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Test No. 319B: Determination of in vitro intrinsic clearance using rainbow trout liver S9 sub-cellular fraction (RT-S9)

Author: Organisation for Economic Co-operation and Development.
Publisher: Paris : OECD Publishing, 2018.
Series: OECD Guidelines for the Testing of Chemicals, Section 3
Edition/Format:   eBook : Document : International government publication : EnglishView all editions and formats
Summary:
The Test Guideline (TG) describes the use of liver S9 sub-cellular fraction (RT-S9) of rainbow trout (Oncorhynchus mykiss) as a metabolising system to determine the clearance (CL, IN VITRO, INT) of a test chemical using a substrate depletion approach. Introduction of the test chemical to the RT-S9 incubation medium initiates the reaction. In order to collect samples at various time points, the reaction is terminated  Read more...
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Material Type: Document, Government publication, International government publication, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Organisation for Economic Co-operation and Development.
ISBN: 9789264303232 9264303235
OCLC Number: 1045260408
Description: 1 online resource
Series Title: OECD Guidelines for the Testing of Chemicals, Section 3
Responsibility: Organisation for Economic Co-operation and Development.

Abstract:

The Test Guideline (TG) describes the use of liver S9 sub-cellular fraction (RT-S9) of rainbow trout (Oncorhynchus mykiss) as a metabolising system to determine the clearance (CL, IN VITRO, INT) of a test chemical using a substrate depletion approach. Introduction of the test chemical to the RT-S9 incubation medium initiates the reaction. In order to collect samples at various time points, the reaction is terminated by transferring an aliquot of the medium to a stopping solution. The decrease of the test chemical concentration from the incubation vial is measured with a validated analytical method and used to determine the CL, IN VITRO, INT. The value obtained can then be used to improve in silico predictions of the test chemical bioaccumulation in fish.

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