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Process chemistry in the pharmaceutical industry. Volume 2, Challenges in an ever changing climate

Author: Kumar G Gadamasetti; Tamim Braish
Publisher: Boca Raton : CRC Press, ©2008.
Edition/Format:   Print book : EnglishView all editions and formats
Summary:

Explores process research and development methods applied to synthesis, clinical trials, and commercial drug candidates in process chemistry. This volume discusses approaches to synthetic processes,  Read more...

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Material Type: Internet resource
Document Type: Book, Internet Resource
All Authors / Contributors: Kumar G Gadamasetti; Tamim Braish
ISBN: 9780849390517 0849390516
OCLC Number: 132681462
Description: xxiv, 494 pages, 16 unnumbered pages of plates : illustrations (some color) ; 27 cm
Contents: Ch. 1. Process Chemistry in the Pharmaceutical Industry: Challenges in an Ever Changing Climate --
An Overview / Kumar Gadamasetti --
Ch. 2. Emerging Trends in Process Chemistry / Tamim F. Braish, Fons De Knaep and Kumar Gadamasetti --
Ch. 3. Varenicline: Discovery Synthesis and Process Chemistry Developments / Jotham W. Coe, Harry A. Watson, Jr. and Robert A. Singer --
Ch. 4. SUTENT Story / Rajappa Vaidyanathan --
Ch. 5. Efficient and Scalable Process for the Preparation of a Potent MC4 Receptor Agonist / Cecile Savarin, John Chung, Jerry A. Murry, Raymond J. Cvetovich, Chris McWilliams, Dave Hughes, Joseph Amato, Genevieve Boice, Karen Conrad, Edward Corley, Robert Reamer and Lisa DiMichele --
Ch. 6. Process Research and Development of LY414197, a 5HT[subscript 2B] Antagonist / Alfio Borghese and Alain Merschaert --
Ch. 7. To Overcome the Hurdles: Coping with the Synthesis of Robalzotan, a Complex Chroman Antidepressant / Hans-Jurgen Federsel and Anders Sveno --
Ch. 8. Chiral Amine Synthesis --
Strategies, Examples, and Limitations / Thomas C. Nugent --
Ch. 9. Unnatural Amino Acids / David J. Ager --
Ch. 10. Chemical Development of a Potential Manufacturing Route to the Endothelin Antagonists UK-350,926 and UK-349,862 / Christopher P. Ashcroft, Stephen Challenger, Andrew M. Derrick, Yousef Hajikarimian and Nicholas M. Thomson --
Ch. 11. Cefovecin Sodium: A Single-Dose Long-Acting Antibiotic for Use in Companion Animals / Timothy Norris --
Ch. 12. Lithium-Halogen Exchange Reaction in Process Chemistry / William F. Bailey and Terry L. Rathman --
Ch. 13. Oxetan-3-one: Chemistry and Synthesis / Georg Wuitschik, Erick M. Carreira, Mark Rogers-Evans and Klaus Muller --
Ch. 14. Well-Defined (NHC)Pd (II) Complexes and Their Use in C-C and C-N Bond-Forming Reactions / Oscar Navarro and Steven P. Nolan --
Ch. 15. Toward Truly Efficient Organic Reactions in Water / Chikako Ogawa and Shu Kobayashi.
Other Titles: Challenges in an ever changing climate
Responsibility: edited by Kumar Gadamasetti, Tamim Braish.
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