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Resistance to targeted therapies in lymphomas

Author: Ana C Xavier; Mitchell S Cairo
Publisher: Cham : Springer, 2019.
Series: Resistance to targeted anti-cancer therapeutics, v. 21.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
This volume will review different classes of "target" drugs that have been developed, approved, or are under investigation in the field of lymphoma therapy. The discussion will not only be on the understanding of the mechanisms of action or clinical response of those agents, but also help the reader to understand the nature of lymphoma biology in patients who relapse or are refractor after exposure to those drugs.  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Xavier, Ana C.
Resistance to Targeted Therapies in Lymphomas
Cham : Springer,c2019
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Ana C Xavier; Mitchell S Cairo
ISBN: 9783030244248 3030244245
OCLC Number: 1120695308
Description: 1 online resource (220 p.).
Contents: Mechanisms of Glucocorticoid Response and Resistance in Lymphoid Malignancies --
Resistance to Monoclonal Antibody Therapeutics in Lymphoma --
Resistance to Antibody-Drug Conjugate --
Resistance to Proteasome Inhibitor Therapy in Non-Hodgkin Lymphoma --
Resistance to Histone Deacetylase Inhibitors in the Treatment of Lymphoma --
Resistance to Brutons Tyrosine Kinase Signaling Pathway Targeted Therapies --
Resistance to Checkpoint Blockade Inhibitors and Immunomodulatory Drugs --
Resistance to Bispecific T-cell Engagers and Bispecific Antibodies --
Resistance to Chimeric antigen receptor T-cell therapy --
Index.
Series Title: Resistance to targeted anti-cancer therapeutics, v. 21.
Responsibility: Ana C. Xavier, Mitchell S. Cairo, editors.

Abstract:

This volume will review different classes of "target" drugs that have been developed, approved, or are under investigation in the field of lymphoma therapy. The discussion will not only be on the understanding of the mechanisms of action or clinical response of those agents, but also help the reader to understand the nature of lymphoma biology in patients who relapse or are refractor after exposure to those drugs. Contributors will discuss what is currently known about mechanisms of tumor-related or host-related resistance, and how to overcome this resistance. This understanding is crucial given the dismal outcomes of patients with relapsed or refractory lymphomas. The book provides a unique opportunity to review and reflect on the recent successes and pitfalls of the modern lymphoma therapy era.

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