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Quantitative point-of-care troponin T measurement for diagnosis and prognosis in patients with a suspected acute myocardial infarction.
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Quantitative point-of-care troponin T measurement for diagnosis and prognosis in patients with a suspected acute myocardial infarction.

Author: C Stengaard Affiliation: Department of Cardiology, Aarhus University Hospital, Aarhus, Central Denmark Region, Denmark. Electronic address: carstengaard@hotmail.com.JT SørensenSA LadefogedEF ChristensenJF LassenAll authors
Edition/Format: Article Article : English
Publication:The American journal of cardiology, 2013 Nov 01; 112(9): 1361-6
Summary:
Improvement of prehospital triage is essential to ensure rapid management of patients with acute myocardial infarction (AMI). This study evaluates the feasibility of prehospital quantitative point-of-care cardiac troponin T (POC-cTnT) analysis, its ability to identify patients with AMI, and its capacity to predict mortality. The study was performed in the Central Denmark Region from May 2010 to May 2011. As a  Read more...
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Document Type: Article
All Authors / Contributors: C Stengaard Affiliation: Department of Cardiology, Aarhus University Hospital, Aarhus, Central Denmark Region, Denmark. Electronic address: carstengaard@hotmail.com.; JT Sørensen; SA Ladefoged; EF Christensen; JF Lassen; HE Bøtker; CJ Terkelsen; K Thygesen
ISSN:0002-9149
Language Note: English
Unique Identifier: 5534399988
Awards:

Abstract:

Improvement of prehospital triage is essential to ensure rapid management of patients with acute myocardial infarction (AMI). This study evaluates the feasibility of prehospital quantitative point-of-care cardiac troponin T (POC-cTnT) analysis, its ability to identify patients with AMI, and its capacity to predict mortality. The study was performed in the Central Denmark Region from May 2010 to May 2011. As a supplement to electrocardiography, a prehospital POC-cTnT measurement was performed by a paramedic in patients with suspected AMI. AMI was diagnosed according to the universal definition of myocardial infarction using the ninety-ninth percentile upper reference level as diagnostic cut point. The paramedics performed POC-cTnT measurements in 985 subjects with a symptom duration of 70 minutes (95% CI, 35 to 180); of whom, 200 (20%) had an AMI. The prehospital sample was obtained 88 minutes (range, 58 to 131) before the sample made on admission to the hospital. The sensitivity for detection of patients with an AMI was 39% (95% CI, 32% to 46%) and the diagnostic accuracy of the POC-cTnT values was 0.67 (95% CI, 0.64 to 0.71). Adjusted survival analysis showed a strong significant association between elevated prehospital POC-cTnT level above the detection level of 50 ng/L and mortality in patients with a suspected AMI irrespective of whether an AMI was diagnosed. In conclusion, large-scale quantitative prehospital POC-cTnT testing by paramedics is feasible. An elevated prehospital POC-cTnT value contains diagnostic information and is highly predictive of mortality in patients with a suspected AMI.

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