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Systems biology of Parkinson's disease

Author: P E Wellstead; Mathieu Cloutier
Publisher: New York, NY : Springer, ©2012.
Edition/Format:  eBook : Document : EnglishView all editions and formats
Publication:Springer eBooks
Summary:
This text is the first to present a study of Parkinson's disease from a Systems Biology perspective. By placing the condition at centre stage, the authors have been able to provide a wide ranging modelling and systems analysis that is focussed on a multi-facetted and highly complex condition. The book comprises a specially selected set of eight studies of important aspects of PD, covering all relevant scales of  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Systems biology of Parkinson's disease.
New York, NY : Springer, ©2012
(DLC) 2012936651
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: P E Wellstead; Mathieu Cloutier
ISBN: 9781461434115 1461434114 1461434106 9781461434108
OCLC Number: 793727751
Description: 1 online resource (xvi, 176 pages)
Contents: Imaging of Dopaminergic Neurons and the Implications for Parkinson's Disease / Wakoto Matsuda --
Modelling and Simulation of Brain Energy Metabolism: Energy and Parkinson's Disease / Peter Wellstead and Mathieu Cloutier --
Systems Biology of Aging: Opportunities for Parkinson's Disease / Andres Kriete --
Mitochondrion- and Endoplasmic Reticulum-Induced SK Channel Dysregulation as a Potential Origin of the Selective Neurodegeneration in Parkinson's Disease / Guillaume Drion, Vincent Seutin and Rodolphe Sepulchre --
Energetics of Ion Transport in Dopaminergic Substantia nigra Neurons / Febe Francis, Míriam R. García and Richard H. Middleton --
Real-Time In Vivo Sensing of Neurochemicals / Fiachra B. Bolger, Niall J. Finnerty and John P. Lowry --
Modeling Protein and Oxidative Metabolism in Parkinson's Disease / Mathieu Cloutier and Peter Wellstead --
Mathematical Models of Dopamine Metabolism in Parkinson's Disease / Zhen Qi, Gary W. Miller and Eberhard O. Voit.
Responsibility: Peter Wellstead, Mathieu Cloutier, editors.

Abstract:

This is particularly true of the pathology of Parkinson's Disease, where recent developments in brain imaging have offered new insights into the morphology of dopaminergic neurons that have profound  Read more...

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From the reviews:"This book is based on the fascinating concept of applying systems biology ... to understand how things work and apply this approach to the study of Parkinson's disease. ... The book Read more...

 
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Primary Entity<\/h3>\n
<http:\/\/www.worldcat.org\/oclc\/793727751<\/a>> # Systems biology of Parkinson\'s disease<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Book<\/a>, schema:MediaObject<\/a>, schema:CreativeWork<\/a> ;\u00A0\u00A0\u00A0\nlibrary:oclcnum<\/a> \"793727751<\/span>\" ;\u00A0\u00A0\u00A0\nlibrary:placeOfPublication<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/1108711416#Place\/new_york_ny<\/a>> ; # New York, NY<\/span>\n\u00A0\u00A0\u00A0\nlibrary:placeOfPublication<\/a> <http:\/\/id.loc.gov\/vocabulary\/countries\/nyu<\/a>> ;\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/id.worldcat.org\/fast\/1745552<\/a>> ; # Systems biology<\/span>\n\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/1108711416#Topic\/parkinson_disease<\/a>> ; # Parkinson Disease<\/span>\n\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/1108711416#Thing\/life_sciences<\/a>> ; # Life sciences.<\/span>\n\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/1108711416#Thing\/biological_models<\/a>> ; # Biological models.<\/span>\n\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/1108711416#Topic\/systems_biology<\/a>> ; # Systems Biology<\/span>\n\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/1108711416#Thing\/medicine<\/a>> ; # Medicine.<\/span>\n\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/1108711416#Topic\/health_&_fitness_diseases_alzheimer_s_&_dementia<\/a>> ; # HEALTH & FITNESS--Diseases--Alzheimer\'s & Dementia<\/span>\n\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/1108711416#Thing\/neurosciences<\/a>> ; # Neurosciences.<\/span>\n\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/1108711416#Thing\/biomedicine_general<\/a>> ; # Biomedicine general.<\/span>\n\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/1108711416#Topic\/parkinson_s_disease_simulation_methods<\/a>> ; # Parkinson\'s disease--Simulation methods<\/span>\n\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/1108711416#Topic\/medical_neurology<\/a>> ; # MEDICAL--Neurology<\/span>\n\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/1108711416#Thing\/systems_biology<\/a>> ; # Systems Biology.<\/span>\n\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/dewey.info\/class\/616.833011\/e23\/<\/a>> ;\u00A0\u00A0\u00A0\nschema:bookFormat<\/a> schema:EBook<\/a> ;\u00A0\u00A0\u00A0\nschema:contributor<\/a> <http:\/\/viaf.org\/viaf\/250756088<\/a>> ; # Mathieu Cloutier<\/span>\n\u00A0\u00A0\u00A0\nschema:contributor<\/a> <http:\/\/viaf.org\/viaf\/13606777<\/a>> ; # P. E. Wellstead<\/span>\n\u00A0\u00A0\u00A0\nschema:copyrightYear<\/a> \"2012<\/span>\" ;\u00A0\u00A0\u00A0\nschema:datePublished<\/a> \"2012<\/span>\" ;\u00A0\u00A0\u00A0\nschema:description<\/a> \"This text is the first to present a study of Parkinson\'s disease from a Systems Biology perspective. By placing the condition at centre stage, the authors have been able to provide a wide ranging modelling and systems analysis that is focussed on a multi-facetted and highly complex condition. The book comprises a specially selected set of eight studies of important aspects of PD, covering all relevant scales of space and time. These are used to show how innovative sensing techniques, mathematical modelling, model analysis and computational simulation can throw new light on the dynamics of disease mechanisms that drive this important form of neurodegeneration.<\/span>\"@en<\/a> ;\u00A0\u00A0\u00A0\nschema:exampleOfWork<\/a> <http:\/\/worldcat.org\/entity\/work\/id\/1108711416<\/a>> ;\u00A0\u00A0\u00A0\nschema:genre<\/a> \"Electronic books<\/span>\"@en<\/a> ;\u00A0\u00A0\u00A0\nschema:inLanguage<\/a> \"en<\/span>\" ;\u00A0\u00A0\u00A0\nschema:isSimilarTo<\/a> <http:\/\/worldcat.org\/entity\/work\/data\/1108711416#CreativeWork\/systems_biology_of_parkinson_s_disease<\/a>> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Systems biology of Parkinson\'s disease<\/span>\"@en<\/a> ;\u00A0\u00A0\u00A0\nschema:productID<\/a> \"793727751<\/span>\" ;\u00A0\u00A0\u00A0\nschema:publication<\/a> <http:\/\/www.worldcat.org\/title\/-\/oclc\/793727751#PublicationEvent\/new_york_ny_springer_2012<\/a>> ;\u00A0\u00A0\u00A0\nschema:publisher<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/1108711416#Agent\/springer<\/a>> ; # Springer<\/span>\n\u00A0\u00A0\u00A0\nschema:url<\/a> <http:\/\/link.springer.com\/openurl?genre=book&isbn=978-1-4614-3410-8<\/a>> ;\u00A0\u00A0\u00A0\nschema:url<\/a> <https:\/\/doi.org\/10.1007\/978-1-4614-3411-5<\/a>> ;\u00A0\u00A0\u00A0\nschema:url<\/a> <http:\/\/books.scholarsportal.info\/viewdoc.html?id=\/ebooks\/ebooks2\/springer\/2012-05-29\/1\/9781461434115<\/a>> ;\u00A0\u00A0\u00A0\nschema:url<\/a> <http:\/\/www.vlebooks.com\/vleweb\/product\/openreader?id=none&isbn=9781461434115<\/a>> ;\u00A0\u00A0\u00A0\nschema:url<\/a> <http:\/\/link.springer.com\/10.1007\/978-1-4614-3411-5<\/a>> ;\u00A0\u00A0\u00A0\nschema:url<\/a> <https:\/\/link.springer.com\/openurl?genre=book&isbn=978-1-4614-3410-8<\/a>> ;\u00A0\u00A0\u00A0\nschema:url<\/a> <http:\/\/dx.doi.org.ezproxy.aub.edu.lb\/10.1007\/978-1-4614-3411-5<\/a>> ;\u00A0\u00A0\u00A0\nschema:url<\/a> <http:\/\/site.ebrary.com\/id\/10562472<\/a>> ;\u00A0\u00A0\u00A0\nschema:url<\/a> <https:\/\/0-link-springer-com.pugwash.lib.warwick.ac.uk\/10.1007\/978-1-4614-3411-5<\/a>> ;\u00A0\u00A0\u00A0\nschema:url<\/a> <https:\/\/search.ebscohost.com\/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=511163<\/a>> ;\u00A0\u00A0\u00A0\nschema:url<\/a> <http:\/\/www.library.yorku.ca\/e\/resolver\/id\/2336866<\/a>> ;\u00A0\u00A0\u00A0\nschema:url<\/a> <http:\/\/public.ebookcentral.proquest.com\/choice\/publicfullrecord.aspx?p=973602<\/a>> ;\u00A0\u00A0\u00A0\nschema:workExample<\/a> <http:\/\/worldcat.org\/isbn\/9781461434108<\/a>> ;\u00A0\u00A0\u00A0\nschema:workExample<\/a> <http:\/\/worldcat.org\/isbn\/9781461434115<\/a>> ;\u00A0\u00A0\u00A0\nwdrs:describedby<\/a> <http:\/\/www.worldcat.org\/title\/-\/oclc\/793727751<\/a>> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n\n

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<http:\/\/dewey.info\/class\/616.833011\/e23\/<\/a>>\u00A0\u00A0\u00A0\u00A0a \nschema:Intangible<\/a> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/dx.doi.org.ezproxy.aub.edu.lb\/10.1007\/978-1-4614-3411-5<\/a>>\u00A0\u00A0\u00A0\nrdfs:comment<\/a> \"Click for electronic access to e-book (off-campus access)<\/span>\" ;\u00A0\u00A0\u00A0\nrdfs:comment<\/a> \"Click for electronic access to e-book<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/1108711416#Agent\/springer<\/a>> # Springer<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nbgn:Agent<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Springer<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/1108711416#Place\/new_york_ny<\/a>> # New York, NY<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Place<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"New York, NY<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/1108711416#Thing\/biological_models<\/a>> # Biological models.<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Thing<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Biological models.<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/1108711416#Thing\/biomedicine_general<\/a>> # Biomedicine general.<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Thing<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Biomedicine general.<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/1108711416#Thing\/life_sciences<\/a>> # Life sciences.<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Thing<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Life sciences.<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/1108711416#Thing\/medicine<\/a>> # Medicine.<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Thing<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Medicine.<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/1108711416#Thing\/neurosciences<\/a>> # Neurosciences.<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Thing<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Neurosciences.<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/1108711416#Thing\/systems_biology<\/a>> # Systems Biology.<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Thing<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Systems Biology.<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/1108711416#Topic\/health_&_fitness_diseases_alzheimer_s_&_dementia<\/a>> # HEALTH & FITNESS--Diseases--Alzheimer\'s & Dementia<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Intangible<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"HEALTH & FITNESS--Diseases--Alzheimer\'s & Dementia<\/span>\"@en<\/a> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/1108711416#Topic\/medical_neurology<\/a>> # MEDICAL--Neurology<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Intangible<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"MEDICAL--Neurology<\/span>\"@en<\/a> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/1108711416#Topic\/parkinson_disease<\/a>> # Parkinson Disease<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Intangible<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Parkinson Disease<\/span>\"@en<\/a> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/1108711416#Topic\/parkinson_s_disease_simulation_methods<\/a>> # Parkinson\'s disease--Simulation methods<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Intangible<\/a> ;\u00A0\u00A0\u00A0\nschema:hasPart<\/a> <http:\/\/id.loc.gov\/authorities\/subjects\/sh85098115<\/a>> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Parkinson\'s disease--Simulation methods<\/span>\"@en<\/a> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/1108711416#Topic\/systems_biology<\/a>> # Systems Biology<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Intangible<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Systems Biology<\/span>\"@en<\/a> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/id.loc.gov\/vocabulary\/countries\/nyu<\/a>>\u00A0\u00A0\u00A0\u00A0a \nschema:Place<\/a> ;\u00A0\u00A0\u00A0\ndcterms:identifier<\/a> \"nyu<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/id.worldcat.org\/fast\/1745552<\/a>> # Systems biology<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Intangible<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Systems biology<\/span>\"@en<\/a> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/viaf.org\/viaf\/13606777<\/a>> # P. E. Wellstead<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Person<\/a> ;\u00A0\u00A0\u00A0\nschema:familyName<\/a> \"Wellstead<\/span>\" ;\u00A0\u00A0\u00A0\nschema:givenName<\/a> \"P. E.<\/span>\" ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"P. E. Wellstead<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/viaf.org\/viaf\/250756088<\/a>> # Mathieu Cloutier<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Person<\/a> ;\u00A0\u00A0\u00A0\nschema:familyName<\/a> \"Cloutier<\/span>\" ;\u00A0\u00A0\u00A0\nschema:givenName<\/a> \"Mathieu<\/span>\" ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Mathieu Cloutier<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/worldcat.org\/entity\/work\/data\/1108711416#CreativeWork\/systems_biology_of_parkinson_s_disease<\/a>>\u00A0\u00A0\u00A0\u00A0a \nschema:CreativeWork<\/a> ;\u00A0\u00A0\u00A0\nrdfs:label<\/a> \"Systems biology of Parkinson\'s disease.<\/span>\" ;\u00A0\u00A0\u00A0\nschema:description<\/a> \"Print version:<\/span>\" ;\u00A0\u00A0\u00A0\nschema:isSimilarTo<\/a> <http:\/\/www.worldcat.org\/oclc\/793727751<\/a>> ; # Systems biology of Parkinson\'s disease<\/span>\n\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
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<http:\/\/worldcat.org\/isbn\/9781461434115<\/a>>\u00A0\u00A0\u00A0\u00A0a \nschema:ProductModel<\/a> ;\u00A0\u00A0\u00A0\nschema:isbn<\/a> \"1461434114<\/span>\" ;\u00A0\u00A0\u00A0\nschema:isbn<\/a> \"9781461434115<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
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