf <http://worldcat.org/issn/2053-2563> ; # IOP expanding physics,
    schema:isSimilarTo <http://worldcat.org/entity/work/data/4710877471#CreativeWork/> ;
    schema:name "Practical radiobiology for proton therapy planning"@en ;
    schema:productID "1019445699" ;
    schema:publisher <http://experiment.worldcat.org/entity/work/data/4710877471#Organization/institute_of_physics_great_britain> ; # Institute of Physics (Great Britain),
    schema:url <https://iopscience.iop.org/book/978-0-7503-1338-4> ;
    schema:url <http://VH7QX3XE2P.search.serialssolutions.com/?V=1.0&L=VH7QX3XE2P&S=AC_T_B&C=Practical%20Radiobiology%20for%20Proton%20Therapy%20Planning&T=marc&tab=BOOKS> ;
    schema:url <http://iopscience.iop.org/book/978-0-7503-1338-4> ;
    schema:workExample <http://worldcat.org/isbn/9780750313407> ;
    schema:workExample <http://worldcat.org/isbn/9780750313384> ;
    schema:workExample <http://dx.doi.org/10.1088/978-0-7503-1338-4> ;
    schema:workExample <http://worldcat.org/isbn/9780750319232> ;
    wdrs:describedby <http://www.worldcat.org/title/-/oclc/1019445699> ;
    .


Related Entities

<http://experiment.worldcat.org/entity/work/data/4710877471#Organization/institute_of_physics_great_britain> # Institute of Physics (Great Britain),
    a schema:Organization ;
    schema:name "Institute of Physics (Great Britain)," ;
    .

<http://experiment.worldcat.org/entity/work/data/4710877471#Person/jones_bleddyn> # Bleddyn Jones
    a schema:Person ;
    schema:familyName "Jones" ;
    schema:givenName "Bleddyn" ;
    schema:name "Bleddyn Jones" ;
    .

<http://experiment.worldcat.org/entity/work/data/4710877471#Series/iop_expanding_physics> # IOP expanding physics.
    a bgn:PublicationSeries ;
    schema:hasPart <http://www.worldcat.org/oclc/1019445699> ; # Practical radiobiology for proton therapy planning
    schema:name "IOP expanding physics." ;
    .

<http://experiment.worldcat.org/entity/work/data/4710877471#Series/series_in_physics_and_engineering_in_medicine_and_biology> # Series in physics and engineering in medicine and biology.
    a bgn:PublicationSeries ;
    schema:hasPart <http://www.worldcat.org/oclc/1019445699> ; # Practical radiobiology for proton therapy planning
    schema:name "Series in physics and engineering in medicine and biology." ;
    schema:name "Series in physics and engineering in medicine and biology" ;
    .

<http://experiment.worldcat.org/entity/work/data/4710877471#Topic/medical_radiology_radiotherapy_&_nuclear_medicine> # MEDICAL--Radiology, Radiotherapy & Nuclear Medicine
    a schema:Intangible ;
    schema:name "MEDICAL--Radiology, Radiotherapy & Nuclear Medicine"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/4710877471#Topic/protons_therapeutic_use> # Protons--Therapeutic use
    a schema:Intangible ;
    schema:name "Protons--Therapeutic use"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/4710877471#Topic/radiotherapy_methods> # Radiotherapy--methods
    a schema:Intangible ;
    schema:name "Radiotherapy--methods"@en ;
    .

<http://iopscience.iop.org/book/978-0-7503-1338-4>
    rdfs:comment "eBook available for UOIT via IOP. Click link to access" ;
    rdfs:comment "IOPscience" ;
    .

<http://worldcat.org/entity/work/data/4710877471#CreativeWork/>
    a schema:CreativeWork ;
    schema:description "Print version:" ;
    schema:isSimilarTo <http://www.worldcat.org/oclc/1019445699> ; # Practical radiobiology for proton therapy planning
    .

<http://worldcat.org/isbn/9780750313384>
    a schema:ProductModel ;
    schema:isbn "0750313382" ;
    schema:isbn "9780750313384" ;
    .

<http://worldcat.org/isbn/9780750313407>
    a schema:ProductModel ;
    schema:isbn "0750313404" ;
    schema:isbn "9780750313407" ;
    .

<http://worldcat.org/isbn/9780750319232>
    a schema:ProductModel ;
    schema:isbn "0750319232" ;
    schema:isbn "9780750319232" ;
    .

<http://worldcat.org/issn/2053-2563> # IOP expanding physics,
    a bgn:PublicationSeries ;
    schema:hasPart <http://www.worldcat.org/oclc/1019445699> ; # Practical radiobiology for proton therapy planning
    schema:issn "2053-2563" ;
    schema:name "IOP expanding physics," ;
    .


Content-negotiable representations

Close Window

Please sign in to WorldCat 

Don't have an account? You can easily create a free account.