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The Role of pharmacology in pediatric oncology

Author: David G Poplack; Luisa Massimo; Paolo Cornaglia Ferraris
Publisher: Dordrecht ; Boston : Nijhoff ; Hingham, MA, USA : Distributors for the U.S. and Canada, Kluwer Academic Publishers, ©1987.
Series: Developments in oncology.
Edition/Format:   Print book : EnglishView all editions and formats
Summary:

In this book basic principles of pharmacology, mechanisms of drug resis- tance, new methods of drug delivery, guidelines for studying new agents in children, new biological response modifiers and the  Read more...

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Genre/Form: Congress
Additional Physical Format: Online version:
Role of pharmacology in pediatric oncology.
Dordrecht ; Boston : Nijhoff ; Hingham, MA, USA : Distributors for the U.S. and Canada, Kluwer Academic Publishers, ©1987
(OCoLC)572387380
Document Type: Book
All Authors / Contributors: David G Poplack; Luisa Massimo; Paolo Cornaglia Ferraris
ISBN: 0898387957 9780898387957 9789401083959 9401083959 9789400942677 9400942672
OCLC Number: 13093414
Description: xii, 322 pages : illustrations ; 25 cm.
Contents: Principles of Antineoplastic Therapy in Children.- 1. Clinical pharmacokinetics for the pediatric oncologist.- 2. The pharmacology of antineoplastic agents in children.- 3. Clinical pharmacology of anticancer drugs in children: differences and similarities between children and adults.- Pharmacologic reasons for treatment failure.- 4. Drug resistance in medical and pediatric oncology.- 5. Genetic reasons for pharmacologic treatment failure: gene amplification.- 6. New approaches to overcome drug resistance.- Methods of drug delivery.- 7. New methods of administering old drugs: iv infusion of mercaptopurine.- 8. Regional therapy: an overview.- 9. Pharmacologic approaches to the treatment of central nervous system malignancy.- Use of new agents in children.- 10. Phase I and II trials in pediatric cancer patients: a rationale.- 11. Guidelines for conduct of Phase I studies in children.- Pharmacology of antileukemic agents.- 12. Factors affecting the clinical pharmacology of antileukemic drugs.- 13. Potentiation of 6-mercaptopurine after time and dose-dependent pretreatment with methotrexate in malignant human T- and B-lymphoblasts.- 14. The effect of methotrexate on purine and pyrimidine deoxyribonucleoside triphosphate pools and on cell viability and cell-phase distribution in malignant human T- and B-lymphoblasts.- 15. 7-Hydroxy-methotrexate production after methotrexate therapy.- Late effects of chemotherapy.- 16. An overview of adverse late effects of cancer chemotherapy in children.- 17. Focusing on late effects in long-term survivors of childhood leukemia and lymphomas.- High dose chemotherapy.- 18. Purging procedures: a critical step in autologous bone marrow transplantation.- 19. `High dose' cisplatinum: a phase II study.- Biological response modifiers.- 20. Induction of differentiation: a possible therapeutic approach to the treatment of hematologic malignancy.- 21. The development of 9-substituted purines as immunomodulators.- 22. Immunopharmacologic profile of an L-Arginine hypoxanthine dervative: PCF/01.- 23. Antineoplastic drugs modulating c-myc expression in K562, induce erythroid differentiation and modify, with IFN, susceptibility to NK cell mediated lysis.- 24. In vivo treatment with recombinant interleukin-2 (IL-2) stimulates the differentiation of natural killer (NK) precursor cells.- 25. Immunopharmacology studies related to in vitro infection with HTLV-I.
Series Title: Developments in oncology.
Responsibility: edited by D.G. Poplack, L. Massimo, P. Cornaglia-Ferraris.

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Primary Entity<\/h3>\n
<http:\/\/www.worldcat.org\/oclc\/13093414<\/a>> # The Role of pharmacology in pediatric oncology<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Book<\/a>, schema:CreativeWork<\/a> ;\u00A0\u00A0\u00A0\nlibrary:oclcnum<\/a> \"13093414<\/span>\" ;\u00A0\u00A0\u00A0\nlibrary:placeOfPublication<\/a> <http:\/\/dbpedia.org\/resource\/Boston<\/a>> ; # Boston<\/span>\n\u00A0\u00A0\u00A0\nlibrary:placeOfPublication<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/356075745#Place\/dordrecht<\/a>> ; # Dordrecht<\/span>\n\u00A0\u00A0\u00A0\nlibrary:placeOfPublication<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/356075745#Place\/hingham_ma_usa<\/a>> ; # Hingham, MA, USA<\/span>\n\u00A0\u00A0\u00A0\nlibrary:placeOfPublication<\/a> <http:\/\/id.loc.gov\/vocabulary\/countries\/ne<\/a>> ;\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/356075745#Topic\/neoplasms<\/a>> ; # Neoplasms<\/span>\n\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/356075745#Topic\/pediatric_pharmacology<\/a>> ; # Pediatric pharmacology<\/span>\n\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/356075745#Topic\/tumors_in_children_chemotherapy<\/a>> ; # Tumors in children--Chemotherapy<\/span>\n\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/356075745#Topic\/aufsatzsammlung<\/a>> ; # Aufsatzsammlung<\/span>\n\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/356075745#Topic\/child<\/a>> ; # Child<\/span>\n\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/dewey.info\/class\/618.92992061\/e19\/<\/a>> ;\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/356075745#Topic\/kind<\/a>> ; # Kind<\/span>\n\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/356075745#Topic\/infant<\/a>> ; # Infant<\/span>\n\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/356075745#Topic\/pharmakotherapie<\/a>> ; # Pharmakotherapie<\/span>\n\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/356075745#Topic\/neoplasms_drug_therapy<\/a>> ; # Neoplasms--drug therapy<\/span>\n\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/356075745#Topic\/krebs<\/a>> ; # Krebs<\/span>\n\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/356075745#Thing\/children<\/a>> ; # Children<\/span>\n\u00A0\u00A0\u00A0\nschema:bookFormat<\/a> bgn:PrintBook<\/a> ;\u00A0\u00A0\u00A0\nschema:contributor<\/a> <http:\/\/viaf.org\/viaf\/28534814<\/a>> ; # Luisa Massimo<\/span>\n\u00A0\u00A0\u00A0\nschema:contributor<\/a> <http:\/\/viaf.org\/viaf\/94946735<\/a>> ; # David G. Poplack<\/span>\n\u00A0\u00A0\u00A0\nschema:contributor<\/a> <http:\/\/viaf.org\/viaf\/21144276<\/a>> ; # Paolo Cornaglia Ferraris<\/span>\n\u00A0\u00A0\u00A0\nschema:copyrightYear<\/a> \"1987<\/span>\" ;\u00A0\u00A0\u00A0\nschema:datePublished<\/a> \"1987<\/span>\" ;\u00A0\u00A0\u00A0\nschema:exampleOfWork<\/a> <http:\/\/worldcat.org\/entity\/work\/id\/356075745<\/a>> ;\u00A0\u00A0\u00A0\nschema:genre<\/a> \"Congress<\/span>\"@en<\/a> ;\u00A0\u00A0\u00A0\nschema:inLanguage<\/a> \"en<\/span>\" ;\u00A0\u00A0\u00A0\nschema:isPartOf<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/356075745#Series\/developments_in_oncology<\/a>> ; # Developments in oncology.<\/span>\n\u00A0\u00A0\u00A0\nschema:isSimilarTo<\/a> <http:\/\/www.worldcat.org\/oclc\/572387380<\/a>> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"The Role of pharmacology in pediatric oncology<\/span>\"@en<\/a> ;\u00A0\u00A0\u00A0\nschema:productID<\/a> \"13093414<\/span>\" ;\u00A0\u00A0\u00A0\nschema:publication<\/a> <http:\/\/www.worldcat.org\/title\/-\/oclc\/13093414#PublicationEvent\/dordrecht_boston_nijhoff_hingham_ma_usa_distributors_for_the_u_s_and_canada_kluwer_academic_publishers_1987<\/a>> ;\u00A0\u00A0\u00A0\nschema:publisher<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/356075745#Agent\/distributors_for_the_u_s_and_canada_kluwer_academic_publishers<\/a>> ; # Distributors for the U.S. and Canada, Kluwer Academic Publishers<\/span>\n\u00A0\u00A0\u00A0\nschema:publisher<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/356075745#Agent\/nijhoff<\/a>> ; # Nijhoff<\/span>\n\u00A0\u00A0\u00A0\nschema:workExample<\/a> <http:\/\/worldcat.org\/isbn\/9780898387957<\/a>> ;\u00A0\u00A0\u00A0\nschema:workExample<\/a> <http:\/\/worldcat.org\/isbn\/9789400942677<\/a>> ;\u00A0\u00A0\u00A0\nschema:workExample<\/a> <http:\/\/worldcat.org\/isbn\/9789401083959<\/a>> ;\u00A0\u00A0\u00A0\numbel:isLike<\/a> <http:\/\/bnb.data.bl.uk\/id\/resource\/GB8730218<\/a>> ;\u00A0\u00A0\u00A0\nwdrs:describedby<\/a> <http:\/\/www.worldcat.org\/title\/-\/oclc\/13093414<\/a>> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n\n

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<http:\/\/dewey.info\/class\/618.92992061\/e19\/<\/a>>\u00A0\u00A0\u00A0\u00A0a \nschema:Intangible<\/a> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/356075745#Agent\/distributors_for_the_u_s_and_canada_kluwer_academic_publishers<\/a>> # Distributors for the U.S. and Canada, Kluwer Academic Publishers<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nbgn:Agent<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Distributors for the U.S. and Canada, Kluwer Academic Publishers<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/356075745#Agent\/nijhoff<\/a>> # Nijhoff<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nbgn:Agent<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Nijhoff<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/356075745#Place\/dordrecht<\/a>> # Dordrecht<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Place<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Dordrecht<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/356075745#Place\/hingham_ma_usa<\/a>> # Hingham, MA, USA<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Place<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Hingham, MA, USA<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/356075745#Series\/developments_in_oncology<\/a>> # Developments in oncology.<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nbgn:PublicationSeries<\/a> ;\u00A0\u00A0\u00A0\nschema:hasPart<\/a> <http:\/\/www.worldcat.org\/oclc\/13093414<\/a>> ; # The Role of pharmacology in pediatric oncology<\/span>\n\u00A0\u00A0\u00A0\nschema:name<\/a> \"Developments in oncology.<\/span>\" ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Developments in oncology<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/356075745#Thing\/children<\/a>> # Children<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Thing<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Children<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/356075745#Topic\/aufsatzsammlung<\/a>> # Aufsatzsammlung<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Intangible<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Aufsatzsammlung<\/span>\"@en<\/a> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/356075745#Topic\/child<\/a>> # Child<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Intangible<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Child<\/span>\"@en<\/a> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/356075745#Topic\/infant<\/a>> # Infant<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Intangible<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Infant<\/span>\"@en<\/a> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/356075745#Topic\/kind<\/a>> # Kind<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Intangible<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Kind<\/span>\"@en<\/a> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/356075745#Topic\/krebs<\/a>> # Krebs<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Intangible<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Krebs<\/span>\"@en<\/a> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
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<http:\/\/experiment.worldcat.org\/entity\/work\/data\/356075745#Topic\/neoplasms_drug_therapy<\/a>> # Neoplasms--drug therapy<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Intangible<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Neoplasms--drug therapy<\/span>\"@en<\/a> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/356075745#Topic\/pediatric_pharmacology<\/a>> # Pediatric pharmacology<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Intangible<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Pediatric pharmacology<\/span>\"@en<\/a> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/356075745#Topic\/pharmakotherapie<\/a>> # Pharmakotherapie<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Intangible<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Pharmakotherapie<\/span>\"@en<\/a> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/356075745#Topic\/tumors_in_children_chemotherapy<\/a>> # Tumors in children--Chemotherapy<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Intangible<\/a> ;\u00A0\u00A0\u00A0\nschema:hasPart<\/a> <http:\/\/id.loc.gov\/authorities\/subjects\/sh85138568<\/a>> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Tumors in children--Chemotherapy<\/span>\"@en<\/a> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
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<http:\/\/viaf.org\/viaf\/21144276<\/a>> # Paolo Cornaglia Ferraris<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Person<\/a> ;\u00A0\u00A0\u00A0\nschema:familyName<\/a> \"Cornaglia Ferraris<\/span>\" ;\u00A0\u00A0\u00A0\nschema:givenName<\/a> \"Paolo<\/span>\" ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Paolo Cornaglia Ferraris<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/viaf.org\/viaf\/28534814<\/a>> # Luisa Massimo<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Person<\/a> ;\u00A0\u00A0\u00A0\nschema:familyName<\/a> \"Massimo<\/span>\" ;\u00A0\u00A0\u00A0\nschema:givenName<\/a> \"Luisa<\/span>\" ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Luisa Massimo<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/viaf.org\/viaf\/94946735<\/a>> # David G. Poplack<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Person<\/a> ;\u00A0\u00A0\u00A0\nschema:familyName<\/a> \"Poplack<\/span>\" ;\u00A0\u00A0\u00A0\nschema:givenName<\/a> \"David G.<\/span>\" ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"David G. Poplack<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
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<http:\/\/www.worldcat.org\/oclc\/572387380<\/a>>\u00A0\u00A0\u00A0\u00A0a \nschema:CreativeWork<\/a> ;\u00A0\u00A0\u00A0\nrdfs:label<\/a> \"Role of pharmacology in pediatric oncology.<\/span>\" ;\u00A0\u00A0\u00A0\nschema:description<\/a> \"Online version:<\/span>\" ;\u00A0\u00A0\u00A0\nschema:isSimilarTo<\/a> <http:\/\/www.worldcat.org\/oclc\/13093414<\/a>> ; # The Role of pharmacology in pediatric oncology<\/span>\n\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/www.worldcat.org\/title\/-\/oclc\/13093414<\/a>>\u00A0\u00A0\u00A0\u00A0a \ngenont:InformationResource<\/a>, genont:ContentTypeGenericResource<\/a> ;\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/www.worldcat.org\/oclc\/13093414<\/a>> ; # The Role of pharmacology in pediatric oncology<\/span>\n\u00A0\u00A0\u00A0\nschema:dateModified<\/a> \"2019-09-10<\/span>\" ;\u00A0\u00A0\u00A0\nvoid:inDataset<\/a> <http:\/\/purl.oclc.org\/dataset\/WorldCat<\/a>> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/www.worldcat.org\/title\/-\/oclc\/13093414#PublicationEvent\/dordrecht_boston_nijhoff_hingham_ma_usa_distributors_for_the_u_s_and_canada_kluwer_academic_publishers_1987<\/a>>\u00A0\u00A0\u00A0\u00A0a \nschema:PublicationEvent<\/a> ;\u00A0\u00A0\u00A0\nschema:location<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/356075745#Place\/hingham_ma_usa<\/a>> ; # Hingham, MA, USA<\/span>\n\u00A0\u00A0\u00A0\nschema:location<\/a> <http:\/\/dbpedia.org\/resource\/Boston<\/a>> ; # Boston<\/span>\n\u00A0\u00A0\u00A0\nschema:location<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/356075745#Place\/dordrecht<\/a>> ; # Dordrecht<\/span>\n\u00A0\u00A0\u00A0\nschema:organizer<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/356075745#Agent\/distributors_for_the_u_s_and_canada_kluwer_academic_publishers<\/a>> ; # Distributors for the U.S. and Canada, Kluwer Academic Publishers<\/span>\n\u00A0\u00A0\u00A0\nschema:organizer<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/356075745#Agent\/nijhoff<\/a>> ; # Nijhoff<\/span>\n\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n\n

Content-negotiable representations<\/p>\n