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The process of new drug discovery and development

Author: Charles G Smith; James O'Donnell, Pharm. D.
Publisher: New York : Informa Healthcare, ©2006.
Edition/Format:   Print book : English : 2nd edView all editions and formats
Summary:
This is a practical methodology for maximising the ability of a multidisciplinary research team to discover and bring new drugs to the marketplace. This second edition includes updated discussions and a review of scientific methodologies which were unknown in 1992.
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Genre/Form: History
Material Type: Internet resource
Document Type: Book, Internet Resource
All Authors / Contributors: Charles G Smith; James O'Donnell, Pharm. D.
ISBN: 0849327792 9780849327797
OCLC Number: 62736887
Notes: Revised edition of: The process of new drug discovery and development / Charles G. Smith. c1992.
Description: 668 pages : illustrations ; 27 cm
Contents: Overview of the current process of new drug discovery and development / Charles G. Smith and James T. O'Donnell --
Integrated drug product development: from lead candidate selection to life-cycle management / Madhu Pudipeddi, Abu T.M. Serajuddin, and Daniel Mufson --
The impact of combinatorial chemistry on drug discovery / Michael H. Rabinowitz and Nigel Shankley --
High-throughput screening: enabling and influencing the process of drug discovery / Carol Ann Homon and Richard M. Nelson --
Pharmacological and pharmaceutical profiling: new trends / Joanne Bowes [and others] --
Cell-based analysis of drug response using moving optical gradient fields / Jeff M. Hall [and others]. Patient-derived primary cells in high-throughput differential antitumor screens: let the patients be the guide / Irwin A. Braude --
The evolving role of the caco-2 cell model to estimate intestinal absorption potential and elucidate transport mechanisms / Jibin Li and Ismael J. Hidalgo. The promise of metabonomics in drug discovery / Harold J. Kwalwasser and Pauline Gee --
Pharmacogenetics and pharmacogenomics in drug development and regulatory decision-making: report of the first FDA-PWG-PhRMA-druSafe workshop / Lawrence J. Lesko [and others] --
Drugs from molecular targets for CNS and neurodegenerative diseases / William T. Comer and Gönül Veliçelebi --
Safety pharmacology / Jean-Pierre Valentin and Tim G. Hammond --
Nonclinical drug safety assessment / Frederick E. Reno --
Preclinical genotoxicity testing: past, present and future / Richard H.C. San --
The need for animals in biomedical research / Charles G. Smith --
Defining the actual research approach to the new drug substance / Charles G. Smith --
Pharmacokinetics: pharmacodynamics in new drug development / Sarfaraz K. Niazi. Pharmaceutics and compounding issues in new drug development and marketing / Loyd V. Allen --
Late stage and process development activities / Charles G. Smith --
Contract research organizations: role and function in new drug development / F. Richard Nichol --
The front lines of clinical research: the industry / Lori Nesbitt --
Horizons for cancer chemotherapy (and nonchemotherapy) / Daniel D. Von Hoff --
Human immunodeficiency virus/acquired immune deficiency syndrome: clinical testing challenges / Vincent Idemyor --
Common technical document: the changing face of the new drug application / Justina A. Molzon --
Electronic publishing / Heather L. Wallace --
The important role of pharmacists in a complex risk-management system: managing the risks from medical product use by focusing on patient education, monitoring, and adverse event reporting / Justina A. Molzon --
Liability, litigation, and lessons in new drug development / James T. O'Donnell --
Problems in the nondrug marketplace / Stephen Barrett --
Patents and new product development in the pharmaceutical and biotechnology industries / Henry Grabowski. The pharmaceutical revolution: drug discovery and development / John C. Somberg --
The discovery of Rituxan / Mitchell E. Reff --
Funding the birth of a drug: lessons from the sell side / Howard E. Greene --
Innovations for the drug development pathway: what is needed now / Janet Woodcock --
Managing R & D uncertainty and maximizing the commercial potential of pharmaceutical compounds using the dynamic modeling framework / Mark Paich [and others].
Responsibility: edited by Charles G. Smith, James T. O'Donnell.
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Abstract:

This is a practical methodology for maximising the ability of a multidisciplinary research team to discover and bring new drugs to the marketplace. This second edition includes updated discussions and a review of scientific methodologies which were unknown in 1992.

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