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Retrovirus-Cell Interactions

Author: Leslie J Parent
Publisher: London, United Kingdom ; San Diego, CA, United States : Academic Press is an imprint of Elsevier, [2018]
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Retrovirus-Cell Interactions provides an up-to-date review of the interactions between retroviruses and the cells they infect, offering a comprehensive understanding of how retroviruses hijack cellular factors to facilitate virus replication. Drugs targeting viral enzymes have been developed to treat HIV; the next challenge is to inhibit virus-cell interactions as next generation treatment strategies. Organized  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Retrovirus-Cell Interactions.
London, United Kingdom ; San Diego, CA, United States : Academic Press is an imprint of Elsevier, [2018]
(OCoLC)1029798804
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Leslie J Parent
ISBN: 9780128111932 0128111933
OCLC Number: 1048402942
Description: 1 online resource
Contents: The TriggersConserved Motifs in Envelope Proteins Are Critical to Regulation of Fusion; Regulation by Control of the Conformation of Surface Subunit; Regulation by Control of Disulfide Bond Isomerization and Surface Subunit Conformation; Lentiviruses: Receptor-Triggered Conformational Changes in the Surface Subunit; Gammaretroviruses: Receptor- and Cellular Protease-Driven Disulfide Bond Isomerization; Alpharetroviruses: Receptor- and Low pH-Driven Disulfide Bond Isomerization; DO ENV-RECEPTOR INTERACTIONS CONTRIBUTE TO PATHOGENESIS?; CD4+ T-Cell Depletion and AIDS Neurological Damage and HAM/TSPMutations That Adapt Virus to Low Receptor Levels Can Also Increase Pathogenicity; Envelope Protein-Driven Neoplasia in Betaretrovirus Infection; HOST DEFENSES THAT INHIBIT RETROVIRAL ENTRY ALSO DRIVE ENVELOPE PROTEIN VARIATION; Challenges in Vaccine Development; Interferon-Induced Transmembrane Proteins and Envelope Proteins Variation; COEVOLUTION OF VIRUS AND RECEPTOR; CAPTURED RETROVIRAL ENVELOPE PROTEINS IN THE DEVELOPMENT OF MAMMALIAN PLACENTA AND MALE MUSCLE MASS; REFERENCES; 2 --
Cellular Factors That Regulate Retrovirus Uncoating and Reverse Transcription
Responsibility: edited by Leslie J. Parent.

Abstract:

Retrovirus-Cell Interactions provides an up-to-date review of the interactions between retroviruses and the cells they infect, offering a comprehensive understanding of how retroviruses hijack cellular factors to facilitate virus replication. Drugs targeting viral enzymes have been developed to treat HIV; the next challenge is to inhibit virus-cell interactions as next generation treatment strategies. Organized according to the retrovirus' replication cycle, this book does not focus exclusively on HIV, but rather includes important findings in other retroviral systems, including animal retroviruses, retrotransposons, and endogenous retroelements to allow broad comparisons on important commonalities and differences. Provides a valuable starting point for people who want to develop a detailed understanding of retroviral replication Includes future-thinking strategies, such as next-generation treatment and anti-retroviral therapeutics features important commonalities and differences among retroviral systems

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