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Uric acid in chronic kidney disease

Author: Alejandro Treviño-Becerra; Kunitoshi Iseki
Publisher: Basel ; New York : Karger, [2018]
Series: Contributions to nephrology, v. 192.
Edition/Format:   eBook : Document : Primary school : EnglishView all editions and formats
Summary:
Hyperuricemia is often associated with life-style related disorders such as diabetes mellitus, hypertension, and dyslipidemia, which, in turn, are major causes of CKD. Improved management of hyperuricemia is thus expected to be beneficial for both the general population and CKD patients. This book presents new information on uric acid in tubular transport, early recognition of renal lesions, genetic predisposition,  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Treviño-Becerra, A.
Uric Acid in Chronic Kidney Disease.
Basel : S. Karger AG, ©2018
Material Type: Document, Primary school, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Alejandro Treviño-Becerra; Kunitoshi Iseki
ISBN: 9783318062519 3318062510
OCLC Number: 1021808911
Notes: Human Studies on the Role of Uric Acid in Metabolic Syndrome and Diabetes.
Description: 1 online resource.
Contents: Cover; Front Matter; Contents; Foreword; Introduction; Renal Handling of Uric Acid; Abstract; Introduction; Circulating and Urinary Uric Acid Levels; Uric Acid Basis; Tubular Handling and Excretion of Uric Acid; Pathogenic Role of Uric Acid Renal Transport; References; Renal Effects of Hyperuricemia; Abstract; Renal Handling of Uric Acid; Experimental Urate Nephropathy; Acute Uric Acid Nephropathy; Hyperuricemia and Chronic Kidney Disease; Conclusions; References; The Pathophysiology of Uric Acid onRenal Diseases; Abstract; Introduction; A Model for Mild Hyperuricemia. Renal Hemodynamics in HyperuricemiaDamaging Intracellular Pathways Induced by Uric Acid; Conclusions; References; Uric Acid: The Unknown Uremic Toxin; Abstract; Introduction; Physiopathology; Diabetes Mellitus; Clinical Experiences; Conclusion; References; The Association between Serum Uric Acid and Renal Damage: The Takahata Study â#x80;#x93; New Insights; Abstract; Introduction; The Takahata Study; Renal Tubular Damage and Uric Acid; Glomerular Damage and Uric Acid; Uric Acid Threshold Levels for the Development of Renal Damage; The Mechanism by Which Uric Acid Causes Renal Damage. The Link between Uric Acid, Renal Damage, and MortalityConclusion; References; Significance of Hyperuricemia among Community-Based Screening Participants; Abstract; Introduction; Epidemiological Studies; Intervention Study; Conclusion; References; Hyperuricemia and Progression of Chronic Kidney Disease: Role of Phenotype Transition of Renal Tubular and Endothelial Cells; Abstract; Introduction; UA-Induced EMT of Renal Tubular Cells; UA-Induced EndoMT of Endothelial Cells of Peritubular Capillaries; Other Types of Phenotype Transitions in HU; Conclusion; Acknowledgment; Disclosure Statement. ConclusionsReferences; Gout: A Disease of Kings; Abstract; Historical Perspective; Uric Acid Evolution and Primitive Cultures; Epidemiology; Genetics; Conclusions; References; Systemic Implications of Hyperuricemia; Abstract; Introduction; Clinical Approach; Conclusions; References; Uric Acid as a Cause of the Metabolic Syndrome; Abstract; Metabolic Syndrome: A Form of Fat Storage; Role of Fructose in Metabolic Syndrome; Fructose and Uric Acid: Activation of AMP Deaminase; Role of Uric Acid in Fructose-Dependent and -Independent Models of Metabolic Syndrome.
Series Title: Contributions to nephrology, v. 192.
Responsibility: volume editors, Alejandro Treviño-Becerra, Kunitoshi Iseki.

Abstract:

Hyperuricemia is often associated with life-style related disorders such as diabetes mellitus, hypertension, and dyslipidemia, which, in turn, are major causes of CKD. Improved management of hyperuricemia is thus expected to be beneficial for both the general population and CKD patients. This book presents new information on uric acid in tubular transport, early recognition of renal lesions, genetic predisposition, preeclampsia, metabolic syndrome, diabetes, high blood pressure in the young, and the relationship with vitamin D. Moreover, the relationship between AKI and uric acid, as well as the rejection of renal transplants due to hyperuricemia, are discussed. This publication will be of interest to both general practitioners and researchers working in the field of CKD. It provides new insights into renal damage caused by hyperuricemia and into prevention and treatment possibilities.

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