Towards Improved Bone Regeneration: Naar verbeterde botregeneratie (Book, 2019) [WorldCat.org]
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Towards Improved Bone Regeneration: Naar verbeterde botregeneratie

Author: Callie Knuth
Publisher: Erasmus University Rotterdam 2019-06-25
Edition/Format: Book Book : English
Summary:
The aim of the thesis, “Towards improved bone regeneration,” was to investigate ways to improve tissue engineered endochondral bone grafts. In this thesis we improve the construction of these grafts by identifying a more stable cell source with more favorable in vitro expansion characteristics compared to current gold standard cells, and expand upon our understanding of how such constructs form bone in vivo by  Read more...
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Details

Document Type: Book
All Authors / Contributors: Callie Knuth
ISBN: 978-94-6361-275-3
Language Note: English
Unique Identifier: 8165625379
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Abstract:

The aim of the thesis, “Towards improved bone regeneration,” was to investigate ways to improve tissue engineered endochondral bone grafts. In this thesis we improve the construction of these grafts by identifying a more stable cell source with more favorable in vitro expansion characteristics compared to current gold standard cells, and expand upon our understanding of how such constructs form bone in vivo by investigating the importance of collagen type X during this process. By creating an easily injectable micropellet construct, an injectable endochondral bone forming construct was developed which could be used in combinational therapies with compounds, such as Emdogain, to perhaps further improve the effectiveness of graft outcomes which are described in more detail below. Together the studies in this thesis move our understanding and possible clinical applications for endochondral bone grafts forward.

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