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Solid-Phase Synthesis : a Practical Guide

Author: Fernando Albericio
Publisher: Boca Raton, FL : CRC Press, 2000.
Edition/Format:   eBook : Document : English : First editionView all editions and formats
Summary:
"This volume provides the information needed to synthesize peptides by solid-phase synthesis (SPS) - employing polymeric support (resins), anchoring linkages (handles), coupling reagents (activators), and protection schemes. It presents strategies for creating a wide variety of compounds for drug discovery and analyzes peptides, DNA, carbohydrates, conjugates of biomolecules, and small molecules."--Provided by  Read more...
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Genre/Form: Electronic books
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Fernando Albericio
ISBN: 9781482270303 1482270307
OCLC Number: 1027779097
Description: 1 online resource : text file, PDF
Contents: Cover; Half Title; Title Page; Copyright Page; Foreword; Preface; Contents; Contributors; Introduction: The Impact of Genome Sequencing on Drug Discovery; I. IDENTIFICATION OF DRUG TARGETS; II. GENE MICROARRAYS FOR GLOBAL EFFECTSOF DRUGS; III. HIGH-THROUGHPUT SCREENS AT THECELLULAR LEVEL; IV. PREDICTION OF PROTEIN STRUCTURE AND FUNCTION; V. DESIGN OF COMBINATORIAL LIBRARIES FOR MEMBERS OF PROTEIN FAMILIES; 1: The Solid Support; I. INTRODUCTION; II. POLYSTYRENE RESINS; A. Low Cross-Linked Polystyrene; B. High Cross-Linked Polystyrene; C. Polystyrene Grafted onto Polyethylene Film or Tubing III. POLYETHYLENE GLYCOL RESINSA. Polyethylene Glycol Grafted Resins; B. Polyethylene Glycol-Based Resins; IV. CONTROLLED PORE GLASS AND OTHER SILICA-BASED SUPPORTS; A. Controlled Pore Glass (CPG); B. Silica Gels; V. MEMBRANES; A. Cellulose; B. Organic Membranes; VI. MISCELLANEOUS; A. Polyacrylamide Bead Gels; B. Polyacrylamide-Supported Gel; C. Multipin Supports; D. ASPECTS; E. Chitin Support; F. Sepharose and LH-20; G. Beaded Cellulose; H. Protein Precipitates; VII. ANALYTICAL METHODS; A. Amino Acid Analysis; B. Elemental Analysis; C. Color Tests; D. Fmoc Monitoring; E. Picric Acid F. Modified Volhard MethodG. Infrared Spectroscopy; ACKNOWLEDGMENTS; REFERENCES; 2: Strategy in Solid-Phase Peptide Synthesis; I. INTRODUCTION; II. STEPWISE SPPS; A. Solid Supports; B. Anchoring; C. Protection Schemes; D. Coupling Chemistries; E. Analysis; III. CONVERGENT SYNTHESIS; A. Solid-Phase Protected Segment Condensations; B. Chemical Ligations; IV. CONCLUSION; REFERENCES; 3: Amino Acids: Alpha-Amino Protecting Groups; I. INTRODUCTION; II. ACID-LABILE GROUPS; A. tert-Butyloxycarbonyl (Boc); B. 2-(4-Biphenylyl)-isopropoxycarbonyl (Bpoc); III. BASE-LABILE GROUPS A. 9-Fluorenylmethoxycarbonyl (Fmoc)IV. OTHER PROTECTING GROUPS; A. Thiol Labile Groups; B. Photolabile Groups; C. Other; V. ANALYTICAL METHODS; A. Thin-Layer Chromatography (TLC); B. TLC Identification Sprays; C. High-Performance Liquid Chromatography (HPLC); D. Elemental Analysis, Optical Rotation, Melting Point; E. Other; ACKNOWLEDGMENTS; APPENDIX; REFERENCES; 4: Side-Chain Protecting Groups; I. INTRODUCTION; II. ASPARTIC AND GLUTAMIC ACIDS; III. ASPARAGINE AND GLUTAMINE; IV. SERINE, THREONINE, AND HYDROXYPROLINE; V. CYSTEINE; VI. METHIONINE; VII. TYROSINE; VIII. HISTIDINE; IX. TRYPTOPHAN X. LYSINE AND ORNITHINEXI. ARGININE; XII. BACKBONE AMIDE PROTECTION; XIII. ANALYTICAL METHODS; XIV. SELECTED PROCEDURES; A. Aspartic and Glutamic Acid; B. Asparagine: L-Asn(Trt)-OH. O.5 H20 [41]; C. Serine and Threonine; D. Tyrosine: N-(9-Fluorenylmethoxycarbonyl)-O-tertbutyl-L-tyrosine [61]; E. Histidine: Nim_Tritylhistidine [132]; F. Lysine: Ne-Allyloxycarbonyl-L-Iysine Hydrochloride [167]; G. Arginine: NW-2,2,5,7,8-Pentamethylchroman-6-sulfonyl-L-arginine [181]; ADDITIONAL SOURCE FOR RESEARCH; REFERENCES; Appendix A Side-Chain Protecting Groups; Appendix B Amide Backbone Protecting Groups
Responsibility: editor, Fernando Albericio.

Abstract:

"This volume provides the information needed to synthesize peptides by solid-phase synthesis (SPS) - employing polymeric support (resins), anchoring linkages (handles), coupling reagents (activators), and protection schemes. It presents strategies for creating a wide variety of compounds for drug discovery and analyzes peptides, DNA, carbohydrates, conjugates of biomolecules, and small molecules."--Provided by publisher.

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