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Vitamin C Volume I

Author: C Alan B Clemetson
Publisher: Milton : CRC Press, 2018.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
The factors affecting blood vitamin C levels are described in detail in this series. Many factors such as aging, smoking, infection, trauma, surgery, hemolysis, hormone administration, heavy metals, pregnancy, alcohol, ionizing radiation and several medicines have been found to cause a disturbance of ascorbic acid metabolism and to reduce blood vitamin C levels. Indeed, abnormalities of ascorbic acid metabolism, due  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Clemetson, Alan B.
Vitamin C : Volume I.
Milton : CRC Press, ©2018
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: C Alan B Clemetson
ISBN: 9781351094467 1351094467 9781351077569 1351077562 9781351086011 1351086014
OCLC Number: 1020031341
Description: 1 online resource (337 pages)
Contents: Cover; Title Page; Copyright Page; FOREWORD; PREFACE; THE AUTHOR; Table of Contents; VITAMIN C DEFICIENCY; Chapter 1: Classical Scurvy: A Historical Review; Chapter 2: Chronic Subclinical Ascorbic Acid Deficiency; FACTORS AFFECTING THE ECONOMY OF ASCORBIC ACID; Chapter 3: Inadequate Ascorbic Acid Intake; References; Chapter 4: Smoking; References; Chapter 5: Aging; I. Human Studies; II. Animal Studies; A. Guinea Pigs; B. Cockerels; C. Rats; III. Clinical Associations, Clinical Trials; IV. Oxidant Theory; V. Future Research; References; Chapter 6: Sex; I. Guinea Pigs; II. Rats; III. Humans II. In Vitro â#x80;#x94; EnzymaticIII. In Vivo â#x80;#x94; Animal; IV. In Vivo â#x80;#x94; Human; V. Historical Note; References; Chapter 11: Bioflavonoids; References; Chapter 12: Dietary Protein; I. Quantity of Protein; II. Quality of Protein; III. Relative Deficiency of Protein; References; Chapter 13: Hormone Administration: Birth Control Pills; I. Introduction; II. Adrenocorticotropic Hormone (ACTH); III. Gonadotropins; IV. Growth Hormone; V. Cortisone; VI. Thyroxin, Thyrotrophic Hormone; VII. Adrenaline (Epinephrine); VIII. Insulin; IX. Estrogens: Birth Control Pills; X. Androgens; References Chapter 14: PregnancyI. Plasma and Leukocyte Ascorbic Acid Levels in Pregnancy; II. Blood Histamine Levels; III. The Question of Ascorbic Acid Synthesis; IV. Placental Histaminase Activity; V. The Placental Transfer of Ascorbic Acid; VI. Ascorbic Acid Metabolism in Pregnancy; VII. Capillary Fragility and the Pregnancy Cycle; VIII. Labor; IX. Puerperium; X. The Newborn; XI. Congenital Abnormalities; XII. Vitamin C Toxicity?; XIII. Conclusions; References; Chapter 15: Hemolysis; References; Chapter 16: Stress and the Pituitary-Adrenal System; I. Stress II. ACTH and Adrenal Ascorbic Acid DepletionIII. The Effects of ACTH and Cortisone on Ascorbic Acid Metabolism; References; Chapter 17: Lack of Sleep; I. Introduction; II. Origin of Study; III. Blood Histamine and Ascorbic Acid Levels of Resident Physicians After Night Duty; A. Whole Blood Histamine Analysis; B. Plasma Reduced Ascorbic Acid Analysis; C. Results; IV. Discussion; Acknowledgment; References; Chapter 18: Time of Day; I. Related Circadian Rhythms; A. Circadian Rhythms of Adrenal Ascorbic Acid Content and Adrenal Cortical Function B. Circadian Rhythms of Plasma Ascorbic Acid and Plasma Cortisol
Responsibility: author, C. Alan B. Clemetson.

Abstract:

The factors affecting blood vitamin C levels are described in detail in this series. Many factors such as aging, smoking, infection, trauma, surgery, hemolysis, hormone administration, heavy metals, pregnancy, alcohol, ionizing radiation and several medicines have been found to cause a disturbance of ascorbic acid metabolism and to reduce blood vitamin C levels. Indeed, abnormalities of ascorbic acid metabolism, due to factors such as smoking, occur much more frequently than does dietary vitamin C deficiency today. It is now known that low blood vitamin C levels are associated with histaminemia (high blood histamine levels), and also that ascorbate-responsive histaminemia is common in apparently healthy people. High blood histamine levels are believed to cause small hemorrhages within the inner walls of the blood vessels and these may lead to the deposition of cholesterol, as an aberrant form of wound healing. Ascorbic acid not only reduces blood histamine levels, but also aids the conversion of cholesterol to bile acids in the liver. The clinical pathological and chemical changes observed in ascorbic acid deficiency are discussed in detail. Several diseases and disorders associated with low blood vitamin C levels are also described. Possible toxic effects resulting from the oxidation of ascorbic acid are noted, and reasons for the use of D-catechin or other chelating fiber to prevent or minimize the release of ascorbate-free radical are detailed. An excellent reference for physicians, nutritionists and other scientists.

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