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Textbook of drug design and discovery

Author: Povl Krogsgaard-Larsen; Kristian Strømgaard; Ulf Madsen
Publisher: Boca Raton, FL : CRC Press/Taylor & Francis, ©2010.
Edition/Format:   Print book : English : 4th edView all editions and formats
Gives comprehensive information on various aspects of drug design and discovery. This title describes the specific strategies employed by medicinal chemists to advance promising molecules into clinical use for the alleviation of disease.

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Genre/Form: Aufsatzsammlung
Material Type: Internet resource
Document Type: Book, Internet Resource
All Authors / Contributors: Povl Krogsgaard-Larsen; Kristian Strømgaard; Ulf Madsen
ISBN: 9781420063226 1420063227 9781420063264 142006326X
OCLC Number: 317664333
Description: xv, 460 pages : illustrations (some color) ; 27 cm
Contents: Molecular recognition in ligand-protein binding / Tommy Liljefors --
Biostructure-based drug design / Flemming S. Jørgensen and Jette S. Kastrup --
Ligand-based drug design / Ingrid Pettersson, Thomas Balle, and Tommy Liljefors --
Chemical biology / Kristian Strømgaard --
Stereochemistry in drug design / M. Belen Mayo-Martin and David E. Jane --
Natural products in drug discovery / Guy T. Carter --
Imaging in drug discovery and development / Markus Rudin and Thomas Mueggler --
Peptides and peptidomimetics / Minying Cai, Vinod Kulkarni, and Victor J. Hruby --
Prodrugs : design and development / Anders Buur and Niels Mørk --
Metals in medicine : inorganic medicinal chemistry / Helle R. Hansen and Ole Farver --
Enzyme inhibitors : biostructure-based and mechanism-based designs / Robert A. Copeland, Richard R. Gontarek, and Lusong Luo --
Receptors : structure, function, and pharmacology / Hans Bräuner-Osborne --
Ion channels : structure and function / Søren-Peter Olesen and Daniel B. Timmermann --
Neurotransmitter transporters : structure and function / Claus J. Loland and Ulrik Gether --
GABA and glutamic acid receptor ligands / Bente Frølund and Ulf Madsen --
Acetylcholine / Anders A. Jensen and Povl Krogsgaard-Larsen --
Histamine receptors / Iwan de Esch, Henk Timmerman and Rob Leurs --
Dopamine and serotonin / Benny Bang-Andersen and Klaus P. Bøgesø --
Opioid and cannabinoid receptors / Rasmus P. Clausen and Harald S. Hansen --
Hypnotics / Bjarke Ebert and Keith Wafford --
Neglected diseases / Søren B. Christensen --
Immunomodulating agents / Ulla G. Sidelmann --
Anticancer agents / Fredrik Bjørkling and Lars H. Jensen --
Antiviral drugs / Erik De Clercq --
Antibiotics / Piet Herdewijn.
Responsibility: edited by Povl Krogsgaard-Larsen, Kristian Strømgaard, Ulf Madsen.


The molecular biological revolution and the mapping of the human genome continue to provide fresh challenges. This book describes the manner in which medicinal chemists utilize the various fields  Read more...


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"... figures are relevant and helpful in explaining concepts in the text. The level of detail in the contents of the book makes it especially suitable for academics and advanced students of medicinal Read more...

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