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Precision molecular pathology of uterine cancer

Author: Michael T Deavers; Donna M Coffey
Publisher: Cham : Springer, 2017.
Series: Molecular pathology library series.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
This text provides a comprehensive review for practicing pathologists to understand the molecular biology, diagnostics, and predictive markers and implications for therapy of uterine cancer. While molecular based therapeutic strategies for uterine cancer are not as well developed as for some other organ sites, these are the most common gynecologic malignancies and there have been many important recent developments  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Precision molecular pathology of uterine cancer.
Cham : Springer, 2017
(OCoLC)982651633
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Michael T Deavers; Donna M Coffey
ISBN: 9783319579856 3319579851
OCLC Number: 1008962916
Description: 1 online resource.
Contents: ""Contents""; ""Contributors""; ""Introduction""; ""1 Endometrial Carcinoma: Precursor Lesions and Molecular Profiles""; ""Introduction""; ""Endometrioid Carcinoma (Type 1)""; ""Precursor Lesions""; ""Uterine Serous Carcinoma (Type 2)""; ""Precursor Lesions""; ""Molecular Signature""; ""Molecular Alterations in Endometrioid Carcinoma""; ""Molecular Alterations in Serous Carcinoma""; ""Genomic Characterization of USC""; ""Conclusion""; ""References""; ""Endometrial Carcinoma""; ""2 Classification of Endometrial Carcinoma""; ""A Putative Pathogenetic Model for Endometrial Carcinoma"" ""Histopathologic Classification""""Endometrioid Adenocarcinoma""; ""Mucinous Carcinoma""; ""Serous Carcinoma""; ""Clear Cell Carcinoma""; ""Mixed Carcinoma""; ""Undifferentiated Carcinoma""; ""Neuroendocrine Tumors""; ""Staging of Endometrial Carcinoma""; ""Prognostic Factors""; ""Hereditary Endometrial Carcinoma""; ""References""; ""3 Immunohistochemical Markers in Endometrial Carcinoma""; ""Endometrial Carcinoma Versus Extramüllerian Primaries""; ""Endometrial Carcinoma Versus Other Müllerian Primaries""; ""Subtyping of Endometrial Carcinoma"" ""Endometrial Carcinoma and Lynch Syndrome""""Acknowledgements""; ""References""; ""4 Molecular Pathology of Endometrioid Adenocarcinoma""; ""Introduction""; ""PI3K/AKT Pathway""; ""PTEN""; ""PIK3CA""; ""PIK3R1 and PIK3R2""; ""ARID1A""; ""KRAS""; ""CTNNB1""; ""TP53""; ""Microsatellite Instability""; ""POLE""; ""The Cancer Genome Atlas""; ""Acknowledgement""; ""References""; ""5 The Molecular Pathology of Serous Endometrial Cancer""; ""Introduction""; ""Introduction to the Molecular Pathology of SEC""; ""TP53 Aberrations in SEC""; ""PI3K Pathway Aberrations in SEC"" ""PI3K Pathway Aberrations as Therapeutic Targets in SEC""""HER2 (ERBB2) Aberrations in SEC""; ""Î#x97;Î#x95;R2 as a Therapeutic Target in SEC""; ""FBXW7 Aberrations in SEC""; ""PPP2R1A Mutations in SEC""; ""CHD4 Mutations in SEC""; ""SPOP Mutations in SEC""; ""TAF1 Mutations in SEC""; ""Novel Clinical Trial Designs""; ""Summary and Conclusion""; ""References""; ""6 Uterine Clear Cell Carcinoma""; ""Introduction""; ""Histopathologic Features""; ""Immunophenotypic Features""; ""Genetic Features""; ""Biological Function of Immunohistochemical and Genetic Markers""; ""HNF-1β""; ""Napsin A"" ""Bax and Bcl-2""""TP53/p53""; ""ARID1A/BAF250a""; ""PPP2R1A""; ""PIK3CA""; ""PTEN""; ""Precursor Lesion and Oncogenesis""; ""Similarity and Differences of Molecular Features of Endometrial and Ovarian Clear Cell Carcinoma""; ""Conclusion and Future Directions""; ""References""; ""7 Mucinous Adenocarcinoma of the Endometrium""; ""Clinical Features""; ""Histopathologic Features""; ""Immunohistochemical Profile""; ""Differential Diagnosis""; ""Papillary Mucinous Metaplasia, a Possible Precursor of Mucinous Endometrial Adenocarcinoma""; ""Pyloric/Gastric Metaplasia of the Endometrium""
Series Title: Molecular pathology library series.
Responsibility: Michael T. Deavers, Donna M. Coffey, editors.

Abstract:

This text provides a comprehensive review for practicing pathologists to understand the molecular biology, diagnostics, and predictive markers and implications for therapy of uterine cancer.  Read more...

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