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Principles of characterizing and applying human exposure models.

Author: International Program on Chemical Safety.; World Health Organization.; International Labour Organisation.; United Nations Environment Programme.; Inter-Organization Programme for the Sound Management of Chemicals.
Publisher: Geneva : World Health Organization, 2005.
Series: Harmonization Project document, no. 3.
Edition/Format:   eBook : Document : International government publication : EnglishView all editions and formats
Summary:
The objective of this manual is to provide guidance to risk assessors on the use of quantitative toxicokinetic and toxicodynamic data to address interspecies and interindividual differences in dose and concentration-response assessment. Section 1 focuses on the relevance of this guidance in the context of the broader risk assessment paradigm and other initiatives of the International Program on Chemical Safety  Read more...
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Genre/Form: Electronic book
Electronic books
Additional Physical Format: Print version:
Principles of characterizing and applying human exposure models.
Geneva : World Health Organization, 2005
(OCoLC)76789287
Material Type: Document, Government publication, International government publication, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: International Program on Chemical Safety.; World Health Organization.; International Labour Organisation.; United Nations Environment Programme.; Inter-Organization Programme for the Sound Management of Chemicals.
ISBN: 9789240682047 924068204X
OCLC Number: 127108452
Notes: "IPCS International Programme on Chemical Safety"--Cover.
"This project was conducted within the IPCS project on the Harmonization of Approaches to the Assessment of Risk from Exposure to Chemicals."
"Published under the joint sponsorship of the World Health Organization, the International Labour Organization and the United Nations Environment Programme, and produced within the framework of the Inter-Oganization Programme for the Sound Management of Chemicals."
Description: 1 online resource (iv, 70 pages) : illustrations.
Contents: Introduction --
Aspects of exposure modelling --
Concentration, exposure and dose models --
Recommendations for characterizing exposure models.
Series Title: Harmonization Project document, no. 3.

Abstract:

The objective of this manual is to provide guidance to risk assessors on the use of quantitative toxicokinetic and toxicodynamic data to address interspecies and interindividual differences in dose and concentration-response assessment. Section 1 focuses on the relevance of this guidance in the context of the broader risk assessment paradigm and other initiatives of the International Program on Chemical Safety (IPCS) project on the Harmonization of Approaches to the Assessment of Risk from Exposure to Chemicals. Technical background material is presented in section 2, followed by generic guidance for the development of chemical-specific adjustment factors in section 3 and accompanying summary figures. Illustrative case-studies are included in an Appendix, and a glossary of terms is also provided.--Publisher's description.

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