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Thyroid Hormone

Author: Gerald Litwack
Publisher: Cambaridge, MA, United States : Academic Press, 2018.
Series: Vitamins and hormones, v. 106.
Edition/Format:   eBook : Document : English : First editionView all editions and formats
Summary:
Thyroid hormone, Volume 106, the latest release in the Vitamins and Hormones series first published in 1943 provides up-to-date information on crystal structures and basic structural studies on neurotrophins and their receptors, neurotrophin functions and the biological actions of neurotrophins related to clinical conditions and disease. This new release focuses on timely topics, including the Nuclear Import and  Read more...
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Additional Physical Format: Print version:
(OCoLC)1054105801
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Gerald Litwack
ISBN: 9780128141175 0128141174 9780128141168 0128141166
OCLC Number: 1020172350
Language Note: Text in English.
Description: 1 online resource (xx, 544 pages : illustrations).
Contents: Thyroid Hormone Receptor Antagonists: From Environmental Pollution to Novel Small Molecules Louise S. Mackenzie 8. Thyroid Hormone Stimulation of Adult Brain Fatty Acid Oxidation Mikaela M. Sifuentes and James D. Lechleiter 9. The NF--[kappa]B Family of Transcription Factors and Its Role in Thyroid Physiology Carla Reale, Tiziana Zotti, Ivan Scudiero, Pasquale Vito and Romania Stilo 10. Thyroid Hormone Regulation of Adult Neurogenesis Sashaina E. Fanibunda, Lynette A. Desouza, Richa Kapoor, Rama A. Vaidya and Vidita A. Vaidya 11. Thyroid Hormone and the White Matter of the Central Nervous System: From Development to Repair Laura Calzà, Vito A. Baldassarro, Mercedes Fernandez, Alessandro Giuliani, Luca Lorenzini and Luciana Giardino 12. 1. Local Regulation of Thyroid Hormone Signaling Alexander G. Little 2. Thyroid Hormone Transport and Transporters Doreen Braun and Ulrich Schweizer 3. Nuclear Import and Export of the Thyroid Hormone Receptor Jibo Zhang, Vincent R. Roggero and Lizabeth A. Allison 4. Molecular Basis of Nongenomic Actions of Thyroid Hormone Paul J. Davis, Jack L. Leonard, Hung-Yun Lin, Matthew Leinung and Shaker A. Mousa 5. The Mechanism of Negative Transcriptional Regulation by Thyroid Hormone: Lessons From the Thyrotropin [Beta] Subunit Gene Shigekazu Sasaki, Akio Matsushita, Go Kuroda, Hiroko M. Nakamura, Yutaka Oki and Takafumi Suda 6. Thyroid Autoimmunity: An Interplay of Factors Stephen J. Merrill and Sarah B. Minucci 7. Front Cover; Thyroid Hormone; Copyright; Former Editors; Contents; Contributors; Preface; Chapter One: Local Regulation of Thyroid Hormone Signaling; 1. Introduction; 2. Bioavailability; 2.1. TH Transporters; 2.2. Deiodinases; 2.3. Intracellular Reservoir Proteins; 3. Bioactivity; 3.1. Thyroid Receptors; 3.2. Integrin αvÃ#x9F;3; 3.3. Thyroid Response Elements; 4. Conclusions; References; Further Reading; Chapter Two: Thyroid Hormone Transport and Transporters; 1. Introduction; 2. Thyroid hormone Transport; 3. Monocarboxylate Transporter 8; 3.1. The Syndrome of Inherited MCT8 Deficiency 3.2. Mutations in MCT8 Impair Thyroid Hormone Transport3.3. Concepts for Treatment of MCT8 Deficiency; 3.3.1. Raising Low T4; 3.3.2. Lowering Elevated T3; 3.3.3. Replacing Thyroid Hormone With an MCT8-Independent Agonist; 4. Mouse Models of Allan-Herndon-Dudley Syndrome; 5. Thyroid Hormone Transport and Physiology; 6. Further Clinical Implications for Thyroid Hormone Transporters; 6.1. Polymorphisms in Thyroid Hormone Transporters May Affect Thyroid Hormone Levels; 6.2. Inhibition of Thyroid Hormone Transport by Drugs; 6.3. Intestinal Uptake of T4 and Thyroid Hormone Transport 7. Conclusions and Future DirectionsAcknowledgments; References; Chapter Three: Nuclear Import and Export of the Thyroid Hormone Receptor; 1. Introduction; 2. Thyroid Hormone Receptor Nucleocytoplasmic Shuttling; 2.1. Translocation Through the Nuclear Pore Complexes; 2.2. Analysis of Nucleocytoplasmic Shuttling in Live Cells; 3. Nuclear Import Pathways of TR; 3.1. NLSs in TRα1; 3.1.1. Hinge Domain NLS; 3.1.2. A/B Domain NLS; 3.2. Importins That Mediate TRα1 Nuclear Import; 3.2.1. Importin α1/Ã#x9F;1 Heterodimer; 3.2.2. Importin 7; 4. Nuclear Export Pathways of TRα1; 4.1. NESs in TRα1 4.1.1. NES-H124.1.2. NES-H3 and NES-H6; 4.2. Exportins That Mediate TRα1 Nuclear Export; 4.2.1. CRM1; 4.2.2. Exportins 4, 5, and 7; 5. Mislocalization of TR and Pathogenesis; 5.1. TR Mislocalization and Cancer; 5.2. TR Mislocalization and RTH Syndrome; 6. Conclusions and Future Directions; Acknowledgments; References; Chapter Four: Molecular Basis of Nongenomic Actions of Thyroid Hormone; 1. Introduction; 2. Regulation of the State of the Cytoskeleton by Thyroid Hormone; 3. Regulation of Mitochondrial Respiration by Thyroid Hormone 4. Nongenomic Actions of Truncated and Intact TRs in Cytoplasm on Bone Cells, Neurons, and Tumor Suppression5. Cytoplasmic Proteins in Addition to TRs That Mediate Nongenomic Actions of Thyroid Hormone; 6. Nongenomic Actions of Thyroid Hormone Initiated at Plasma Membrane; 7. Thyroid Hormone Receptor on Plasma Membrane Integrin αvÃ#x9F;3; 8. Thyroid Hormone αvÃ#x9F;3 Receptor and Angiogenesis; 9. Thyroid Hormone αvÃ#x9F;3 Receptor and Tumor Cell Proliferation; 10. Thyroid Hormone αvÃ#x9F;3 Receptor and Regulation of Gene Expression; 11. Thyroid Hormone αvÃ#x9F;3 Receptor and Cell Physiology; 12. Discussion
Series Title: Vitamins and hormones, v. 106.
Responsibility: series editor, Gerald Litwack.

Abstract:

Thyroid hormone, Volume 106, the latest release in the Vitamins and Hormones series first published in 1943 provides up-to-date information on crystal structures and basic structural studies on neurotrophins and their receptors, neurotrophin functions and the biological actions of neurotrophins related to clinical conditions and disease. This new release focuses on timely topics, including the Nuclear Import and Export of the Thyroid Hormone Receptor, the Thyroid hormone and the white matter of the central nervous system: from development to repair, Thyroid hormone and astrocyte differentiation, and the Molecular Basis of Nongenomic Actions of Thyroid Hormone, amongst other topics.

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