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Thermodynamics and biophysics of biomedical nanosystems : applications and practical considerations

Author: Costas Demetzos; Natassa Pippa
Publisher: Singapore : Springer, 2019.
Series: Series in bioengineering
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
This book highlights the recent advances of thermodynamics and biophysics in drug delivery nanosystems and in biomedical nanodevices. The up-to-date book provides an in-depth knowledge of bio-inspired nanotechnological systems for pharmaceutical applications. Biophysics and thermodynamics, supported by mathematics, are the locomotive by which the drug transportation and the targeting processes will be achieved under  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Demetzos, Costas.
Thermodynamics and Biophysics of Biomedical Nanosystems : Applications and Practical Considerations.
Singapore : Springer, ©2019
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Costas Demetzos; Natassa Pippa
ISBN: 9789811309892 9811309892 9811309884 9789811309885 9789811309908 9811309906
OCLC Number: 1089693351
Description: 1 online resource (xii, 475 pages) : illustrations (some color)
Contents: Intro; Preface; Contents; About the Editors; Introducing Thermodynamics and Biophysics in Health Sciences; 1 Thermodynamics and Biophysics in Biomaterials and Self-assembled Structures; 2 Thermal Analysis Techniques in Design and Development of Medicines; 3 Liquid Crystalline Phases: Trying to Understudy the Physics of Bio-Inspired Systems; 3.1 The Metastable Phases; 4 Nanosimilars: The Role of Thermodynamics for the Approval of the Next-Generation Nanomedicines; 5 Regulatory and Concluding Remarks; References Methodological Approaches for the Characterization of the Self-assembling Behaviour in the Pharmaceutical Field1 Self-assembly: A Ubiquitous Phenomenon; 1.1 Definition and Thermodynamic Basis of Self-assembly; 2 Pharmaceutical and Biomedical Applications of Self-assembling; 2.1 Self-assembled Polymeric Nanosystems; 2.2 Self-assembled Lipidic Nanosystems; 2.3 Self-assembled Inorganic Nanosystems; 2.4 Self-assembled Macromolecular (Biological) Nanosystems; 3 Characterization of the Self-assembling Behaviour of Pharmaceutical and Biomedical Nanosystems; 3.1 Ultrasound Spectroscopy Techniques 3.2 Calorimetric Techniques4 Conclusions; References; Phase Transitions in Biological Membranes; 1 Introduction; 2 Membrane Melting; 3 Influence of Anesthetic Drugs on Membrane Transitions; 4 Pressure Reveral of Anesthesia; 5 Influencing the Melting Transition by pH, Sodium, Potassium, Calcium and Other Charged Ligands; 6 Elastic Constants and Time Scales; 7 Voltage, Capacitance and Transitions; 8 Permeability and Channels; 9 Pulses Along Membranes; 10 Influence of the Thermodynamic Variables on the Excitability of Nerves; 11 Summary; References Isothermal Titration Calorimetry: A Powerful Tool for the Characterization of Molecular Interactions1 Introduction; 2 Basic Concepts, Experimental Procedure and Data Analysis; 2.1 Device Design and Experimental Procedure; 2.2 Design of an ITC Experiment; 2.3 Experimental Results and Data Analysis; 3 Applications; 3.1 The Value of ITC in Rational Drug Design; 3.2 Nanoparticle-Protein Interactions; 3.3 Polyelectrolyte Interactions; 3.4 Interactions of Lipid-Based Systems; 3.5 Cyclodextrin Interactions; 4 Conclusions; References Dynamics of Iron Homeostasis in Health and Disease: Molecular Mechanisms and Methods for Iron Determination1 Introduction; 2 Systemic Iron Homeostasis; 3 Cellular Iron Homeostasis; 3.1 Cellular Iron Uptake and Utilization; 3.2 Regulation of Cellular Iron Homeostasis; 4 Mitochondrial Iron Homeostasis; 4.1 Mitochondrial Iron Import; 4.2 Iron-Sulfur Cluster Biosynthesis; 4.3 Heme Biosynthesis; 4.4 Mitochondrial Iron Storage; 5 Iron Dyshomeostasis in Pathological Conditions and Ageing; 5.1 Friedrich's Ataxia; 5.2 Parkinson's Disease; 5.3 Alzheimer's Disease; 5.4 Congenital Sideroblastic Anemias
Series Title: Series in bioengineering
Responsibility: Costas Demetzos, Natassa Pippa, editors.

Abstract:

This book highlights the recent advances of thermodynamics and biophysics in drug delivery nanosystems and in biomedical nanodevices.  Read more...

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