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Principles of animal extrapolation

Author: Edward J Calabrese
Publisher: Boca Raton : CRC Press, Taylor & Francis Group, [2018]
Series: CRC Press Revivals.
Edition/Format:   eBook : Document : EnglishView all editions and formats
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Calabrese, Edward J.
Principles of Animal Extrapolation (1991)
Milton : CRC Press,c2017
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Edward J Calabrese
ISBN: 9781351359047 1351359045 9781351359030 1351359037
OCLC Number: 1020692141
Notes: Description based upon print version of record.
C. White Blood Cells: Interspecies Differences in the Detoxification of Hydrogen Peroxide by Polymorphonuclear Leukocytes
Description: 1 online resource (616 p.)
Contents: Cover; Title Page; Copyright Page; Preface; Contents; 1. Animal Extrapolation: An Introduction; A. Federal Legislation and Predictive Toxicology; B. The Early Use of Animal Models; C. How Much Testing Is Needed?; D. Are Perfect Testing Schemes Possible?; E. Inadequacies of Present Predictive Schemes; F. Animal Rights, Humane Considerations, and Human Needs; G. Educating the Public: Perception Versus Reality; H. Regulatory Needs; 2. Absorption: Interspecies Differences; A. The Gastrointestinal Tract; Introduction; Inorganic Substances; Organic Substances Use of the Rabbit in Gastrointestinal Tract Absorption StudiesAbsorption: A Perspective on Interspecies Differences; Appendix 2-1: Interspecies Comparison of Absorption Rates for Selected Drugs; B. Dermal Absorption; Introduction; In Vitro Studies; In Vivo Studies; Environmental Pollutants; The Hairless Dog: A Potential Model?; The Basis of Interspecies Differences in Percutaneous Absorption; C. Respiratory Tract Absorption; Interspecies Comparisons: The Role of Scaling Factors; Interspecies Differences in Particle Deposition; Interspecies Differences in Mucus Flow Patterns Interspecies Differences in Effective Doses Versus Ambient LevelsInterspecies Differences in Tracheobronchial Tree Mucus-Secreting Glands; Lung Histamine Release: Animal Models; Knowledge of Pollutant Characteristics in the Selection of an Animal Model; Summary; 3. Intestinal Microflora; Introduction; Interspecies Differences; Summary; 4. Tissue Distribution: Interspecies Differences; A. Protein Binding; Introduction; Inorganic Substances; Organic Substances; Protein Binding: A Perspective; B. Biliary Excretion; Introduction; Biliary Excretion in the R at; Interspecies Differences Human PerspectivesSummary; C. The Blood-Brain Barrier: The Toxicological Implications of Interspecies Differences in Maturation; D. Interspecies Differences in the Tissue Distribution of Mercury; Mercury; Paraquat; 5. Comparative Metabolism: The Principal Cause of Differential Susceptibility to Toxic and Carcinogenic Agents; A. General Principles; Introduction; Phylogeny and Toxicology; Xenobiotic Metabolism: An Overview; Interspecies Differences in Phase I Reactions; Interspecies Differences in Phase II Reactions: Conjugations; B. Organophosphate Insecticides: A Specific Application IntroductionOrganophosphate Metabolism; C. Other Examples; Interspecies Differences for DDT-Induced Carcinogenicity; Cyanide Toxicity; 6. A Reevaluation of the Rat as a Laboratory Animal; 7. Animal Models for Selected High-Risk Groups; A. Introduction; B. Hereditary Blood Disorders; Acatalasemia; G-6-PD Deficiency; Methemoglobin Formation; The Effects of Environmental Oxidants on Human Erythrocytes; The Sickle Cell Trait and Anemia; Hemoglobin Variants and Susceptibility to Carboxyhemoglobin Formation; Thalassemia
Series Title: CRC Press Revivals.
Responsibility: Edward J. Calabrese.

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