skip to content
Rho GTPases : molecular biology in health and disease Preview this item
ClosePreview this item
Checking...

Rho GTPases : molecular biology in health and disease

Author: Philippe Fort; Anne Blangy
Publisher: Singapore ; Hackensack, NJ : World Scientific Publishing Co. Pte. Ltd., [2018]
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
"Rho GTPases control many aspects of cell physiology. This includes polarity, endo/exocytosis, adhesion, motility, transcriptional activation, cell cycle progression or apoptosis. In view of such pleiotropic activities, Rho-controlled signaling has proven to be of medical relevance, especially in tumorigenesis, disease-associated bone remodeling and infectiology. This book is divided into three parts. Part 1 gives  Read more...
Rating:

(not yet rated) 0 with reviews - Be the first.

Subjects
More like this

Find a copy online

Links to this item

Find a copy in the library

&AllPage.SpinnerRetrieving; Finding libraries that hold this item...

Details

Genre/Form: Electronic books
Additional Physical Format: Print version:
Rho GTPases.
New Jersey : World Scientific, [2018]
(DLC) 2017026747
(OCoLC)989525591
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Philippe Fort; Anne Blangy
ISBN: 9789813228795 9813228792 9789813228801 9813228806
OCLC Number: 1020286113
Description: 1 online resource
Contents: Rho signaling : an historical and evolutionary perspective / Philippe Fort --
Atypical rho GTPases in health and disease / Pontus Aspenstrom --
Regulators of rho signaling / Ehsan Amin and Mohammad R. Ahmadian --
Rho GTPases in cadherin-based cell-cell interactions : adhesion, repulsion, fusion / Fernanda Bajanca, Elena Scarpa and Eric Theveneau --
Rho signaling in mechanotransduction / Elizabeth Monaghan-Benson and Christophe Guilluy --
Post-translational modifications of rho GTPases mediated by bacterial toxins and cellular systems / Emmanuel Lemichez, Amel Mettouchi and Michel Robert Popoff --
RHOA mutations in cancer : oncogenes or tumor suppressors? / Devon R. Blake and Channing J. Der --
Modulation of osteoclast differentiation and function by rho GTPases / Yongqiang Wang, Patricia Joyce Brooks and Michael Glogauer --
RhoGEFs as therapeutic targets / Anne Blangy --
Endothelial specific GTPase signaling during leukocyte extravasation / Sofia Morsing, Lilian Schimmel, Jos van Rijssel and Jaap D. van Buul.
Other Titles: Rho GTPases (Fort)
Responsibility: editors, Philippe Fort, Anne Blangy.

Abstract:

"Rho GTPases control many aspects of cell physiology. This includes polarity, endo/exocytosis, adhesion, motility, transcriptional activation, cell cycle progression or apoptosis. In view of such pleiotropic activities, Rho-controlled signaling has proven to be of medical relevance, especially in tumorigenesis, disease-associated bone remodeling and infectiology. This book is divided into three parts. Part 1 gives an evolutionary perspective of the Rho family, its atypical members, and an overview of how Rho activity is regulated. Part 2 addresses two important aspects of multicellularity controlled by Rho-dependent pathways, namely, cell-cell interactions and mechanotransduction. It also describes how post-translational modifications control Rho activity and how this is exploited by pathogenic bacteria. Part 3 explores several examples of the variety of pathophysiological processes controlled by Rho signaling, and gives a successful example of translational research, from the inhibition of Rho activation to the development of new molecules against osteoporosis. This updated review on the biology of Rho GTPases is an essential read for molecular and cell biologists. It is also an invaluable guide to post-graduate and medical students who wish to deepen their knowledge in cell biology."--

Reviews

User-contributed reviews
Retrieving GoodReads reviews...
Retrieving DOGObooks reviews...

Tags

Be the first.
Confirm this request

You may have already requested this item. Please select Ok if you would like to proceed with this request anyway.

Linked Data


Primary Entity

<http://www.worldcat.org/oclc/1020286113> # Rho GTPases : molecular biology in health and disease
    a schema:MediaObject, schema:CreativeWork, schema:Book ;
    library:oclcnum "1020286113" ;
    library:placeOfPublication <http://id.loc.gov/vocabulary/countries/si> ;
    schema:about <http://experiment.worldcat.org/entity/work/data/4417715736#Topic/rho_gtp_binding_proteins> ; # rho GTP-Binding Proteins
    schema:about <http://dewey.info/class/572.633/e23/> ;
    schema:about <http://experiment.worldcat.org/entity/work/data/4417715736#Topic/cellular_signal_transduction> ; # Cellular signal transduction
    schema:about <http://experiment.worldcat.org/entity/work/data/4417715736#Topic/rho_gtpases> ; # Rho GTPases
    schema:about <http://experiment.worldcat.org/entity/work/data/4417715736#Topic/signal_transduction> ; # Signal Transduction
    schema:about <http://experiment.worldcat.org/entity/work/data/4417715736#Topic/science_life_sciences_biochemistry> ; # SCIENCE--Life Sciences--Biochemistry
    schema:about <http://experiment.worldcat.org/entity/work/data/4417715736#Topic/carrier_proteins> ; # Carrier proteins
    schema:bookFormat schema:EBook ;
    schema:datePublished "2018" ;
    schema:description ""Rho GTPases control many aspects of cell physiology. This includes polarity, endo/exocytosis, adhesion, motility, transcriptional activation, cell cycle progression or apoptosis. In view of such pleiotropic activities, Rho-controlled signaling has proven to be of medical relevance, especially in tumorigenesis, disease-associated bone remodeling and infectiology. This book is divided into three parts. Part 1 gives an evolutionary perspective of the Rho family, its atypical members, and an overview of how Rho activity is regulated. Part 2 addresses two important aspects of multicellularity controlled by Rho-dependent pathways, namely, cell-cell interactions and mechanotransduction. It also describes how post-translational modifications control Rho activity and how this is exploited by pathogenic bacteria. Part 3 explores several examples of the variety of pathophysiological processes controlled by Rho signaling, and gives a successful example of translational research, from the inhibition of Rho activation to the development of new molecules against osteoporosis. This updated review on the biology of Rho GTPases is an essential read for molecular and cell biologists. It is also an invaluable guide to post-graduate and medical students who wish to deepen their knowledge in cell biology."--"@en ;
    schema:description "Rho signaling : an historical and evolutionary perspective / Philippe Fort -- Atypical rho GTPases in health and disease / Pontus Aspenstrom -- Regulators of rho signaling / Ehsan Amin and Mohammad R. Ahmadian -- Rho GTPases in cadherin-based cell-cell interactions : adhesion, repulsion, fusion / Fernanda Bajanca, Elena Scarpa and Eric Theveneau -- Rho signaling in mechanotransduction / Elizabeth Monaghan-Benson and Christophe Guilluy -- Post-translational modifications of rho GTPases mediated by bacterial toxins and cellular systems / Emmanuel Lemichez, Amel Mettouchi and Michel Robert Popoff -- RHOA mutations in cancer : oncogenes or tumor suppressors? / Devon R. Blake and Channing J. Der -- Modulation of osteoclast differentiation and function by rho GTPases / Yongqiang Wang, Patricia Joyce Brooks and Michael Glogauer -- RhoGEFs as therapeutic targets / Anne Blangy -- Endothelial specific GTPase signaling during leukocyte extravasation / Sofia Morsing, Lilian Schimmel, Jos van Rijssel and Jaap D. van Buul."@en ;
    schema:editor <http://experiment.worldcat.org/entity/work/data/4417715736#Person/fort_philippe> ; # Philippe Fort
    schema:editor <http://experiment.worldcat.org/entity/work/data/4417715736#Person/blangy_anne> ; # Anne Blangy
    schema:exampleOfWork <http://worldcat.org/entity/work/id/4417715736> ; # Rho GTPases (Fort)
    schema:genre "Electronic books"@en ;
    schema:inLanguage "en" ;
    schema:isSimilarTo <http://www.worldcat.org/oclc/989525591> ;
    schema:name "Rho GTPases : molecular biology in health and disease"@en ;
    schema:productID "1020286113" ;
    schema:url <http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=1691423> ;
    schema:url <http://www.worldscientific.com/worldscibooks/10.1142/10674#t=toc> ;
    schema:url <http://public.eblib.com/choice/publicfullrecord.aspx?p=5233569> ;
    schema:url <http://www.vlebooks.com/vleweb/product/openreader?id=none&isbn=9789813228795> ;
    schema:workExample <http://worldcat.org/isbn/9789813228801> ;
    schema:workExample <http://worldcat.org/isbn/9789813228795> ;
    wdrs:describedby <http://www.worldcat.org/title/-/oclc/1020286113> ;
    .


Related Entities

<http://experiment.worldcat.org/entity/work/data/4417715736#Person/blangy_anne> # Anne Blangy
    a schema:Person ;
    schema:familyName "Blangy" ;
    schema:givenName "Anne" ;
    schema:name "Anne Blangy" ;
    .

<http://experiment.worldcat.org/entity/work/data/4417715736#Person/fort_philippe> # Philippe Fort
    a schema:Person ;
    schema:familyName "Fort" ;
    schema:givenName "Philippe" ;
    schema:name "Philippe Fort" ;
    .

<http://experiment.worldcat.org/entity/work/data/4417715736#Topic/cellular_signal_transduction> # Cellular signal transduction
    a schema:Intangible ;
    schema:name "Cellular signal transduction"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/4417715736#Topic/rho_gtp_binding_proteins> # rho GTP-Binding Proteins
    a schema:Intangible ;
    schema:name "rho GTP-Binding Proteins"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/4417715736#Topic/science_life_sciences_biochemistry> # SCIENCE--Life Sciences--Biochemistry
    a schema:Intangible ;
    schema:name "SCIENCE--Life Sciences--Biochemistry"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/4417715736#Topic/signal_transduction> # Signal Transduction
    a schema:Intangible ;
    schema:name "Signal Transduction"@en ;
    .

<http://worldcat.org/entity/work/id/4417715736> # Rho GTPases (Fort)
    schema:name "Rho GTPases (Fort)"@en ;
    .

<http://worldcat.org/isbn/9789813228795>
    a schema:ProductModel ;
    schema:isbn "9813228792" ;
    schema:isbn "9789813228795" ;
    .

<http://worldcat.org/isbn/9789813228801>
    a schema:ProductModel ;
    schema:isbn "9813228806" ;
    schema:isbn "9789813228801" ;
    .

<http://www.worldcat.org/oclc/989525591>
    a schema:CreativeWork ;
    rdfs:label "Rho GTPases." ;
    schema:description "Print version:" ;
    schema:isSimilarTo <http://www.worldcat.org/oclc/1020286113> ; # Rho GTPases : molecular biology in health and disease
    .


Content-negotiable representations

Close Window

Please sign in to WorldCat 

Don't have an account? You can easily create a free account.