skip to content
Treatment of bancroftian filariasis with albendazole: evaluation of efficacy and adverse reactions Preview this item
ClosePreview this item
Checking...

Treatment of bancroftian filariasis with albendazole: evaluation of efficacy and adverse reactions

Author: R L Jayakody; C S S De Silva; W M T Weerasinghe
Publisher: 1993.
Edition/Format:   Print book : English
Summary:
ABSTRACT: 27 asymptomatic Wuchereria bancrofti microfilaraemicmale patients were treated with albendazole or DEC, each drug being given daily for three weeks.
Rating:

(not yet rated) 0 with reviews - Be the first.

Subjects
More like this

Find a copy in the library

&AllPage.SpinnerRetrieving; Finding libraries that hold this item...

Details

Document Type: Book
All Authors / Contributors: R L Jayakody; C S S De Silva; W M T Weerasinghe
OCLC Number: 968967367
Notes: Majalah Malaysiana Perubatan.
Responsibility: Jayakody, R.L., De Silva, C.S.S., Weerasinghe, W.M.T.

Abstract:

ABSTRACT: 27 asymptomatic Wuchereria bancrofti microfilaraemicmale patients were treated with albendazole or DEC, each drug being given daily for three weeks.

Altogether 15 patients received albendazole and 12 received DEC. Albendazole was used in dosage of 400 mg twice daily and DEC was used in dosage of 6mg/kg/day. Both drugs showed microfilaricidal effects, this beingless pronounced with albendazole compared to DEC. 15 percent of the albendazole treated and 33 percent of the DEC treated patients were amicrofilaraemic at 6 months follow up.

The geometric means of mf counts, 6 months post-treatment, for albendazole and DEC were 6 and 2 respectively. When these.

Geometric means were expressed as percent of pre-treatment geometric means the values were 1.91 percent and 0.81 percent for albendazole and DEC respectively.

73 percent of albendazole treated patients showed indirect features of killing of adultworms. This manifested as a scrotal syndrome. This feature wasnot seen with DEC. In 2 patients albendazole had to be discontinued because of this adverse effect.

When these patients were followed up for over 15 months some remained microfilariae(mf) negative. Even in those patients who remained mf positive the counts were low. Thus albendazole and DEC in the doses usedin the present study appear to have effects on both mf and adult worms.

No persistent anomalies in biochemical and haematological parameters were seen in either group of patients treated with these drugs.

Reviews

User-contributed reviews
Retrieving GoodReads reviews...
Retrieving DOGObooks reviews...

Tags

Be the first.
Confirm this request

You may have already requested this item. Please select Ok if you would like to proceed with this request anyway.

Linked Data


Primary Entity

<http://www.worldcat.org/oclc/968967367> # Treatment of bancroftian filariasis with albendazole: evaluation of efficacy and adverse reactions
    a schema:CreativeWork, schema:Book ;
    library:oclcnum "968967367" ;
    library:placeOfPublication <http://id.loc.gov/vocabulary/countries/my> ;
    schema:about <http://experiment.worldcat.org/entity/work/data/4033872341#Topic/albendazole_adverse_effects> ; # Albendazole--adverse effects
    schema:about <http://experiment.worldcat.org/entity/work/data/4033872341#Topic/filariasis_drug_therapy> ; # Filariasis--drug therapy
    schema:about <http://experiment.worldcat.org/entity/work/data/4033872341#Topic/wuchereria_bancrofti_drug_effects> ; # Wuchereria bancrofti--drug effects
    schema:bookFormat bgn:PrintBook ;
    schema:contributor <http://experiment.worldcat.org/entity/work/data/4033872341#Person/de_silva_c_s_s> ; # C. S. S. De Silva
    schema:contributor <http://experiment.worldcat.org/entity/work/data/4033872341#Person/weerasinghe_w_m_t> ; # W. M. T. Weerasinghe
    schema:creator <http://experiment.worldcat.org/entity/work/data/4033872341#Person/jayakody_r_l> ; # R. L. Jayakody
    schema:datePublished "1993" ;
    schema:exampleOfWork <http://worldcat.org/entity/work/id/4033872341> ;
    schema:inLanguage "en" ;
    schema:name "Treatment of bancroftian filariasis with albendazole: evaluation of efficacy and adverse reactions"@en ;
    schema:productID "968967367" ;
    schema:publication <http://www.worldcat.org/title/-/oclc/968967367#PublicationEvent/1993> ;
    wdrs:describedby <http://www.worldcat.org/title/-/oclc/968967367> ;
    .


Related Entities

<http://experiment.worldcat.org/entity/work/data/4033872341#Person/de_silva_c_s_s> # C. S. S. De Silva
    a schema:Person ;
    schema:familyName "De Silva" ;
    schema:givenName "C. S. S." ;
    schema:name "C. S. S. De Silva" ;
    .

<http://experiment.worldcat.org/entity/work/data/4033872341#Person/jayakody_r_l> # R. L. Jayakody
    a schema:Person ;
    schema:familyName "Jayakody" ;
    schema:givenName "R. L." ;
    schema:name "R. L. Jayakody" ;
    .

<http://experiment.worldcat.org/entity/work/data/4033872341#Person/weerasinghe_w_m_t> # W. M. T. Weerasinghe
    a schema:Person ;
    schema:familyName "Weerasinghe" ;
    schema:givenName "W. M. T." ;
    schema:name "W. M. T. Weerasinghe" ;
    .

<http://experiment.worldcat.org/entity/work/data/4033872341#Topic/albendazole_adverse_effects> # Albendazole--adverse effects
    a schema:Intangible ;
    schema:name "Albendazole--adverse effects"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/4033872341#Topic/filariasis_drug_therapy> # Filariasis--drug therapy
    a schema:Intangible ;
    schema:name "Filariasis--drug therapy"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/4033872341#Topic/wuchereria_bancrofti_drug_effects> # Wuchereria bancrofti--drug effects
    a schema:Intangible ;
    schema:name "Wuchereria bancrofti--drug effects"@en ;
    .

<http://www.worldcat.org/title/-/oclc/968967367>
    a genont:InformationResource, genont:ContentTypeGenericResource ;
    schema:about <http://www.worldcat.org/oclc/968967367> ; # Treatment of bancroftian filariasis with albendazole: evaluation of efficacy and adverse reactions
    schema:dateModified "2018-12-11" ;
    void:inDataset <http://purl.oclc.org/dataset/WorldCat> ;
    .


Content-negotiable representations

Close Window

Please sign in to WorldCat 

Don't have an account? You can easily create a free account.