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Wnt signaling in embryonic development

Author: Sergei Y Sokol
Publisher: Amsterdam ; Boston : Elsevier, 2007.
Series: Advances in developmental biology (Amsterdam, Netherlands), v. 17.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
A superb compilation of reviews from leading experts in the field of Wnt signaling, volume 17 in the Advances in Developmental Biology series offers 7 chapters, each devoted to a separate area of research on Wnt signaling. Written by specialists in the field, these chapters cover different levels of signaling, including: ligands, receptors, cytoplasmic and nuclear components of the pathway. This book discusses a  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Wnt signaling in embryonic development.
Amsterdam ; Boston : Elsevier, 2007
(OCoLC)84915852
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Sergei Y Sokol
ISBN: 9780080471341 008047134X 0444528741 9780444528742
OCLC Number: 123357071
Description: 1 online resource (xiii, 248 pages) : illustrations (some color).
Contents: Cover --
Front Cover --
Wnt Signaling in Embryonic Development --
Copyright Page --
Contents --
List of Contributors --
Preface --
Common principles and species differences --
Processes involved --
Pathway or network: Variations of different steps in signal transduction --
Looking ahead --
Chapter 1: Wnt/beta-catenin-mediated transcriptional regulation --
1. Introduction --
2. The TCF family as mediators of Wnt/beta-catenin signaling --
3. The "Off state": Repression of Wnt targets in the absence of signaling --
4. The "On State" in the nucleus; Arm/beta-catenin triggers the switch --
5. beta-Catenin-mediated gene repression --
6. Switching off signaling: A nuclear role for the destruction complex --
7. Concluding remarks --
References --
Chapter 2: Wnt signaling and the establishment of cell polarity --
1. Wnt-signaling pathways --
2. Apical-basal and Planar Cell Polarity --
3. Regulation of apical-basal polarity by Wnt signaling --
4. PCP signaling in the Drosophila wing --
5. PCP signaling in the Drosophila eye --
6. PCP signaling is conserved in mammalian epithelium --
7. Noncanonical Wnt signaling and polarized cell movements --
8. Wnt signaling and asymmetric cell division --
9. A new model system for PCP --
10. Future directions --
References --
Chapter 3: Wnt signaling in C. elegans: New insights into the regulation of POP-1/TCF-mediated activation and repression --
1. Introduction --
2. Wnt signaling in C. elegans: Pathway components --
3. A canonical Wnt pathway regulates Hox gene expression --
4. Wnt/MAPK signaling --
5. P2/EMS signaling: Spindle orientation and endoderm induction --
6. T cell polarity --
7. Z1/4 polarity: Axis determination in the somatic gonad --
8. Multiple mechanisms regulate POP-1 transcriptional activity --
References --
Chapter 4: The Wnt-signaling pathways in mammalian patterning and morphogenesis --
1. Introduction --
2. The canonical Wnt pathway in mammalian patterning --
3. The noncanonical Wnt pathway in mammalian morphogenesis --
4. Summary --
References --
Chapter 5: Cell migration under control of Wnt-signaling in the vertebrate embryo --
1. Introduction --
2. Modes of cell migration in the vertebrate embryo --
3. Cell migration in the early embryo --
4. Neuronal migration --
5. Cell migration in eye development --
6. Heart development --
7. Conclusions --
Acknowledgments --
References --
Chapter 6: Multiple roles for Wnt signaling in the development of the vertebrate neural crest --
1. Introduction --
2. Wnt signals and neural crest induction --
3. Expression of Wnt ligands and receptors --
4. Gain- and loss-of-function studies --
5. Wnt signals and a hierarchy of regulatory steps --
6. Wnt signals in delamination and the onset of migration --
7. Wnt signals and neural crest cell fate diversification --
8. Conclusions and future directions --
Acknowledgments --
References --
Chapter 7: Wnt pathways in angiogenesis --
1. Angiogenesis: A brief introduction --
2. Wnts and Frizzleds in vascular biology --
3. Wnt signaling and pathological angiogenesis.
Series Title: Advances in developmental biology (Amsterdam, Netherlands), v. 17.
Responsibility: editor, Sergei Y. Sokol.

Abstract:

Presents reviews from leading experts in the field of Wnt signaling. Part of the "Advances in Developmental Biology" series, this book covers different levels of signaling, including: ligands,  Read more...

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