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Ubiquitin chains : degradation and beyond

Author: Arnab De
Publisher: Cham : Springer, 2015.
Series: Springer theses.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
This thesis examines the evidence for regulatory ubiquitination by focusing on A20. It provides an insightful and in-depth evaluation of the current literature by critically examining the evidence of K63-linked regulatory ubiquitination in regulating cell-signalling. It is also the first thesis to directly test the role of regulatory ubiquitination in NF-kB signaling in vivo. The case for regulatory ubiquitination  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Printed edition:
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Arnab De
ISBN: 9783319149653 3319149652
OCLC Number: 904755655
Notes: "Doctoral thesis accepted by Columbia University, New York, NY."
Description: 1 online resource (xv, 103 pages) : illustrations (some color).
Contents: 1 Immune homeostasis: Activation and Downregulation of NF-mB --
2 Regulation of NF-mB signaling by regulatory ubiquitination: specific pathways and A20 --
3 The deubiquitinase activity of A20 is dispensable for its role in NF-mB signaling --
4 Perspectives on regulatory ubiquitination.
Series Title: Springer theses.
Responsibility: Arnab De.

Abstract:

This thesis examines the evidence for regulatory ubiquitination by focusing on A20.  Read more...

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