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Rescue of dying neurons by (R)-deprenyl in the MPTP-mouse model of Parkinson's disease does not include restoration of neostriatal dopamine.
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Rescue of dying neurons by (R)-deprenyl in the MPTP-mouse model of Parkinson's disease does not include restoration of neostriatal dopamine.

Author: SJ Steyn Affiliation: Harvey W. Peters Center for the Study of Parkinson's Disease, Department of Chemistry, Virginia Tech., Blacksburg, VA 24061-0212, USA.; K Castagnoli; Castagnoli N Jr
Edition/Format: Article Article : English
Publication:Annals of the New York Academy of Sciences, 2001 Jun; 939: 330-9
Other Databases: WorldCatWorldCat
Summary:
Chronic (8- to 10-week) administration of the selective, potent, and irreversible monoamine oxidase B inhibitor (R)-deprenyl has been shown to increase the tyrosine hydroxylase immunoreactivity in the substantia nigra of mice that had been treated three days earlier with a neurotoxic dose of the parkinsonian-inducing agent 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). This reported rescuing of lesioned  Read more...
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Details

Document Type: Article
All Authors / Contributors: SJ Steyn Affiliation: Harvey W. Peters Center for the Study of Parkinson's Disease, Department of Chemistry, Virginia Tech., Blacksburg, VA 24061-0212, USA.; K Castagnoli; Castagnoli N Jr
ISSN:0077-8923
Language Note: English
Unique Identifier: 120737141
Awards:

Abstract:

Chronic (8- to 10-week) administration of the selective, potent, and irreversible monoamine oxidase B inhibitor (R)-deprenyl has been shown to increase the tyrosine hydroxylase immunoreactivity in the substantia nigra of mice that had been treated three days earlier with a neurotoxic dose of the parkinsonian-inducing agent 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). This reported rescuing of lesioned nigrostriatal cell bodies by (R)-deprenyl prompted us to investigate if this (R)-deprenyl treatment also could restore neostriatal dopamine levels that are depleted by MPTP. The results of these experiments show that long term (8 or 10 weeks) treatment with (R)-deprenyl beginning three days post MPTP administration did not result in restoration of depleted neostriatal dopamine levels in C57BL/6 mice. We conclude that, although (R)-deprenyl may rescue MPTP-injured nigrostriatal neurons, it does not lead to functional recovery of these neurons as measured by the restoration of neostriatal dopamine levels.

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