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Saha, Abhijit

Overview
Works: 9 works in 23 publications in 1 language and 191 library holdings
Genres: Charts, diagrams, etc  Academic theses 
Roles: Author, Editor
Publication Timeline
Key
Publications about Abhijit Saha
Publications by Abhijit Saha
Most widely held works by Abhijit Saha
Molecular recognition of DNA double helix : gene regulation and photochemistry of BrU substituted DNA ; development of chemical biology tools by Abhijit Saha( file )
2 editions published in 2018 in English and held by 116 libraries worldwide
In this book, the molecular recognition of DNA using small molecules is discussed, with a study of the photochemistry of BrU-labeled DNA. The purposes of the study were to develop small molecules for regenerative medicine, to develop a method to detect the recognition site of small molecules, and to detect the most important biological phenomena using the photochemistry of BrU-labeled DNA. The study began with the design and development of small molecules that can induce pluripotency genes. To deal with the important issue of cell permeability of the original compound, a new analogue of the original with improved gene expression was designed and synthesized. Using the photochemistry of BrU-labeled DNA, crucial biological phenomena such as cooperativity between transcription factors were detected. For the first time, the cooperativity was examined by excess electron transfer assay. DNA was also studied very carefully in order to understand the mechanism of the double-strand break in the UVA micro-irradiation technique. The mechanism of the double strand remained untouched. Nevertheless, the double-strand break mechanism was clearly demonstrated by Hoechst dye, as shown in this book.
Hubble Space Telescope : the GO and GTO observing programs by Space Telescope Science Institute (U.S.)( Book )
5 editions published between 1990 and 1991 in English and held by 38 libraries worldwide
Molecular Recognition of DNA Double Helix : Gene Regulation and Photochemistry of BrU Substituted DNA by Abhijit Saha( file )
6 editions published in 2018 in English and Undetermined and held by 27 libraries worldwide
In this book, the molecular recognition of DNA using small molecules is discussed, with a study of the photochemistry of BrU-labeled DNA. The purposes of the study were to develop small molecules for regenerative medicine, to develop a method to detect the recognition site of small molecules, and to detect the most important biological phenomena using the photochemistry of BrU-labeled DNA. The study began with the design and development of small molecules that can induce pluripotency genes. To deal with the important issue of cell permeability of the original compound, a new analogue of the original with improved gene expression was designed and synthesized. Using the photochemistry of BrU-labeled DNA, crucial biological phenomena such as cooperativity between transcription factors were detected. For the first time, the cooperativity was examined by excess electron transfer assay. DNA was also studied very carefully in order to understand the mechanism of the double-strand break in the UVA micro-irradiation technique. The mechanism of the double strand remained untouched. Nevertheless, the double-strand break mechanism was clearly demonstrated by Hoechst dye, as shown in this book
A survey of halo RR Lyrae stars by Abhijit Saha( Archival Material )
5 editions published between 1984 and 1986 in English and held by 5 libraries worldwide
A survey of halo RR Lyrae stars by Abhijit Saha( Book )
1 edition published in 1984 in Undetermined and held by 1 library worldwide
NOTE: Text or symbols not renderable in plain ASCII are indicated by [...]. Abstract is included in .pdf document. A survey of RR Lyrae stars has been conducted in selected regions of the Galactic halo, using the 48 inch Schmidt telescope at Palomar. 29 RR Lyrae stars were found in three fields (each is 42 square degrees) centered at 1 = 180°, b = 24°; 1 = 180°, b = 30°and 1 = 110°, b = -30°. The faint limit for finding RR Lyraes is 19[...].5 in B, and the faintest RR Lyrae stars that were found are at Galactocentric distances of over 40 kpc. The majority of the stars are 20 to 30 kpc from the Galactic center, and typically around 18[...] in B. Apart from a very few globular clusters, these stars are the most distant known probes of the outer halo. Photoelectric photometry done with the 60 inch telescope at Palomar has been used to obtain accurate light curves and ephemerides for all the survey RR Lyraes stars. Spectrophotometry at minimum light has been used to estimate reddening and interstellar extinction. Distances to the individual RR Lyrae stars have been derived using the information thus obtained. The space densities of RR Lyrae stars has been traced out to a Galactocentric distance R of 33 kpc. The data are combined with that obtained by others in the Galactic bulge and in the relatively nearby halo, which gives an overall picture of the run of space densities over a very wide range of R. Spectra of many of these objects have been taken with the double spectrograph on the 200 inch telescope at Palomar. Chemical abundances and radial velocities have been derived from them. Center of mass velocities have typically been obtained to an accuracy of 35 km s[...]. There is no discernible abundance gradient in the halo from 10 to 40 kpc, but there is a very wide range of abundances. Two RR Lyrae stars have been found which have metallicities that are unprecedentedly high ([Fe/H] ~ -0.5]) for this region of the halo. If the results are confirmed, this will imply tha
The G-Quadruplex-Specific RNA Helicase DHX36 Regulates p53 Pre-mRNA 3′-End Processing Following UV-Induced DNA Damage ( file )
1 edition published in 2017 in English and held by 1 library worldwide
Abstract: Pre-mRNA 3′-end processing, the process through which almost all eukaryotic mRNAs acquire a poly(A) tail is generally inhibited during the cellular DNA damage response leading to a profound impact on the level of protein expression since unprocessed transcripts at the 3′-end will be degraded or unable to be transported to the cytoplasm. However, a compensatory mechanism involving the binding of the hnRNP H/F family of RNA binding proteins to an RNA G-quadruplex (G4) structure located in the vicinity of a polyadenylation site has previously been described to allow the transcript encoding the p53 tumour suppressor protein to be properly processed during DNA damage and to provide the cells with a way to react to DNA damage. Here we report that the DEAH (Asp-Glu-Ala-His) box RNA helicase DHX36/RHAU/G4R1, which specifically binds to and resolves parallel-stranded G4, is necessary to maintain p53 pre-mRNA 3′-end processing following UV-induced DNA damage. DHX36 binds to the p53 RNA G4, while mutation of the G4 impairs the ability of DHX36 to maintain pre-mRNA 3′-end processing. Stabilization of the p53 RNA G4 with two different G4 ligands ( PNA DOTASQ and PhenDC3), which is expected from previous studies to prevent DHX36 from binding and unwinding G4s, also impairs p53 pre-mRNA 3′-end processing following UV. Our work identifies DHX36 as a new actor in the compensatory mechanisms that are in place to ensure that the mRNAs encoding p53 are still processed following UV. Graphical Abstract: Highlights: DHX36 (RHAU/G4R1) is necessary to maintain p53 pre-mRNA 3′-end processing (polyadenylation) following UV. Impaired p53 pre-mRNA 3′-end processing following depletion of DHX36 results in a loss of p53 protein in response to UV-induced DNA damage. DHX36 binds to the p53 RNA G4-forming sequence. Stabilization of the p53 RNA G4 impairs pre-mRNA 3′-end processing following UV
A Survey of Halo RR Lyrae Stars by Abhijit Saha( Archival Material )
1 edition published in 1984 in Undetermined and held by 1 library worldwide
<p>A survey of RR Lyrae stars has been conducted in selected regions of the Galactic halo, using the 48 inch Schmidt telescope at Palomar. 29 RR Lyrae stars were found in three fields (each is 42 square degrees) centered at 1 = 180°, b = 24°; 1 = 180°, b = 30° and 1 = 110°, b = -30°. The faint limit for finding RR Lyraes is 19<sup>m</sup>.5 in B, and the faintest RR Lyrae stars that were found are at Galactocentric distances of over 40 kpc. The majority of the stars are 20 to 30 kpc from the Galactic center, and typically around 18<sup>m</sup> in B. Apart from a very few globular clusters, these stars are the most distant known probes of the outer halo.</p> <p>Photoelectric photometry done with the 60 inch telescope at Palomar has been used to obtain accurate light curves and ephemerides for all the survey RR Lyraes stars. Spectrophotometry at minimum light has been used to estimate reddening and interstellar extinction. Distances to the individual RR Lyrae stars have been derived using the information thus obtained.</p> <p>The space densities of RR Lyrae stars has been traced out to a Galactocentric distance R of 33 kpc. The data are combined with that obtained by others in the Galactic bulge and in the relatively nearby halo, which gives an overall picture of the run of space densities over a very wide range of R.</p> <p>Spectra of many of these objects have been taken with the double spectrograph on the 200 inch telescope at Palomar. Chemical abundances and radial velocities have been derived from them. Center of mass velocities have typically been obtained to an accuracy of 35 km s<sup>-1</sup>.</p> <p>There is no discernible abundance gradient in the halo from 10 to 40 kpc, but there is a very wide range of abundances. Two RR Lyrae stars have been found which have metallicities that are unprecedentedly high ([Fe/H] ~ -0.5]) for this region of the halo. If the results are confirmed, this will imply that there is a sizeable population of moderately metal rich sta
Effect of zero tillage on the growth and yield of winter oilseed crops by Abhijit Saha( Archival Material )
1 edition published in 1987 in English and held by 1 library worldwide
The GO and GTO observing programs ( Book )
1 edition published in 1991 in English and held by 1 library worldwide
 
Languages
English (20)
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