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Targeting trafficking in drug development

Author: Alfredo Ulloa-Aguirre; Ya-Xiong Tao
Publisher: Cham, Switzerland : Springer, 2018.
Series: Handbook of experimental pharmacology, v. 245.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Cellular trafficking is only recently identified as a site for therapeutic intervention. This book provides up to date information on the mechanism for exploiting this area for drug development as well as a clear understanding of the individual components of cellular trafficking. The authors are experts in their areas and the book features tables and figures that enable comparison and clear understanding.
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Targeting trafficking in drug development.
Cham, Switzerland : Springer, 2018
(OCoLC)1015997649
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Alfredo Ulloa-Aguirre; Ya-Xiong Tao
ISBN: 9783319741642 3319741640
OCLC Number: 1031999137
Description: 1 online resource (viii, 425 pages) : illustrations
Contents: 1. Intracellular trafficking of gonadotropin receptors in health and disease --
2. Investigating internalization and intracellular trafficking of GPCRs --
3. Pharmacological chaperones as potential therapeutic strategies for misfolded mutant vasopressin receptors --
4. Targeting of disordered proteins by small molecules in neurodegenerative diseases --
5. Pharmacoperones for misfolded gonadotropin receptors --
6. Pharmacological chaperones: Beyond conformational disorders --
7. Natural (and unnatural) small molecules as pharmacological chaperones and inhibitors in cancer --
8. Heritable skeletal disorders arising from defects in processing and transport of Type I procollagen from the ER: perspectives on possible therapeutic approaches --
9. Conserved oligomeric Golgi and neuronal vesicular trafficking --
10. SLC6 transporter folding diseases and pharmacochaperoning --
11. The molecular physiopathogenesis of islet amyloidosis --
12. Folding defects leading to primary hyperoxaluria --
13. Potential pharmacological chaperones for cystathionine beta-synthase-deficient homocystinuria.
Series Title: Handbook of experimental pharmacology, v. 245.
Responsibility: Alfredo Ulloa-Aguirre, Ya-Xiong Tao, editors.

Abstract:

This book provides up to date information on the mechanism for exploiting this area for drug development as well as a clear understanding of the individual components of cellular trafficking. The  Read more...

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