Proteases : Structure and Function. (eBook, 2014) [WorldCat.org]
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Proteases : Structure and Function.

Author: Klaudia Brix; Walter Stöcker
Publisher: New York : Springer Feb. 2014.
Edition/Format:   eBook : Document : EnglishView all editions and formats
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Genre/Form: Electronic books
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Klaudia Brix; Walter Stöcker
ISBN: 9783709108840 3709108845
OCLC Number: 876284623
Target Audience: Scholarly & Professional
Description: 1 online resource (600 pages) : illustrations
Contents: 1 Protease families, evolution and mechanisms of action "Set the stage".- 1.1 Enzyme families, prototypes and catalytic mechanisms.- 1.2 Enzyme kinetics, mathematical modelling and perspectives.- 1.3 Structure determination and search for inhibitors.- 2 Regulation of proteolysis "Positioning and teaming-up to control activity".- 2.1 Compartmentalization of proteolysis.- 2.2 Biosynthesis of lysosomal proteases.- 2.3 Interactions of proteases and inhibitors / networking in the degradome.- 2.4 In vivo analysis of the protease and inhibitors concert.- 3 Proteases in development "Born to be right".- 3.1 Proteases for pattern formation during morphogenesis.- 3.2 Proteases in death pathways (apoptosis, necrosis).- 4 Proteases in physiology and pathophysiology "Cleave to function in health or to cause disease".- 4.1 Protein turnover and signaling functions (degrade to rebuild, remodel, process and mature for signalling).- 4.2 Proteases in control of physiology.- 4.3 Cancer: invasion and metastasis.- 4.4 Bacterial proteases.- 4.5 Viral proteases.

Abstract:

Proteolysis is an irreversible posttranslational modification affecting each and every protein from its biosynthesis to its degradation. In particular, we are becoming aware of the subtle role that  Read more...

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