The role of IL-1beta, IL-6, and TNF-alpha in radiation-induced bone loss. (Computer file, 2010) [WorldCat.org]
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The role of IL-1β, IL-6, and TNFα in radiation-induced bone loss /
The role of IL-1beta, IL-6, and TNF-alpha in radiation-induced bone loss.

Author: by Stephanie Erin Riffle. ; Stephanie Erin Riffle
Publisher: 2010.
Dissertation: M.S. Clemson University 2010
Edition/Format:   Computer file : Document : Thesis/dissertation : English
Summary:
Abstract: Bone fractures greatly decrease an individual's quality of life, as well as increase an individual's risk for further complications, including death. Ionizing radiation causes bone loss, leaving bones at increased risk of fracture. This exposure, particularly in the context of cancer patients receiving radiotherapy, results in damage to normal (non-tumor) tissue. Inflammation is a common response to  Read more...
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Details

Genre/Form: Academic theses
Material Type: Document, Thesis/dissertation, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: by Stephanie Erin Riffle. ; Stephanie Erin Riffle
OCLC Number: 671940960
Notes: Title from first page of PDF file.
Document formatted into pages; contains xiii, 83 p. ; also includes graphics.
Description: 1 online resource
Details: System requirements: World Wide Web browser and PDF viewer.
More information:

Abstract:

Abstract: Bone fractures greatly decrease an individual's quality of life, as well as increase an individual's risk for further complications, including death. Ionizing radiation causes bone loss, leaving bones at increased risk of fracture. This exposure, particularly in the context of cancer patients receiving radiotherapy, results in damage to normal (non-tumor) tissue. Inflammation is a common response to radiation-induced tissue damage, characterized by increased presence of pro-inflammatory cytokines, such as IL-1beta, IL-6, and TNF-alpha. However, little is known about the roles of these cytokines in radiation-induced bone loss. This thesis hypothesized that the up regulation of pro-inflammatory cytokines (IL-1beta, IL-6, and TNF-alpha) after irradiation would lead to rapid activation of osteoclasts and subsequent bone loss. Three approaches were used to investigate the roles of these cytokines in radiation-induced bone loss: 1) Rodent models deficient in IL-1beta receptor, IL-6, TNF-alpha, and TNF-alpha/IL-1beta receptor combined; 2) Administration of TNF-binding protein (Enbrel), IL-1 receptor antagonist (Kineret), or a combination of the two; 3) Administration of a p38 blocking molecule (AR-447). Irradiation did result in a decline of bone volume and overall deterioration of micro-architecture within the first few weeks after exposure. Additionally, pro-inflammatory cytokine presence and expression were elevated at early time points after exposure. However, using IL-1beta, IL-6, and TNF-alpha knockout mouse strains or applying agents that block the activity of these cytokines did not prevent bone loss after radiation exposure. Providing an inhibitor of p38 activity, an important upstream and downstream mediator of pro-inflammatory cytokine production, likewise did not prevent radiation-induced osteoporosis. Therefore, within the confines of these animal studies, pro-inflammatory cytokines did not play a significant role, if any role at all, in radiation-induced bone loss, suggesting the possibility that these cytokines are not responsible for the radiation-induced activation of osteoclasts.

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