The role of fibrinogen variants in cardiovascular diseases and wound healing (Book, 2012) [WorldCat.org]
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The role of fibrinogen variants in cardiovascular diseases and wound healing

Author: Elim Cheung
Publisher: Erasmus University Rotterdam 2012-06-26
Edition/Format: Book Book : English
Summary:
textabstractMaintaining the integrity and patency of the vascular system is essential for the viabilityof humans. When vascular injury has occurred, fast formation of a thrombus at thesite of injury is essential to seal the wound, resulting in haemostasis. Haemostasis is atightly regulated process, which involves the activation of endothelial cells, platelets,procoagulants and the inhibition of fibrinolytic factors.  Read more...
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Details

Document Type: Book
All Authors / Contributors: Elim Cheung
ISBN: 978-94-6191-334-0
Language Note: English
Unique Identifier: 6892891142
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Abstract:

textabstractMaintaining the integrity and patency of the vascular system is essential for the viabilityof humans. When vascular injury has occurred, fast formation of a thrombus at thesite of injury is essential to seal the wound, resulting in haemostasis. Haemostasis is atightly regulated process, which involves the activation of endothelial cells, platelets,procoagulants and the inhibition of fibrinolytic factors. Haemostasis can be separatedin two phases called primary and secondary haemostasis, which occur simultaneously.1In primary haemostasis, a platelets plug is rapidly formed at the site of injury, whereasin secondary haemostasis, blood coagulation is initiated, either with negatively chargedsurfaces (intrinsic pathway) or with tissue factor (extrinsic pathway). The cascade leads tothe generation of thrombin and the formation of a fibrin network.2 The thrombus providesan effective restriction for bleeding. Hence, an imbalance of normal haemostasis causedby pathologic disorders may lead to thrombosis or hemorrhage, which may account formorbidity and mortality.Fibrinogen is a central protein in the hemostatic system. At the final stage of the bloodcoagulation system, thrombin converts the soluble fibrinogen into fibrin monomers,which then polymerize to an insoluble fibrin clot. Furthermore, fibrinogen induces plateletadhesion and aggregation via the αIIbβ3 integrin, thus promoting blood coagulation.In addition to their primary function in blood clotting, fibrinogen and fibrin alsoplay a role in various physiological reactions including fibrinolysis, cellular and matrixinteractions, wound healing and neoplasia.

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