Scalable green chemistry : case studies from the pharmaceutical industry (Book, 2013) []
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Scalable green chemistry : case studies from the pharmaceutical industry

Scalable green chemistry : case studies from the pharmaceutical industry

Author: Stefan G Koenig
Publisher: Singapore : Pan Stanford Publishing, [2013].
Edition/Format:   Print book : EnglishView all editions and formats

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Document Type: Book
All Authors / Contributors: Stefan G Koenig
ISBN: 9789814316491 9814316490
OCLC Number: 881293958
Description: 1 vol. (xvii-368 p.) : ill. ; 24 cm.
Contents: Introduction to Green Pharmaceutical Science: Fact, Fiction, and Future, Julie B. ManleyGreen Chemistry in Drug Development, Apurba Bhattacharya, Siddhartha Akasapu, and Rakeshwar BandichhorIntroductionAprepitantParoxetine Pregabalin Sertraline Conclusions Development of Green-by-Design, Practical Biocatalytic Processes, Gjalt W. Huisman and Steven J. CollierIntroduction Introduction on Biocatalysis and Directed Evolution Biocatalysis and Green ChemistryKetoreductase Processes for Chiral Alcohols Transaminase Processes to Chiral Primary Amines Acyltransferase Approach to Simvastatin Integrated Biocatalytic Processes Conclusions and Outlook Application of Green Metrics to Scalable Industrial Synthesis Plans: Approaches to Oseltamivir Phosphate (Tamiflu R _), John AndraosIntroduction Green Metrics Essentials for Industrial Chemists Oseltamivir Approaches: Synthesis StrategiesOseltamivir Syntheses: Material Efficiencies Concluding Remarks The Road to Becoming Green: Process Development of AR-A2, an Active Pharmaceutical Ingredient with Antidepressant Activity, Hans-Jurgen Federsel, Martin Hedberg, Fredrik R. Qvarnstrom, and Wei TianThe Green Agenda Starting the New Project Time for Change: The Road Map to Better Synthesis Homing in on Safety, Health, and Environment (SHE) Improvements Focusing the Morpholinobenzoic Acid Side Chain: Design of the Ultimate Process Reaching the End Product: SHE Perspective on the Final Stages Summary: Improvements in Environmental Impact of the AR-A2 x HBr Process Improved and Greener Process for Pioglitazone and Its Pharmaceutically Acceptable Salts, Apurba Bhattacharya, Rakeshwar Bandichhor, and Lokeswara Rao MadivadaIntroduction A Green Attitude Synthesis of Pioglitazone Development of a Greener Process: Improved Process for Pioglitazone Process Optimization Conclusions The Development of a Convergent Green Synthesis of Linezolid, an Oxazolidinone Antibacterial Agent, William R. Perrault, James B. Keeler, William C. Snyder, Christian L. Clark, Michael R. Reeder, Richard J. Imbordino, Rebecca M. Anderson, Nabil Ghazal, Stephen L. Secreast, and Bruce A. PearlmanBackground Green Linezolid Process Conclusion Development of a Nonaqueous Process for the Synthesis of 3-Amino-pentan-1,5-diol, Thimma Rawalpally and Thomas ClearyIntroduction IND Synthesis First-Generation Aminodiol Synthesis Second-Generation Synthesis Environmental Assessment of the Synthetic Routes Development of a Robust, Environmentally Responsible Process for the Manufacture of Tofacitinib Citrate, Rajappa VaidyanathanIntroductionRetrosynthetic StrategyApproaches to Piperidine 6Choice and Synthesis of the Coupling PartnerThe Debenzylation StepAmidation, Salt Formation, and IsolationConclusionsSelective Nitration under cGMP Conditions, Peter Poechlauer, Sascha Braune, and Roland ObermullerIntroduction: Pharmaceuticals-Successful Products, Inefficient Manufacture?Pharmaceutical Production Process Intensification Process Intensification in Practice Safety First: A thorough Analysis Consequences for Plant Design Quality Continuous Improvement and Its Consequences on the Environmental Impact of a Plant Conclusion Going Green Using Combined Real-Time Analytics and Process Automation, Dominique Hebrault and Terry RedmanIntroduction Case Studies General Conclusions Approaches to the Scale-Up of Organic Chemistry Using Microwave Heating, Nicholas E. LeadbeaterIntroduction Scale-Up of Chemistry Performed Using Microwave Heating Concluding Remarks Challenges Faced and Future Directions, Stefan G. KoenigIntroduction Successful Beginnings The Future of Green Chemistry Conclusions Index 357
Responsibility: edited by Stefan G. Koenig.


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"At last! A book which provides a discussion of green chemistry from a process chemistry/engineering viewpoint. The case studies on individual pharmaceuticals in the various chapters are supplemented Read more...

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