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Genre/Form: | Thèses et écrits académiques |
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Material Type: | Document, Thesis/dissertation, Internet resource |
Document Type: | Internet Resource, Computer File |
All Authors / Contributors: |
Sylvie Beaufils; Pierre Millet, MCU-PH).; Pierre Weiss, maiÌtre de confeÌrences en odontologie).; Jean-Pierre Attal, chirurgien-dentiste).; Ghislaine Bertrand, enseignante-chercheuse).; Anne-Lise Daltin; Hélène Citterio-Bigot; Université de Reims Champagne-Ardenne.; Ecole doctorale Sciences du Numérique et de l'Ingénieur (Reims, Marne).; Laboratoire d'Ingénierie et Sciences des Matériaux (LISM). |
OCLC Number: | 1104746091 |
Notes: | Titre provenant de l'écran-titre. |
Description: | 1 online resource |
Responsibility: | Sylvie Beaufils ; sous la direction de Pierre Millet. |
Abstract:
In order to reduce morbidity and hospital stay, regenerative medicine is nowadays moving towards the development of less invasive surgical techniques. This search for a minimally invasive surgery has motivated the development of injectable matrices for bone tissue engineering. These matrices must also be able to harden in situ once injected, acquire the desired shape and mechanical properties compatible with the host tissue it intends to repair. Many hydrogels are already used for this application but none fully meets the required properties. The objective of this thesis is to develop new bone graft substitutes: hydrogels based on biopolymers associated with bone cells to achieve half synthetic and half biological grafts. Nanoparticles of calcium phosphates are added to improve the biological and mechanical properties of hydrogels. Hydroxyapatite, calcium phosphate chosen, has attracted much attention because of its chemical and structural similarity to the mineral constituent of human bone. The aim of this work is to synthesize firstly hydroxyapatite nanowires by the template method and secondly size controlled hydroxyapatite nanopowders by out-of-phase pulsed sonoelectrochemistry. Thirdly to improve the intrinsic properties of these three-dimensional structures, those nanoparticles of calcium phosphates will be added in the matrices of hydrogel synthesized by the LIOAD. Measurements of diffusion coefficient will be followed by testing cytotoxicity and biocompatibility of those materials. A subcutaneous study and bone model study will follow.
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