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Transformative concepts for drug design : target wrapping

Author: Ariel Fernández
Publisher: Berlin ; London : Springer, 2010.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
In spite of the enticing promises of the post-genomic era, the pharmaceutical world is in a state of disarray. Drug discovery seems now riskier and more uncertain than ever. Thus, projects get routinely terminated in mid-stage clinical trials, new targets are getting harder to find, and successful therapeutic agents are often recalled as unanticipated side effects are discovered. Exploiting the huge output of  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Fernández, Ariel, 1957-
Transformative concepts for drug design.
Berlin ; London : Springer, 2010
(OCoLC)502034116
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Ariel Fernández
ISBN: 9783642117923 3642117929 3642117910 9783642117916
OCLC Number: 663096899
Description: 1 online resource (x, 230 pages) : illustrations (some color)
Contents: Protein Cooperativity and Wrapping: Two Themes in the Transformative Platform of Molecular Targeted Therapy --
Wrapping Defects and the Architecture of Soluble Proteins --
Folding Cooperativity and the Wrapping of Intermediate States of Soluble Natural Proteins --
Wrapping Deficiencies and De-wetting Patterns in Soluble Proteins: A Blueprint for Drug Design --
Under-Wrapped Proteins in the Order{u2013}Disorder Twilight: Unraveling the Molecular Etiology of Aberrant Aggregation --
Evolution of Protein Wrapping and Implications for the Drug Designer --
Wrapping as a Selectivity Filter for Molecular Targeted Therapy: Preliminary Evidence --
Re-engineering an Anticancer Drug to Make It Safer: Modifying Imatinib to Curb Its Side Effects --
Wrapping Patterns as Universal Markers for Specificity in the Therapeutic Interference with Signaling Pathways --
Fulfilling a Therapeutic Imperative in Cancer Treatment: Control of Multi-target Drug Impact --
Inducing Folding By Crating the Target --
Wrapper Drugs as Therapeutic Editors of Side Effects --
Wrapper Drugs for Personalized Medicine --
Last Frontier and Back to the Drawing Board: Protein{u2013}Water Interfacial Tension in Drug Design.
Responsibility: by Ariel Fernández.

Abstract:

Profound understanding of how to rationally design drugs.Knowledge of innovative concepts in molecular design with translational and transformative applicability.Development of new therapeutic agents  Read more...

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From a News Release of the Rice University, Houston, Texas:"Drug Design: New book introduces fresh approach. Rice professor says drug industry can improve drug safety, lower costs.The pharmaceutical Read more...

 
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