The Role of the Epicardium in Heart Development (Book, 2009) [WorldCat.org]
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The Role of the Epicardium in Heart Development

Author: Ismail Eralp
Publisher: Erasmus University Rotterdam 2009-09-30
Edition/Format: Book Book : English
Summary:
textabstractIn early embryonic life, the primitive heart tube consists of two layers, the myocardium and the endocardium.Eventually the heart tube loops to form a four-chambered structure providing for a circulation of blood byrhythmic contractions of the myocardium. With the increase in heart size and myocardial work load, a separatevasculature for the free myocardial wall is required. The formation of this  Read more...
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Details

Document Type: Book
All Authors / Contributors: Ismail Eralp
ISBN: 978-90-90-24516-4
Language Note: English
Unique Identifier: 6893691337
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Abstract:

textabstractIn early embryonic life, the primitive heart tube consists of two layers, the myocardium and the endocardium.Eventually the heart tube loops to form a four-chambered structure providing for a circulation of blood byrhythmic contractions of the myocardium. With the increase in heart size and myocardial work load, a separatevasculature for the free myocardial wall is required. The formation of this coronary system is preceeded by theoutgrowth of the epicardium, covering the naked heart tube. Our studies were performed on quail and chickenembryos, because of the high resemblance with human cardiac development. Avian embryos develop inapproximately three weeks and were staged according to the Hamburger&Hamilton (HH) stages. In avianembryos the epicardial development starts at stage HH15 which is at three days of embryonic development, andis completed at stage HH25, which is after seven days of incubation. Epicardial cells are derived from theproepicardial organ (PEO), that protrudes as a cauliflower-like structure from the mesothelial lining of the bodycavity near the sinus venosus and primitive liver, towards the inner curvature of the heart. The villi of the PEOreach the heart at the posterior atrial side where the sinus venosus myocardium is incorporated and the epicardialcells start to spread over the naked heart tube, until they eventually cover the myocardium completely.

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