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Steady antibiotic release from biodegradable beads in the pleural cavity: an in vitro and in vivo study.
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Steady antibiotic release from biodegradable beads in the pleural cavity: an in vitro and in vivo study.

Author: KS Liu Affiliation: Department of Mechanical Engineering, Chang Gung University, Tao-Yuan; Department of Thoracic and Cardiovascular Surgery, Chang Gung Memorial Hospital, Linkou.SJ Liu Affiliation: Department of Mechanical Engineering, Chang Gung University, Tao-Yuan. Electronic address: shihjung@mail.cgu.edu.tw.HY Chen Affiliation: Department of Mechanical Engineering, Chang Gung University, Tao-Yuan.YK Huang Affiliation: Department of Thoracic and Cardiovascular Surgery, Chang Gung Memorial Hospital, Linkou.YJ Peng Affiliation: Department of Ophthalmology, Buddhist Tzu Chi General Hospital, Taipei Branch, Taipei, Taiwan.All authors
Edition/Format: Article Article : English
Publication:Chest, 2012 May; 141(5): 1197-1202
Other Databases: WorldCatWorldCat
Summary:
BACKGROUND: Inadequate localized drug concentrations and systemic adverse effects are among the concerns when regional infections are treated with systemic antibiotics. We designed and fabricated a poly(D,L)-lactide-co-glycolide (PLGA)-based biodegradable drug delivery system and evaluated the release of antibiotics both in vitro and in vivo. METHODS: PLGA copolymer and penicillin G sodium were mixed, compressed,  Read more...
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Document Type: Article
All Authors / Contributors: KS Liu Affiliation: Department of Mechanical Engineering, Chang Gung University, Tao-Yuan; Department of Thoracic and Cardiovascular Surgery, Chang Gung Memorial Hospital, Linkou.; SJ Liu Affiliation: Department of Mechanical Engineering, Chang Gung University, Tao-Yuan. Electronic address: shihjung@mail.cgu.edu.tw.; HY Chen Affiliation: Department of Mechanical Engineering, Chang Gung University, Tao-Yuan.; YK Huang Affiliation: Department of Thoracic and Cardiovascular Surgery, Chang Gung Memorial Hospital, Linkou.; YJ Peng Affiliation: Department of Ophthalmology, Buddhist Tzu Chi General Hospital, Taipei Branch, Taipei, Taiwan.; RC Wu Affiliation: Department of Pathology, Chang Gung Memorial Hospital, Linkou.; SW Ueng Affiliation: Department of Orthopedic Surgery, Chang Gung Memorial Hospital, Linkou.
ISSN:0012-3692
Language Note: English
Unique Identifier: 793118676
Awards:

Abstract:

BACKGROUND: Inadequate localized drug concentrations and systemic adverse effects are among the concerns when regional infections are treated with systemic antibiotics. We designed and fabricated a poly(D,L)-lactide-co-glycolide (PLGA)-based biodegradable drug delivery system and evaluated the release of antibiotics both in vitro and in vivo. METHODS: PLGA copolymer and penicillin G sodium were mixed, compressed, and sintered to fabricate biodegradable antibiotic beads. The beads were placed in phosphate-buffered saline to test the characteristics of in vitro drug release. The beads then were introduced into the pleural cavities through chest tubes of six New Zealand white rabbits. Daily pleural effusion was collected to measure the antibiotic concentration and bacterial inhibitory characteristics. RESULTS: Forty percent of the penicillin was released in the first day in the in vitro study. The rest of the antibiotic was then gradually released in the following 30 days. All six animals survived the experiment. The initial surge of drug release was less significant in the pleural cavity than in the phosphate-buffered saline. The drug concentrations were well above the minimum inhibitory concentration breakpoint for penicillin susceptibility throughout the study period in both in vitro (30 days) and in vivo (14 days) studies. CONCLUSIONS: These preliminary findings demonstrated that the biodegradable PLGA antibiotic beads could achieve a fairly steady antibiotic release in the pleural cavity for at least 2 weeks. This drug delivery system may have the potential to serve as an adjuvant treatment of pleural cavity infection.

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