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Protein misfolding

Author: Rossen Donev
Publisher: [Place of publication not identified] : Academic Press, 2020.
Series: Advances in protein chemistry and structural biology, v. 118.
Edition/Format:   eBook : Document : EnglishView all editions and formats
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Protein misfolding.
[Place of publication not identified] : Academic Press, 2020
(OCoLC)1108532687
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Rossen Donev
ISBN: 9780128177518 0128177519
OCLC Number: 1136154417
Description: 1 online resource
Contents: Front Cover --
Protein Misfolding --
Protein Misfolding --
Copyright --
Contents --
Contributors --
One --
Theoretical and computational advances in protein misfolding --
1. Introduction --
2. Mechanism of protein misfolding --
3. Simulations: atomistic and coarse grained models --
4. Atomistic simulations of early-stages monomers, small oligomers and end products of aggregation --
5. Coarse grained models --
6. Conclusions --
Acknowledgments --
References --
Two --
Combining molecular dynamics simulations and experimental analyses in protein misfolding --
1. Introduction 2. Basic concepts of protein misfolding and aggregation --
3. Biophysical analyses of protein misfolding --
3.1 X-ray diffraction and small-angle X-ray scattering --
3.2 Nuclear magnetic resonance analyses --
3.3 Transmission electron microscopy and cryomicroscopy --
3.4 Atomic force microscopy --
3.5 Optical characterization --
3.6 Mass-spectrometry --
4. Molecular simulations of misfolding proteins --
4.1 Atomistic modeling of proteins --
4.2 Force fields for protein and water models --
4.3 The challenges of system size and simulation time, and alternative approaches 4.4 Analysis of molecular dynamics trajectories --
5. Integrative approaches in understanding misfolding and aggregation --
5.1 Effects of mutations, truncations and insertions on protein structure and stability --
5.2 Intermediate states, oligomers, and molecular basis of aggregation --
5.3 Influence of extrinsic factors --
6. Open questions and challenges --
Acknowledgments --
References --
Three --
Mass spectrometric approaches for profiling protein folding and stability --
1. Introduction --
2. Terminology --
3. Quantitation in mass spectrometry --
3.1 Spectral counts 3.2 Label free quantification --
3.3 Targeted proteomics --
3.4 Stable isotopes --
3.5 Isobaric tags --
4. Fractionation methods for characterizing the destabilized proteome --
4.1 Thermal destabilization --
4.2 Isolation of aggresomes --
4.3 Conformational antibodies --
5. Enzymatic methods for identifying protein stability --
5.1 Limited proteolysis --
5.2 Ubiquitinylation --
6. Exploiting chemical reactivity to characterize protein stability --
6.1 Hydrogen-deuterium exchange --
6.2 FPOP --
6.3 SPROX --
6.4 Electrophilic profiling --
6.5 Crosslinking and mass spectrometry (XL-MS) --
7. Summary
Series Title: Advances in protein chemistry and structural biology, v. 118.
Responsibility: edited by Rossen Donev.

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