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Viral pathogenesis : from basics to systems biology

Author: Michael G Katze; Marcus J Korth; G Lynn Law; Neal Nathanson
Publisher: Amsterdam : Academic Press, 2016.
Edition/Format:   eBook : Document : English : Third editionView all editions and formats
Summary:
Viral Pathogenesis: From Basics to Systems Biology, Third Edition, has been thoroughly updated to cover topical advances in the evolving field of viral pathogenesis, while also providing the requisite classic foundational information for which it is recognized. The book provides key coverage of the newfound ability to profile molecular events on a system-wide scale, which has led to a deeper understanding of  Read more...
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Additional Physical Format: Print version :
Material Type: Document
Document Type: Book, Computer File
All Authors / Contributors: Michael G Katze; Marcus J Korth; G Lynn Law; Neal Nathanson
ISBN: 9780128011744 0128011742
OCLC Number: 1006507406
Description: 1 online resource
Contents: Front Cover; Viral Pathogenesis From Basics to Systems Biology; Copyright; Contents; Contributors; Preface; The Future Is Now!; I --
History and Essentials of Viral Pathogenesis; 1 --
The Human Toll of Viral Diseases: Past Plagues and Pending Pandemics; 1. INTRODUCTION; 2. THE HUMAN TOLL OF SPECIFIC VIRAL DISEASES; 2.1 Smallpox; 2.2 HIV/AIDS; 2.3 Influenza; 2.4 Measles; 2.5 The Global Toll of Viral Infections; 3. EPIDEMICS AND SOCIETY; 3.1 Epidemic Yellow Fever in Philadelphia, 1793; 3.2 Eradication of Wild Polioviruses; 4. VIRUSES, PRIONS, AND CHRONIC DISEASE; 4.1 Prion Diseases 5. LESSONS LEARNED: THE ROOT CAUSES OF SIGNIFICANT VIRAL DISEASES OF HUMANS6. VIRAL INFECTIONS OF ANIMALS; 6.1 SARS; 6.2 Rinderpest; 7. SCORE CARD: ARE WE CONTROLLING MAJOR VIRAL DISEASES?; 8. PANDEMICS YET TO COME: WHAT DOES THE FUTURE HOLD?; 8.1 Modern Diagnostics and Global Surveillance; 8.2 Influenza: Will It Cause the Next Human Pandemic?; 8.3 Ebola Pandemic; 9. FINAL COMMENTS; FURTHER READING; Smallpox; HIV/AIDS; Influenza; SARS; Measles; Rinderpest; Poliomyelitis; Yellow Fever; Prions; 2 --
Historical Roots: The Family Tree of Viral Pathogenesis; 1. FROM CELLS AND VIRUSES TO DISEASES 1.1 Pathogenesis in the Modern Sense1.2 The Concept of "Virus"; 1.3 Virus Pathogenesis in Jenner's Time; 1.4 Fermentation, Putrefaction, and Putrid Intoxication; 2. THE CELLULAR PATHOLOGY OF VIRCHOW; 3. PASTEUR AND MICROBES; 3.1 Filterable Agents and Their Nature; 4. CYTOPATHOLOGY: RETURN TO PATHOGENESIS; 5. HOST RESPONSES AS PATHOLOGIES; 5.1 The Twenty-First Century; 6. REPRISE; FURTHER READING; 3 --
Basic Concepts: A Step-by-Step Guide to Viral Infection; 1. VIRUS-CELL INTERACTIONS; 1.1 Cellular Receptors and Viral Tropism; 1.2 Viral Entry 1.3 Virus Structure and Replication Can Impact Pathogenesis2. ROUTES OF VIRAL TRANSMISSION; 3. VIRAL DISSEMINATION AND MOVEMENT; 3.1 Movement on the Microscope Scale; 3.2 Long-Range Movement within the Host; 4. VIRUS SHEDDING AND TRANSMISSION; 5. PATTERNS OF VIRUS INFECTION; 6. MAJOR DISEASE MECHANISMS; 7. REPRISE; FURTHER READING; 4 --
Innate Immunity: Recognizing and Responding to Foreign Invaders-No Training Needed; 1. INTRODUCTION; 2. INTERFERONS; 2.1 Types of IFN; 2.2 IFN Signaling; 2.3 Cell Intrinsic Antiviral Defense; 2.4 Evading Type 1 IFN Antiviral Effects 2.5 IFNs and Immune Regulation3. SENSORS OF INFECTION; 3.1 The Toll-like Receptors; 3.2 Cytosolic Receptors; 4. INNATE IMMUNE CELLS; 4.1 Monocytes/Macrophages; 4.2 Dendritic Cells; 4.3 NK Cells; 4.3.1 NK Cell Functions; 4.3.2 Responses to Innate Cytokines; 4.3.3 NK Cell Activating Receptors; 4.3.4 NK Cell Inhibitory Receptors; 5. DEFENSINS; 6. COMPLEMENT AND "NATURAL" ANTIBODIES; 7. RELATIONSHIP BETWEEN INNATE AND ADAPTIVE IMMUNE RESPONSES; 8. INNATE FUNCTIONS IN SUSTAINED OR SUBSEQUENT VIRAL INFECTION; 9. INDIVIDUAL VARIATION; 10. REPRISE; FURTHER READING 5 --
Adaptive Immunity: Neutralizing, Eliminating, and Remembering for the Next Time
Responsibility: edited by Michael G. Katze, Marcus J. Korth, G. Lynn Law, Neal Nathanson.

Abstract:

Viral Pathogenesis: From Basics to Systems Biology, Third Edition, has been thoroughly updated to cover topical advances in the evolving field of viral pathogenesis, while also providing the requisite classic foundational information for which it is recognized. The book provides key coverage of the newfound ability to profile molecular events on a system-wide scale, which has led to a deeper understanding of virus-host interactions, host signaling and molecular-interaction networks, and the role of host genetics in determining disease outcome. In addition, the content has been augmented with short chapters on seminal breakthroughs and profiles of their progenitors, as well as short commentaries on important or controversial issues in the field. Thus, the reader will be given a view of virology research with perspectives on issues such as biomedical ethics, public health policy, and human health. In summary, the third edition will give the student a sense of the exciting new perspectives on viral pathogenesis that have been provided by recent developments in genomics, computation, modeling, and systems biology.

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