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Stem Cells and Cancer in Hepatology : From the Essentials to Application

Author: Yun-Wen Zheng
Publisher: London : Academic Press, An imprint of Elsevier, [2018]
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Stem Cells and Cancer in Hepatology: From the Essentials to Application offers basic scientists and clinicians in the fields of stem cells, hepatology and oncology an overview of the interaction between liver biology, stem cells and cancer. It discusses how the liver performs regeneration and repair, the role stem cells play in these processes, and the mechanisms by which liver cancers are initiated and developed.  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
(OCoLC)1011519077
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Yun-Wen Zheng
ISBN: 9780128123027 0128123028
OCLC Number: 1037272347
Description: 1 online resource : colour illustrations.
Contents: Cover; Title Page; Copyright Page; Dedication; Contents; List of Contributors; Editor Biography; Foreword; Liver stem cells: are they real or illusions?; Preface; Acknowledgments; Introduction; References; Chapter 1 --
Molecular Mechanisms of Liver Development: Lessons From Animal Models; 1 --
Introduction; 2 --
Liver development; 2.1 --
Chronology of Liver Bud Formation; 2.2 --
Genes Involved in Liver Bud Formation; 2.3 --
Hepatocyte and Cholangiocyte Differentiation; 2.4 --
Mesothelial Cell Differentiation; 2.5 --
Hepatic Stellate Cell Differentiation; 2.6 --
LSEC Differentiation 2.7 --
Differentiation of Kupffer Cells and Pit Cells3 --
Studies of liver formation using zebrafish; 4 --
Studies of liver formation using medaka; 4.1 --
Group 1: Mutations Affecting Hepatoblast Development; 4.2 --
Group 2: Mutations Affecting Hepatoblast Proliferation; 4.3 --
Group 3: Mutations Affecting Liver Laterality; 4.4 --
Group 4: Mutations Affecting Hemoglobin-Bilirubin Metabolism; 4.5 --
Group 5: Mutations Affecting Lipid Metabolism; 4.6 --
Analysis of Medaka Mutants; 5 --
Studies of liver size regulation in mice; 6 --
Human liver diseases; 6.1 --
Hepatocellular Carcinoma 6.2 --
Metabolic Disorders6.3 --
Alagille Syndrome; 7 --
Conclusion; List of acronyms and abbreviations; References; Chapter 2 --
Molecular Mechanisms Regulating the Proliferation and Maturation of Hepatic Progenitor Cells During Liver Devel...; 1 --
Introduction; 2 --
Liver regeneration and normal liver-derived stem/progenitor cells; 3 --
Regulation of transcription factors regulating the proliferation and maturation of hepatic progenitor cells; 4 --
Signaling pathways regulating hepatoblast proliferation and differentiation; 5 --
Hepatic progenitor cells derived from human pluripotent stem cells 6 --
ConclusionFinancial support and sponsorship; Acknowledgments; List of abbreviations; References; Chapter 3 --
Plasticity of Liver Epithelial Cells in Healthy and Injured Livers; 1 --
Introduction; 2 --
Lineage specification during development; 3 --
Lineage plasticity and heterogeneity of cholangiocytes; 3.1 --
Lineage Plasticity of Cholangiocytes; 3.1.1 --
Fetal and Neonatal Cholangiocytes; 3.1.2 --
Adult Cholangiocytes; 3.2 --
Heterogeneity of Cholangiocytes; 3.3 --
Molecular Mechanisms Regulating the Plasticity of Cholangiocytes; 4 --
Lineage plasticity and heterogeneity of hepatocytes 5.2 --
Histone Modification and Chromatin Structure
Responsibility: edited by Yun-Wen Zheng.

Abstract:

Stem Cells and Cancer in Hepatology: From the Essentials to Application offers basic scientists and clinicians in the fields of stem cells, hepatology and oncology an overview of the interaction between liver biology, stem cells and cancer. It discusses how the liver performs regeneration and repair, the role stem cells play in these processes, and the mechanisms by which liver cancers are initiated and developed. As the field of stem cells and cancer stem cells in hepatology is new and dynamic, thus making it difficult for researchers and clinicians to understand the most relevant historic and novel studies, this volume addresses that challenge.

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