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Understand your DNA : a guide

Author: Lasse Folkersen; Pak Sham
Publisher: Singapore ; Hackensack, NJ : World Scientific Publishing Co. Pte. Ltd., [2019] ©2019
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Are you considering to test your own DNA? Do you want to learn more about your health and ancestry? "Understand your DNA : A Guide" is about what you can use genetics for. For a few hundred dollars, you can now scan your own genes. Millions of people all over the world have already done so. Everyone wants to see what they can get to know about themselves, and the market growing rapidly. But what does it require from  Read more...
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Genre/Form: Electronic books
Popular works
Additional Physical Format: Print version:
Folkersen, Lasse.
Understand your DNA.
Singapore ; Hackensack, NJ : World Scientific Publishing Co. Pte. Ltd., [2019]
(OCoLC)1044552649
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Lasse Folkersen; Pak Sham
ISBN: 9789813273269 9813273267 9789813273276 9813273275
OCLC Number: 1055763239
Description: 1 online resource : illustrations
Contents: Intro; Contents; Foreword; 1. My Daughter's Hair Colour; 2. Basic Introduction to Genetics; 2.1 SNPs, Genomes, and Chromosomes; 2.2 The Alleles that Make the Genotype of a SNP; 2.3 DNA as a Universal Code of Life; 2.4 Different Measurement Methods; 2.5 Rare Genomic Variation; 2.6 Finding Functions of SNPs in Families; 2.7 Finding Functions of Common SNPs in Populations; 2.8 Missing Heritability and Future Methods for Variant Discovery; 3. Methods in Consumer Genetics; 3.1. Case A --
the Basic Level; 3.2. Case B --
Intermediate Level; 3.3. Case C --
Advanced Level 3.4. Data Generation Using Microarrays; 3.5. Data Generation Using DNA Sequencing; 3.6. Imputation: How Can it Help; 3.7. Other Data Generation Methods; 3.8. Interpretation: How can my Genetics Company Know this?; 3.9. Interpretation --
Taking Matters Into Your Own Hands; 4. Ancestry and Genealogy; 4.1. Not Just Where you Come From --
but Also When; 4.2. Calculating Country Percentages; 4.3. Thousand Type Genomes and a Single Mixed One; 4.4. Fine-grained Tools that Won't Dilute with Sex; 4.5. Finding Your Relatives. How and Where?; 5. Rare Disease Genetics --
One SNP at a Time 5.1. Known and Unknown SNPs for Rare Genetic Disease; 5.2. Inheritance Patterns --
Unborn Children and Risk; 5.3. A Panel of FDA Approved Rare Genetic Disease SNPs; 5.4. Interpretations Beyond the FDA Approved SNPs; 5.5. Common Sense and How to Cautiously Interpret Findings; 5.6. Effect Sizes and How a Single SNP Matter to you as an Individual; 5.7. Breast Cancer and the BRCA Mutations; 5.8. Future Benefits of Personal Genetics in Rare Disease; 6. Genetics of Common Traits and Diseases --
Many SNPs Together; 6.1. Discrete Units of Inheritance vs Continuous Traits 6.2. The Genetic Height vs the Actual Height; 6.3. Gene Scores Types and How to Calculate Them; 6.3.1. #1 Effect allele count; 6.3.2. #2 Weighted allele count; 6.3.3. #3 Zero-centred score; 6.3.4. #4 Z-score; 6.4. Typical Confusion in Gene Scores and Common SNP Genetics; 6.5. Utility of Different Gene Scores; 6.6. Precision of a Gene Score --
Not a Single Value, but a Better Guess; 6.7. Genetic Findings you can do Something About --
and Those you Cannot; 6.8. Precision Medicine: Diagnosis vs Treatment Choice; 6.9. Future Benefits of Personal Genetics in Common Complex Disease; 7. The Future 7.1. The Positive Aspects of Genetics; 7.2. The Scary Aspects of Genetics; 7.3. The Truly Problematic Aspects of Genetics; 7.4. The Choice; Acknowledgements and Disclosures; Bibliography; Appendix A Operating Instructions for Impute.me; A.1. Motivation; A.2. The GWAS Module; A.3. The Rare Diseases Module; A.4. BRCA and Mutation Sensor Modules; A.5. The Appearance Module; A.6. The Ethnicity Module; A.7. Health Comparison Module; Index
Responsibility: Lasse Folkersen, Sankt Hans Hospital, Denmark ; foreword by professor Pak Sham.

Abstract:

Are you considering to test your own DNA? Do you want to learn more about your health and ancestry? "Understand your DNA : A Guide" is about what you can use genetics for. For a few hundred dollars, you can now scan your own genes. Millions of people all over the world have already done so. Everyone wants to see what they can get to know about themselves, and the market growing rapidly. But what does it require from you? And what can you really use a DNA test for? "Understand your DNA : A Guide" helps you put the plots and charts of consumer genetics into perspective and enables you to figure out what's up and down in the media headlines. The book is also a key input for today's debate about what we as a society can and want to do with medical genetics. Genetics will play a growing role in the future. "Understand your DNA : A Guide" is an easy-to-read and necessary guide to that future. The book is provided with a foreword by Professor Sham Pak-Chung of Hong Kong University. While there are many books about genetics, they typically take the perspective of a scientist wanting to understand the molecular levels. At the same time, direct-to-consumer genetics is a booming market, with millions of people already tested. Very little has been published that will guide them for real, because the need here is more focused on medical and practical understanding, than focussed on molecules. This book therefore aims to hit that vacant spot in the market. It's a walk-through of all concepts that are necessary to understand in your own analysis. Meanwhile, it is also limited in scope to only those concepts--thus distinguishing it from broader works. The book is appropriate for the readerships in modern multi-ethnic metropolises because it mixes European and Asian examples, both from the collaboration between the author from Europe and the foreword-writer, Prof. Pak Sham of Hong Kong University. But also, because many of the examples in the book concerns differences and similarities between Asian and European ethnicities, something the author believes is a trend in time.

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WorldCat User Reviews (1)

Super useful introduction to genetics in the age of 23andme

by spencerjackson1 (WorldCat user published 2019-02-22) Excellent Permalink

I really enjoyed reading this book. I've read a few on genetics now, but this one is very straightforward and to the point - given that you too have recently bought a consumer genetics kit. It starts with introducing the basics, essentially what you need to know. Then it branches into two main sections:...
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