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Target discovery and validation. Volume 361, Part 2, Emerging molecular targets and treatment options : reviews and protocols

Author: Mouldy Sioud
Publisher: Totowa, N.J. : Humana Press, ©2007.
Series: Methods in molecular biology (Clifton, N.J.), volume 361, pt. 2.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Target Discovery and Validation Reviews and Protocols, Volumes 1 and 2 review the most progressive and current methods for drug target discovery and validation. These volumes explore how recent improvement in understanding the molecular mechanisms of human pathology is impacting drug target discovery in the laboratory and in real therapeutics, specifically for cancers and autoimmune disorders. Volume 1 focuses on  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Target discovery and validation. Volume 2, Emerging molecular targets and treatment options.
Totowa, N.J. : Humana Press, ©2007
(DLC) 2006020032
(OCoLC)70164446
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Mouldy Sioud
ISBN: 9781597452083 1597452084 9781588298904 1588298906
OCLC Number: 184984485
Description: 1 online resource (1 volume) : illustrations.
Contents: Main Approaches to Target Discovery and Validation / Mouldy Sioud --
Bioinformatics Approaches to Cancer Gene Discovery / Ramaswamy Narayanan --
Analysis of Gene Networks for Drug Target Discovery and Validation / Seiya Imoto [and others] --
Target Discovery and Validation in Pancreatic Cancer / Robert M. Beaty [and others] --
Molecular Classification of Breast Tumors: Toward Improved Diagnostics and Treatments / Therese Sørlie --
Discovery of Differentially Expressed Genes: Technical Considerations / Øystein Røsok and Mouldy Sioud --
Genome-Wide Screening by Using Small-Interfering RNA-Expression Libraries / Sahohime Matsumoto, Makoto Miyagishi, and Kazunari Taira --
Hammerhead Ribozyme-Based Target Discovery / Masayuki Sano and Kazunari Taira --
Production of siRNA and cDNA-Transfected Cell Arrays on Noncoated Chambered Coverglass for High-Content Screening Microscopy in Living Cells / Holger Erfle and Rainer Pepperkok --
Transgenic Animal Models in Biomedical Research / Louis-Marie Houdebine --
Keratin Trangenic and Knockout Mice: Functional Analysis and Validation of Disease-Causing Mutations / Preethi Vijayaraj, Goran Söhl, and Thomas M. Magin --
The HUVEC/Matrigel Assay: An In Vivo Assay of Human Angiogenesis Suitable for Drug Validation / Dag K. Skovseth, Axel M. Küchler, and Guttorm Haraldsen --
A Murine Model for Studying Hematopoiesis and Immunity in Heart Failure / Per Ole Iversen and Dag R. Sørensen --
An Overview of the Immune System and Technical Advances in Tumor Antigen Discovery and Validation / Mouldy Sioud --
Potential Target Antigens for Immunotherapy Identified by Serological Expression Cloning (SEREX) / Dirk Jäger --
Identification of Tumor Antigens by Using Proteomics / Francois Le Naour --
Protein Arrays: A Versatile Toolbox for Target Identification and Monitoring of Patient Immune Responses / Lina Cekaite, Eivind Hovig, and Mouldy Sioud --
Index.
Series Title: Methods in molecular biology (Clifton, N.J.), volume 361, pt. 2.
Other Titles: Emerging molecular targets and treatment options
Responsibility: edited by Mouldy Sioud.
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Abstract:

These volumes review the most current methods for drug target discovery and validation. They explore how recent improvement in understanding the molecular mechanisms of human pathology is impacting  Read more...

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From the reviews:"...provide a thorough review of the most cutting-edge methods available for each step in drug target identification, validation, and clinical applications." -Anticancer Read more...

 
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