The Inferior Olive: coupling, oscillations and bursting activity (Book, 2013) [WorldCat.org]
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The Inferior Olive: coupling, oscillations and bursting activity

Author: Paolo Bazzigaluppi
Publisher: Erasmus University Rotterdam 2013-06-11
Edition/Format: Book Book : English
Summary:
textabstractThe inferior olive is part of the olivo-cerebellar system and it plays a key role becauseit provides one of the major sensory inputs to the cerebellar cortex. Forthis reason, we wanted to answer those questions about the physiology of olivaryneurons that still were unanswered. We dedicated our efforts in the first place toexplore the inhibitory input to the IO, namely the nucleo-olivary projection,  Read more...
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Details

Document Type: Book
All Authors / Contributors: Paolo Bazzigaluppi
ISBN: 978-94-6182-293-2
Language Note: English
Unique Identifier: 6892876883
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Abstract:

textabstractThe inferior olive is part of the olivo-cerebellar system and it plays a key role becauseit provides one of the major sensory inputs to the cerebellar cortex. Forthis reason, we wanted to answer those questions about the physiology of olivaryneurons that still were unanswered. We dedicated our efforts in the first place toexplore the inhibitory input to the IO, namely the nucleo-olivary projection, andthe role GABA plays in re-setting the phase of the subthreshold oscillations (chapter2). After investigating the inputs of the IO, we focused on the electrotonicalcoupling and we explored the pathways that regulate the coupling between olivaryneurons. We determined that the phosphorylation of Cx36 is one of these mechanismsand we identified that CaMKII and PKA play a role in this pathway, the firstsustaining and the latter reducing the coupling between olivary neurons (chapter 3).We then focused on the output of the olivary neurons, investigating the variablesthat were influencing the bursting activity of olivary neurons. We performed theseexperiments in vivo, because we wanted to investigate the relationship betweenspikelets and oscillations in an intact network, which was also able to convey somatosensoryinformation (chapter 4). We could conclude that in our experimentalcondition the phase relationship between the phase of the SSTOs and the spikelet count was not present, whereas the amplitude of the SSTOs was determining thenumber of the spikelets. We then generated a computer model bridging our in vivoresults with the ones obtained in vitro by Mathy et al. (2009) (chapter 5).

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